The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis.

Autor: Englebert K; ULB Center for Research in Immunology (U-CRI), Université Libre de Bruxelles (ULB), Brussels, Belgium; Immunobiology Lab, ULB, Gosselies, Belgium., Taquin A; ULB Center for Research in Immunology (U-CRI), Université Libre de Bruxelles (ULB), Brussels, Belgium; Immunobiology Lab, ULB, Gosselies, Belgium., Azouz A; ULB Center for Research in Immunology (U-CRI), Université Libre de Bruxelles (ULB), Brussels, Belgium; Institute for Medical Immunology (IMI), ULB, Gosselies, Belgium., Acolty V; ULB Center for Research in Immunology (U-CRI), Université Libre de Bruxelles (ULB), Brussels, Belgium; Immunobiology Lab, ULB, Gosselies, Belgium., Vande Velde S; Interuniversity Institute of Bioinformatics in Brussels (ULB-VUB), Brussels, Belgium; Machine Learning Group, ULB, Brussels, Belgium., Vanhollebeke M; ULB Center for Research in Immunology (U-CRI), Université Libre de Bruxelles (ULB), Brussels, Belgium; Immunobiology Lab, ULB, Gosselies, Belgium., Innes H; ULB Center for Research in Immunology (U-CRI), Université Libre de Bruxelles (ULB), Brussels, Belgium; Immunobiology Lab, ULB, Gosselies, Belgium., Boon L; JJP Biologics, Warsaw, Poland., Keler T; Celldex Therapeutics, Hampton, NJ, USA., Leo O; ULB Center for Research in Immunology (U-CRI), Université Libre de Bruxelles (ULB), Brussels, Belgium; Immunobiology Lab, ULB, Gosselies, Belgium., Goriely S; ULB Center for Research in Immunology (U-CRI), Université Libre de Bruxelles (ULB), Brussels, Belgium; Immunobiology Lab, ULB, Gosselies, Belgium; Institute for Medical Immunology (IMI), ULB, Gosselies, Belgium., Moser M; ULB Center for Research in Immunology (U-CRI), Université Libre de Bruxelles (ULB), Brussels, Belgium; Immunobiology Lab, ULB, Gosselies, Belgium., Oldenhove G; ULB Center for Research in Immunology (U-CRI), Université Libre de Bruxelles (ULB), Brussels, Belgium; Immunobiology Lab, ULB, Gosselies, Belgium. Electronic address: guillaume.oldenhove@ulb.be.

Publikováno v: Cell reports [Cell Rep] 2024 Mar 26; Vol. 43 (3), pp. 113824. Date of Electronic Publication: 2024 Feb 21.

A Metabolic Gene Survey Pinpoints Fucosylation as a Key Pathway Underlying the Suppressive Function of Regulatory T Cells in Cancer.

Autor: Pinioti S; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Flanders Institute for Biotechnology (VIB), Leuven, Belgium.; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium., Sharma H; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Flanders Institute for Biotechnology (VIB), Leuven, Belgium.; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium., Flerin NC; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Flanders Institute for Biotechnology (VIB), Leuven, Belgium.; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium., Yu Q; Laboratory for Functional Epigenetics, Department of Human Genetics, KU Leuven, Leuven, Belgium., Tzoumpa A; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Flanders Institute for Biotechnology (VIB), Leuven, Belgium.; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium., Trusso Cafarello S; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Flanders Institute for Biotechnology (VIB), Leuven, Belgium.; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium., De Bousser E; Medical Biotechnology Center, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium., Callewaert N; Medical Biotechnology Center, VIB, Ghent, Belgium.; Department of Biochemistry and Microbiology, Ghent University, Ghent, Belgium., Oldenhove G; Laboratory of Immunobiology, Université Libre de Bruxelles, Gosselies, Belgium.; U-CRI (UCL Center for Research in Immunology), Université Libre de Bruxelles, Gosselies, Belgium., Schlenner S; Department of Microbiology, Immunology and Transplanation, KU Leuven, Leuven, Belgium., Thienpont B; Laboratory for Functional Epigenetics, Department of Human Genetics, KU Leuven, Leuven, Belgium., Garg AD; Laboratory for Cell Stress & Immunity (CSI), Department for Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium., Di Matteo M; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Flanders Institute for Biotechnology (VIB), Leuven, Belgium.; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium., Mazzone M; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Flanders Institute for Biotechnology (VIB), Leuven, Belgium.; Laboratory of Tumor Inflammation and Angiogenesis, Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven, Belgium.

Publikováno v: Cancer immunology research [Cancer Immunol Res] 2023 Dec 01; Vol. 11 (12), pp. 1611-1629.

Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs.

Autor: Bowakim-Anta N; Laboratory of Immunobiology, Université Libre de Bruxelles (ULB), Gosselies, Belgium., Acolty V; Laboratory of Immunobiology, Université Libre de Bruxelles (ULB), Gosselies, Belgium., Azouz A; Institute for Medical Immunology, Center for Research in Immunology (U-CRI), Université Libre de Bruxelles (ULB), Gosselies, Belgium., Yagita H; Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan., Leo O; Laboratory of Immunobiology, Université Libre de Bruxelles (ULB), Gosselies, Belgium., Goriely S; Laboratory of Immunobiology, Université Libre de Bruxelles (ULB), Gosselies, Belgium.; Institute for Medical Immunology, Center for Research in Immunology (U-CRI), Université Libre de Bruxelles (ULB), Gosselies, Belgium., Oldenhove G; Laboratory of Immunobiology, Université Libre de Bruxelles (ULB), Gosselies, Belgium., Moser M; Laboratory of Immunobiology, Université Libre de Bruxelles (ULB), Gosselies, Belgium.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Mar 13; Vol. 14, pp. 1023064. Date of Electronic Publication: 2023 Mar 13 (Print Publication: 2023).

Immune Microenvironment and the Effect of Vascular Endothelial Growth Factor Inhibition in Hepatocellular Carcinoma.

Autor: Oura, Kyoko¹ (AUTHOR) oura.kyoko@kagawa-u.ac.jp, Morishita, Asahiro¹ (AUTHOR) morishita.asahiro@kagawa-u.ac.jp, Tadokoro, Tomoko¹ (AUTHOR), Fujita, Koji¹ (AUTHOR), Tani, Joji¹ (AUTHOR), Kobara, Hideki¹ (AUTHOR)

Publikováno v: International Journal of Molecular Sciences. Dec2024, Vol. 25 Issue 24, p13590. 18p.

The RNA-binding protein tristetraprolin regulates RALDH2 expression by intestinal dendritic cells and controls local Treg homeostasis.

Autor: La C; Institute for Medical Immunology, Université Libre de Bruxelles, Gosselies, Belgium.; ULB Center for Research in Immunology (U-CRI), Gosselies, Belgium., de Toeuf B; ULB Center for Research in Immunology (U-CRI), Gosselies, Belgium.; Laboratoire de Biologie Moléculaire du Gène, Université Libre de Bruxelles, Gosselies, Belgium., Bindels LB; Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium., Van Maele L; Institute for Medical Immunology, Université Libre de Bruxelles, Gosselies, Belgium.; ULB Center for Research in Immunology (U-CRI), Gosselies, Belgium., Assabban A; Institute for Medical Immunology, Université Libre de Bruxelles, Gosselies, Belgium.; ULB Center for Research in Immunology (U-CRI), Gosselies, Belgium., Melchior M; Institute for Medical Immunology, Université Libre de Bruxelles, Gosselies, Belgium.; ULB Center for Research in Immunology (U-CRI), Gosselies, Belgium., Smout J; Institute for Medical Immunology, Université Libre de Bruxelles, Gosselies, Belgium.; ULB Center for Research in Immunology (U-CRI), Gosselies, Belgium., Köhler A; Institute for Medical Immunology, Université Libre de Bruxelles, Gosselies, Belgium.; ULB Center for Research in Immunology (U-CRI), Gosselies, Belgium., Nguyen M; Institute for Medical Immunology, Université Libre de Bruxelles, Gosselies, Belgium.; ULB Center for Research in Immunology (U-CRI), Gosselies, Belgium., Thomas S; Institute for Medical Immunology, Université Libre de Bruxelles, Gosselies, Belgium.; ULB Center for Research in Immunology (U-CRI), Gosselies, Belgium., Soin R; ULB Center for Research in Immunology (U-CRI), Gosselies, Belgium.; Laboratoire de Biologie Moléculaire du Gène, Université Libre de Bruxelles, Gosselies, Belgium., Delacourt N; ULB Center for Research in Immunology (U-CRI), Gosselies, Belgium.; Laboratoire de Biologie Moléculaire du Gène, Université Libre de Bruxelles, Gosselies, Belgium., Li H; ULB Center for Research in Immunology (U-CRI), Gosselies, Belgium.; Laboratoire de Biologie Moléculaire du Gène, Université Libre de Bruxelles, Gosselies, Belgium., Hu W; Department of Biochemistry & Molecular Biology, Mayo Clinic, Rochester, NY, USA., Blackshear PJ; Signal Transduction Laboratory, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA., Kruys V; ULB Center for Research in Immunology (U-CRI), Gosselies, Belgium.; Laboratoire de Biologie Moléculaire du Gène, Université Libre de Bruxelles, Gosselies, Belgium., Gueydan C; ULB Center for Research in Immunology (U-CRI), Gosselies, Belgium.; Laboratoire de Biologie Moléculaire du Gène, Université Libre de Bruxelles, Gosselies, Belgium., Oldenhove G; ULB Center for Research in Immunology (U-CRI), Gosselies, Belgium.; Laboratoire d'Immunobiologie, Université Libre de Bruxelles, Gosselies, Belgium., Goriely S; Institute for Medical Immunology, Université Libre de Bruxelles, Gosselies, Belgium. stanislas.goriely@ulb.be.; ULB Center for Research in Immunology (U-CRI), Gosselies, Belgium. stanislas.goriely@ulb.be.

Publikováno v: Mucosal immunology [Mucosal Immunol] 2021 Jan; Vol. 14 (1), pp. 80-91. Date of Electronic Publication: 2020 May 28.