Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Olav M. Andersen"'
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-36 (2022)
Abstract The family of VPS10p-Domain (D) receptors comprises five members named SorLA, Sortilin, SorCS1, SorCS2 and SorCS3. While their physiological roles remain incompletely resolved, they have been recognized for their signaling engagements and tr
Externí odkaz:
https://doaj.org/article/25b186b51a314fec9dfe61c06a292178
Autor:
Maj Ulrichsen, Nádia P. Gonçalves, Simin Mohseni, Simone Hjæresen, Thomas L. Lisle, Simon Molgaard, Niels K. Madsen, Olav M. Andersen, Åsa F. Svenningsen, Simon Glerup, Anders Nykjær, Christian B. Vægter
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Peripheral nerve regeneration relies on the ability of Schwann cells to support the regrowth of damaged axons. Schwann cells re-differentiate when reestablishing contact with the sprouting axons, with large fibers becoming remyelinated and small noci
Externí odkaz:
https://doaj.org/article/bcae94cc172b4370bc61ba92c676e879
Autor:
Giulia Monti, Mads Kjolby, Anne Mette G. Jensen, Mariet Allen, Juliane Reiche, Peter L. Møller, Raquel Comaposada-Baró, Bartlomiej E. Zolkowski, Cármen Vieira, Margarita Melnikova Jørgensen, Ida E. Holm, Paul N. Valdmanis, Niels Wellner, Christian B. Vægter, Sarah J. Lincoln, Anders Nykjær, Nilüfer Ertekin-Taner, Jessica E. Young, Mette Nyegaard, Olav M. Andersen
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-18 (2021)
Abstract SORL1 is strongly associated with both sporadic and familial forms of Alzheimer’s disease (AD), but a lack of information about alternatively spliced transcripts currently limits our understanding of the role of SORL1 in AD. Here, we descr
Externí odkaz:
https://doaj.org/article/6593f8c6612a4dd48b7424bbb99fda5f
Autor:
Mika Pietilä, Pranshu Sahgal, Emilia Peuhu, Niklas Z. Jäntti, Ilkka Paatero, Elisa Närvä, Hussein Al-Akhrass, Johanna Lilja, Maria Georgiadou, Olav M. Andersen, Artur Padzik, Harri Sihto, Heikki Joensuu, Matias Blomqvist, Irena Saarinen, Peter J. Boström, Pekka Taimen, Johanna Ivaska
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The EGF receptor HER2 is an oncogene protein thought to reside at the plasma membrane, but its endosomal trafficking is currently unclear. Here, the authors report that HER2 is endocytosed and that sortillin-related receptor 1 (SORLA) promotes endoso
Externí odkaz:
https://doaj.org/article/b28b871b1d0643feb58c297bc60c61de
Autor:
Nádia P. Gonçalves, Simin Mohseni, Marwa El Soury, Maj Ulrichsen, Mette Richner, Junhua Xiao, Rhiannon J. Wood, Olav M. Andersen, Elizabeth J. Coulson, Stefania Raimondo, Simon S. Murray, Christian B. Vægter
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Schwann cell reprogramming and differentiation are crucial prerequisites for neuronal regeneration and re-myelination to occur following injury to peripheral nerves. The neurotrophin receptor p75NTR has been identified as a positive modulator for Sch
Externí odkaz:
https://doaj.org/article/e730f8d20bf64674989c26d7b2e763df
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 10, Pp 2763-2774 (2013)
The lipoprotein receptor (LR) family constitutes a large group of structurally closely related receptors with broad ligand-binding specificity. Traditionally, ligand binding to LRs has been anticipated to involve merely the complement type repeat (CR
Externí odkaz:
https://doaj.org/article/7cd0ee247b8c46c287e9e2ea75a660db
Autor:
Paulina Kaminska, Peter L. Ovesen, Mateusz Jakiel, Tomasz Obrebski, Vanessa Schmidt, Magdalena Bieniek, Jasper Anink, Bohdan Paterczyk, Michal Draminski, Anne Mette Gissel Jensen, Sylwia Piatek, Olav M. Andersen, Eleonora Aronica, Thomas E. Willnow, Bozena Kaminska, Michal J. Dabrowski, Anna R. Malik
SorLA, encoded by the geneSORL1, is an intracellular sorting receptor of the VPS10P domain receptor gene family. Although SorLA is best recognized for its ability to shuttle target proteins between intracellular compartments in neurons, recent data s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::363d1639ef084bea7d7fc8a8ae5f74b3
https://doi.org/10.1101/2023.04.12.536447
https://doi.org/10.1101/2023.04.12.536447
Autor:
Olav M. Andersen, Giulia Monti, Anne Mette G. Jensen, Matthijs de Waal, Marc Hulsman, Johan G. Olsen, Henne Holstege
SORL1encodes the retromer-associated receptor SORLA that functions in endosomal recycling. Rare variants inSORL1have been associated with Alzheimer’s disease (AD) and rare pathogenic variants are estimated to occur in up to 2.75% of early onset AD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e9fc8b6497ff8835ade4f6bd1b938dc
https://doi.org/10.1101/2023.02.27.524103
https://doi.org/10.1101/2023.02.27.524103
Autor:
Anne Mette G. Jensen, Yu Kitago, Elnaz Fazeli, Christian B. Vægter, Scott A. Small, Gregory A. Petsko, Olav M. Andersen
Publikováno v:
Jensen, A M G, Kitago, Y, Fazeli, E, Vægter, C B, Small, S A, Petsko, G A & Andersen, O M 2023, ' Dimerization of the Alzheimer's disease pathogenic receptor SORLA regulates its association with retromer ', Proceedings of the National Academy of Sciences, vol. 120, no. 4, e2212180120 . https://doi.org/10.1073/pnas.2212180120
SORL1 , the gene encoding the large multidomain SORLA protein, has emerged as only the fourth gene that when mutated can by itself cause Alzheimer’s disease (AD), and as a gene reliably linked to both the early- and late-onset forms of the disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789be2709cc6de06e9087452c46e1ba1
https://pure.au.dk/portal/da/publications/dimerization-of-the-alzheimers-disease-pathogenic-receptor-sorla-regulates-its-association-with-retromer(4cd16520-6b3c-4451-acc7-b0fd6b8859e4).html
https://pure.au.dk/portal/da/publications/dimerization-of-the-alzheimers-disease-pathogenic-receptor-sorla-regulates-its-association-with-retromer(4cd16520-6b3c-4451-acc7-b0fd6b8859e4).html
Autor:
Olav M. Andersen, Nikolaj Bøgh, Anne M. Landau, Gro G. Pløen, Anne Mette G. Jensen, Giulia Monti, Benedicte P. Ulhøi, Jens R. Nyengaard, Kirsten R. Jacobsen, Margarita M. Jørgensen, Ida E. Holm, Marianne L. Kristensen, Aage Kristian O. Alstrup, Esben S.S. Hansen, Charlotte E. Teunissen, Laura Breidenbach, Mathias Droescher, Ying Liu, Hanne S. Pedersen, Henrik Callesen, Yonglun Luo, Lars Bolund, David J. Brooks, Christoffer Laustsen, Scott A. Small, Lars F. Mikkelsen, Charlotte B. Sørensen
Publikováno v:
Andersen, O M, Bøgh, N, Landau, A M, Pløen, G G, Jensen, A M G, Monti, G, Ulhøi, B P, Nyengaard, J R, Jacobsen, K R, Jørgensen, M M, Holm, I E, Kristensen, M L, Alstrup, A K O, Hansen, E S S, Teunissen, C E, Breidenbach, L, Droescher, M, Liu, Y, Pedersen, H S, Callesen, H, Luo, Y, Bolund, L, Brooks, D J, Laustsen, C, Small, S A, Mikkelsen, L F & Sørensen, C B 2022, ' A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency ', Cell reports. Medicine, vol. 3, no. 9, 100740 . https://doi.org/10.1016/j.xcrm.2022.100740
Andersen, O M, Bøgh, N, Landau, A M, Pløen, G G, Jensen, A M G, Monti, G, Ulhøi, B P, Nyengaard, J R, Jacobsen, K R, Jørgensen, M M, Holm, I E, Kristensen, M L, Alstrup, A K O, Hansen, E S S, Teunissen, C E, Breidenbach, L, Droescher, M, Liu, Y, Pedersen, H S, Callesen, H, Luo, Y, Bolund, L, Brooks, D J, Laustsen, C, Small, S A, Mikkelsen, L F & Sørensen, C B 2022, ' A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency ', Cell Reports Medicine, vol. 3, no. 9, 100740 . https://doi.org/10.1016/j.xcrm.2022.100740
Cell Reports Medicine, 3(9):100740. Cell Press
Andersen, O M, Bøgh, N, Landau, A M, Pløen, G G, Jensen, A M G, Monti, G, Ulhøi, B P, Nyengaard, J R, Jacobsen, K R, Jørgensen, M M, Holm, I E, Kristensen, M L, Alstrup, A K O, Hansen, E S S, Teunissen, C E, Breidenbach, L, Droescher, M, Liu, Y, Pedersen, H S, Callesen, H, Luo, Y, Bolund, L, Brooks, D J, Laustsen, C, Small, S A, Mikkelsen, L F & Sørensen, C B 2022, ' A genetically modified minipig model for Alzheimer's disease with SORL1 haploinsufficiency ', Cell Reports Medicine, vol. 3, no. 9, 100740 . https://doi.org/10.1016/j.xcrm.2022.100740
Cell Reports Medicine, 3(9):100740. Cell Press
The established causal genes in Alzheimer's disease (AD), APP, PSEN1, and PSEN2, are functionally characterized using biomarkers, capturing an in vivo profile reflecting the disease's initial preclinical phase. Mutations in SORL1, encoding the endoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::692217e27d26c70f47e5caa412c77719
https://vbn.aau.dk/da/publications/871f36d7-57e4-414a-9919-50f1b6541ce5
https://vbn.aau.dk/da/publications/871f36d7-57e4-414a-9919-50f1b6541ce5