Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Olawale G. Raimi"'
Autor:
Yao Zhou, Kaizhou Yan, Qijian Qin, Olawale G. Raimi, Chao Du, Bin Wang, Chukwuemeka Samson Ahamefule, Bartosz Kowalski, Cheng Jin, Daan M. F. van Aalten, Wenxia Fang
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Aspergillus fumigatus is a devastating opportunistic fungal pathogen causing hundreds of thousands of deaths every year. Phosphoglucose isomerase (PGI) is a glycolytic enzyme that converts glucose-6-phosphate to fructose-6-phosphate, a key p
Externí odkaz:
https://doaj.org/article/35b7683a45a5434ca20a82b41dcf8cdb
Autor:
Poonam Kakade, Hina Ojha, Olawale G. Raimi, Andrew Shaw, Andrew D. Waddell, James R. Ault, Sophie Burel, Kathrin Brockmann, Atul Kumar, Mohd Syed Ahangar, Ewelina M. Krysztofinska, Thomas Macartney, Richard Bayliss, Julia C. Fitzgerald, Miratul M. K. Muqit
Publikováno v:
Open Biology, Vol 12, Iss 1 (2022)
Autosomal recessive mutations in the PINK1 gene are causal for Parkinson's disease (PD). PINK1 encodes a mitochondrial localized protein kinase that is a master-regulator of mitochondrial quality control pathways. Structural studies to date have elab
Externí odkaz:
https://doaj.org/article/676e5fcd8544472ba7c52603d7ecf995
Autor:
Daan M. F. Van Aalten, Cheng Jin, Karina Mariño, Adel F. M. Ibrahim, Osama Albarbarawi, Michael A. J. Ferguson, Ting Du, Olawale G. Raimi, Ramón Hurtado‑Guerrero, Wenxia Fang
Publikováno v:
Bioscience Reports, Vol 33, Iss 5, p e00063 (2013)
Aspergillus fumigatus is the causative agent of IA (invasive aspergillosis) in immunocompromised patients. It possesses a cell wall composed of chitin, glucan and galactomannan, polymeric carbohydrates synthesized by processive glycosyltransferases f
Externí odkaz:
https://doaj.org/article/a22c7bc71e6048d6be793ac8e844875e
Autor:
Atul Kumar, Jevgenia Tamjar, Andrew D Waddell, Helen I Woodroof, Olawale G Raimi, Andrew M Shaw, Mark Peggie, Miratul MK Muqit, Daan MF van Aalten
Publikováno v:
eLife, Vol 6 (2017)
Mutations in the human kinase PINK1 (hPINK1) are associated with autosomal recessive early-onset Parkinson's disease (PD). hPINK1 activates Parkin E3 ligase activity, involving phosphorylation of ubiquitin and the Parkin ubiquitin-like (Ubl) domain v
Externí odkaz:
https://doaj.org/article/20fff1131a3e4ec08eaeefa1982c53ca
Autor:
Kaizhou Yan, Mathew Stanley, Bartosz Kowalski, Olawale G. Raimi, Andrew T. Ferenbach, Pingzhen Wei, Wenxia Fang, Daan M.F. van Aalten
Publikováno v:
The Journal of biological chemistry. 298(6)
Aspergillus fumigatus is the causative agent of invasive aspergillosis, an infection with mortality rates of up to 50%. The glucan-rich cell wall of A. fumigatus is a protective structure that is absent from human cells and is a potential target for
Autor:
Miratul M. K. Muqit, Richard Bayliss, Thomas Macartney, James R. Ault, Ewelina Krysztofinska, Olawale G. Raimi, Poonam S. Kakade, Andrew M. Shaw, Atul Kumar, Kathrin Brockmann, Andrew D. Waddell, Sophie Burel, Mohd Ahanger, Hina Ojha, Julia C. Fitzgerald
Publikováno v:
Open Biology, Vol 12, Iss 1 (2022)
Open biology 12(1), 210264 (2022). doi:10.1098/rsob.210264
Open Biology
Open biology 12(1), 210264 (2022). doi:10.1098/rsob.210264
Open Biology
Human autosomal recessive mutations in the PINK1 gene are causal for Parkinson’s disease (PD). PINK1 encodes a mitochondrial localised protein kinase that is a master-regulator of mitochondrial quality control pathways. Structural studies to date h
Autor:
David A. Robinson, Daniel R. Squair, Dominika Boldovjakova, Andrew T. Ferenbach, Daan M. F. van Aalten, Deborah E. A. Lockhart, Mathew Stanley, Olawale G. Raimi, Wenxia Fang
Publikováno v:
The Journal of Biological Chemistry
'Journal of Biological Chemistry ', vol: 295, pages: 8678-8691 (2020)
'Journal of Biological Chemistry ', vol: 295, pages: 8678-8691 (2020)
Aspergillus fumigatus is a human opportunistic fungal pathogen whose cell wall protects it from the extracellular environment including host defenses. Chitin, an essential component of the fungal cell wall, is synthesized from UDP-GlcNAc produced in
Autor:
Daan M. F. van Aalten, Ramon Hurtado-Guerrero, Michael A. J. Ferguson, Michael D. Urbaniak, Andrew T. Ferenbach, Vladimir S. Borodkin, Olawale G. Raimi
Publikováno v:
RSC Chemical Biology
'RSC Chemical Biology ', vol: 1, pages: 13-25 (2020)
'RSC Chemical Biology ', vol: 1, pages: 13-25 (2020)
UDP-N-acetylglucosamine pyrophosphorylase (UAP1) catalyses the last step in eukaryotic biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc), converting UTP and GlcNAc-1P to the sugar nucleotide. Gene disruption studies have shown that
Autor:
Ling Lu, Olawale G. Raimi, Wenxia Fang, Andrew T. Ferenbach, Deborah E. A. Lockhart, Daan M. F. van Aalten, Yuanwei Zhang
Publikováno v:
Molecular Microbiology.
Aspergillus fumigatus is an opportunistic mold responsible for severe life-threatening fungal infections in immunocompromised patients. The cell wall, an essential structure composed of glucan, chitin, and galactomannan, is considered to be a target
Publikováno v:
Febs Letters
O-GlcNAcylation is a post-translational modification catalysed by O-GlcNAc transferase (OGT). Missense mutations in OGT have been associated with developmental disorders, OGT-linked congenital disorder of glycosylation (OGT-CDG), which are characteri