ATR targeting by the novel inhibitor VE-822 selectively sensitizes pancreatic cancer cells and tumors to radiation and chemoradiation

Autor: Fokas, E, Prevo, R, Pollard, JR, Reaper, PM, Charlton, P, Cornelissen, B, Vallis, K, Hammond, EM, Olcina, MM, Mckenna, WG, Muschel, RJ, Brunner, TB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a5c3c5d10303b73633cd6e547a4f78e1
https://ora.ox.ac.uk/objects/uuid:84b5c842-7166-4396-9488-bc82f017b8de

Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1.

Autor: Beach C; Department of Oncology, University of Oxford, Oxford, United Kingdom., MacLean D; Department of Oncology, University of Oxford, Oxford, United Kingdom., Majorova D; Department of Oncology, University of Oxford, Oxford, United Kingdom., Melemenidis S; Department of Radiation Oncology, Stanford University, Stanford, California, USA., Nambiar DK; Department of Radiation Oncology, Stanford University, Stanford, California, USA., Kim RK; Department of Radiation Oncology, Stanford University, Stanford, California, USA., Valbuena GN; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Guglietta S; Department of Regenerative Medicine and Cell Biology.; Hollings Cancer Center, and., Krieg C; Hollings Cancer Center, and.; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA., Darvish-Damavandi M; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom., Suwa T; Department of Oncology, University of Oxford, Oxford, United Kingdom., Easton A; Department of Oncology, University of Oxford, Oxford, United Kingdom., Hillson LV; School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom., McCulloch AK; School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom., McMahon RK; School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom., Pennel K; School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom., Edwards J; School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom., O'Cathail SM; School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom., Roxburgh CS; School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom., Domingo E; Department of Oncology, University of Oxford, Oxford, United Kingdom., Moon EJ; Department of Oncology, University of Oxford, Oxford, United Kingdom.; Department of Radiation Oncology, Stanford University, Stanford, California, USA., Jiang D; The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Jiang Y; Department of Oncology, University of Oxford, Oxford, United Kingdom., Zhang Q; Department of Oncology, University of Oxford, Oxford, United Kingdom., Koong AC; The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Woodruff TM; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia., Graves EE; Department of Radiation Oncology, Stanford University, Stanford, California, USA., Maughan T; Department of Oncology, University of Oxford, Oxford, United Kingdom., Buczacki SJ; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom., Stucki M; Department of Gynecology, University of Zurich, Schlieren, Switzerland., Le QT; Department of Radiation Oncology, Stanford University, Stanford, California, USA., Leedham SJ; Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom., Giaccia AJ; Department of Oncology, University of Oxford, Oxford, United Kingdom.; Department of Radiation Oncology, Stanford University, Stanford, California, USA., Olcina MM; Department of Oncology, University of Oxford, Oxford, United Kingdom.; Department of Radiation Oncology, Stanford University, Stanford, California, USA.; Department of Gynecology, University of Zurich, Schlieren, Switzerland.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2023 Dec 01; Vol. 133 (23). Date of Electronic Publication: 2023 Dec 01.

The effects of radiation therapy on the macrophage response in cancer.

Autor: Beach C; Department of Oncology, Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom., MacLean D; Department of Oncology, Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom., Majorova D; Department of Oncology, Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom., Arnold JN; School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom., Olcina MM; Department of Oncology, Medical Research Council Oxford Institute for Radiation Oncology, University of Oxford, Oxford, United Kingdom.

Publikováno v: Frontiers in oncology [Front Oncol] 2022 Sep 29; Vol. 12, pp. 1020606. Date of Electronic Publication: 2022 Sep 29 (Print Publication: 2022).

The importance of hypoxia in radiotherapy for the immune response, metastatic potential and FLASH-RT.

Autor: Moon EJ; MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK., Petersson K; MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK.; Radiation Physics, Department of Haematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden., Olcina MM; MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK.

Publikováno v: International journal of radiation biology [Int J Radiat Biol] 2022; Vol. 98 (3), pp. 439-451. Date of Electronic Publication: 2021 Nov 02.

Intracellular C4BPA Levels Regulate NF-κB-Dependent Apoptosis.

Autor: Olcina MM; Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.; Department of Gynecology, University of Zurich, Wagistrasse 14, 8952 Schlieren, Switzerland., Kim RK; Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA., Balanis NG; Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Li CG; Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA., von Eyben R; Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA., Graeber TG; Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, CA, USA., Ricklin D; Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland., Stucki M; Department of Gynecology, University of Zurich, Wagistrasse 14, 8952 Schlieren, Switzerland., Giaccia AJ; Department of Radiation Oncology, Stanford University, Stanford, CA 94305, USA.; Oxford Institute of Radiation Oncology, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX37DQ, UK.

Publikováno v: IScience [iScience] 2020 Sep 21; Vol. 23 (10), pp. 101594. Date of Electronic Publication: 2020 Sep 21 (Print Publication: 2020).