Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Ole, Kiehn"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Where and how the command signal for initiation of locomotion is integrated in the spinal cord has remained unresolved. Here, the authors uncover the functional chain of this signal from the brainstem locomotor command areas to neurons in the spinal
Externí odkaz:
https://doaj.org/article/c8071c76a0a54c2d9dbff5518fd81773
Autor:
Débora Masini, Ole Kiehn
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-23 (2022)
Here, the authors use cell-type specific stimulation of brainstem neurons within the caudal pedunculopontine nucleus to show that activation of excitatory neurons can normalize severe locomotor deficit in mouse models of parkinsonism. The study defin
Externí odkaz:
https://doaj.org/article/30f2c05d6d094afa81d8ac2f1827ce5b
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Here the authors show in a model of ALS that motor neurons receive stronger inhibitory synaptic inputs than slow motor neurons, and disease progression is associated with specific loss of inhibitory synapses onto fast motor neurons.
Externí odkaz:
https://doaj.org/article/2d524ec808c645ff969f21c21afd1cea
Autor:
Haohao Wu, Charles Petitpré, Paula Fontanet, Anil Sharma, Carmelo Bellardita, Rolen M. Quadros, Paulo R. Jannig, Yiqiao Wang, J. Alexander Heimel, Kylie K. Y. Cheung, Simone Wanderoy, Yang Xuan, Konstantinos Meletis, Jorge Ruas, Channabasavaiah B. Gurumurthy, Ole Kiehn, Saida Hadjab, François Lallemend
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Molecular diversity of proprioceptive neuron types (Ia, Ib and II PNs) is unclear. Here, the authors characterized the functional organization and development of eight subtypes of PNs in mice. Importantly, Ia subtypes are plastic, suggesting a role i
Externí odkaz:
https://doaj.org/article/bf14515821cc4d14bb384469db2ce5f5
Autor:
Ilary Allodi, Jik Nijssen, Julio Aguila Benitez, Christoph Schweingruber, Andrea Fuchs, Gillian Bonvicini, Ming Cao, Ole Kiehn, Eva Hedlund
Publikováno v:
Stem Cell Reports, Vol 12, Iss 6, Pp 1329-1341 (2019)
Summary: Oculomotor neurons, which regulate eye movement, are resilient to degeneration in the lethal motor neuron disease amyotrophic lateral sclerosis (ALS). It would be highly advantageous if motor neuron resilience could be modeled in vitro. Towa
Externí odkaz:
https://doaj.org/article/8aab84b2e94146b09c85298df39a7ab2
Autor:
Carmelo Bellardita, Navneet A. Vasistha, Susmita Malwade, Konstantin Khodosevich, Matej Andelic, Borna Moric, Irina Korshunova, Janina Gasthaus, Ole Kiehn
Publikováno v:
Malwade, S, Gasthaus, J, Bellardita, C, Andelic, M, Moric, B, Korshunova, I, Kiehn, O, Vasistha, N A & Khodosevich, K 2022, ' Identification of Vulnerable Interneuron Subtypes in 15q13.3 Microdeletion Syndrome Using Single-Cell Transcriptomics ', Biological Psychiatry, vol. 91, no. 8, pp. 727-739 . https://doi.org/10.1016/j.biopsych.2021.09.012
BACKGROUND: A number of rare copy number variants (CNVs) have been linked to neurodevelopmental disorders. However, because CNVs encompass many genes, it is often difficult to identify the mechanisms that lead to developmental perturbations.METHODS:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30ce498f8e211cbffd65fac9781faae
https://doi.org/10.1016/j.biopsych.2021.09.012
https://doi.org/10.1016/j.biopsych.2021.09.012
Publikováno v:
Hsu, L J, Bertho, M & Kiehn, O 2023, ' Deconstructing the modular organization and real-time dynamics of mammalian spinal locomotor networks ', Nature Communications, vol. 14, no. 1, 873 . https://doi.org/10.1038/s41467-023-36587-w
Locomotion empowers animals to move. Locomotor-initiating signals from the brain are funneled through descending neurons in the brainstem that act directly on spinal locomotor circuits. Little is known in mammals about which spinal circuits are targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f6ee35890b51655e1d4355c036dc19
https://doi.org/10.1038/s41467-023-36587-w
https://doi.org/10.1038/s41467-023-36587-w
Publikováno v:
Bio-Protocol, Vol 8, Iss 7 (2018)
Spinal cord injury (SCI) is characterized by multiple sensory/motor impairments that arise from different underlying neural mechanisms. Linking specific sensory/motor impairments to neural mechanism is limited by a lack of direct experimental access
Externí odkaz:
https://doaj.org/article/e8573f05ab9e4033b4fdfb1b61c63666
Autor:
Carmelo Bellardita, Vittorio Caggiano, Roberto Leiras, Vanessa Caldeira, Andrea Fuchs, Julien Bouvier, Peter Löw, Ole Kiehn
Publikováno v:
eLife, Vol 6 (2017)
Spasms after spinal cord injury (SCI) are debilitating involuntary muscle contractions that have been associated with increased motor neuron excitability and decreased inhibition. However, whether spasms involve activation of premotor spinal excitato
Externí odkaz:
https://doaj.org/article/190935b88390497ba93561e4b76177e1
Autor:
Vladimir F. Lyalka, Ole Kiehn, Pavel V. Zelenin, Adolfo E. Talpalar, Manideep G. Vemula, Tatiana G. Deliagina
Publikováno v:
Zelenin, P V, Vemula, M G, Lyalka, V F, Kiehn, O, Talpalar, A E & Deliagina, T G 2021, ' Differential contribution of V0 interneurons to execution of rhythmic and non-rhythmic motor behaviors ', The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 41, no. 15, pp. 3432-3445 . https://doi.org/10.1523/JNEUROSCI.1979-20.2021
J Neurosci
J Neurosci
Locomotion, scratching, and stabilization of the body orientation in space are basic motor functions which are critically important for animal survival. Their execution requires coordinated activity of muscles located in the left and right halves of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c069908104acac53893676f39d7bbef0
https://doi.org/10.1523/jneurosci.1979-20.2021
https://doi.org/10.1523/jneurosci.1979-20.2021