Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Olav B. Ryan"'
Autor:
Katrine Wickstroem, Jenny Karlsson, Christine Ellingsen, Véronique Cruciani, Alexander Kristian, Urs B. Hagemann, Roger M. Bjerke, Olav B. Ryan, Lars Linden, Dominik Mumberg, Michael Brands, Alan Cuthbertson
Publikováno v:
Pharmaceuticals, Vol 12, Iss 4, p 155 (2019)
Targeted thorium-227 conjugates (TTCs) represent a novel class of therapeutic radiopharmaceuticals for the treatment of cancer. TTCs consist of the alpha particle emitter thorium-227 complexed to a 3,2-hydroxypyridinone chelator conjugated to a tumor
Externí odkaz:
https://doaj.org/article/b8cca3f3975a483da162b55cd3120c53
Autor:
Cuthbertson, Jenny Karlsson, Urs B. Hagemann, Véronique Cruciani, Christoph A. Schatz, Derek Grant, Christine Ellingsen, Alexander Kristian, Shirin Katoozi, Dessislava Mihaylova, Steinar R. Uran, Mari Suominen, Roger M. Bjerke, Olav B. Ryan, Alan
Publikováno v:
Cancers; Volume 15; Issue 13; Pages: 3419
Human epidermal growth factor receptor 2 (HER2) is overexpressed in 15–30% of breast cancers but has low expression in normal tissue, making it attractive for targeted alpha therapy (TAT). HER2-positive breast cancer typically metastasizes to bone,
Autor:
Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann
The clinical efficacy of the first approved alpha pharmaceutical, Xofigo (radium-223 dichloride, 223RaCl2), has stimulated significant interest in the development of new alpha-particle emitting drugs in oncology. Unlike radium-223 (223Ra), the parent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e35ca4b99143e9db09cefc4dfb3643
https://doi.org/10.1158/1535-7163.c.6537598.v1
https://doi.org/10.1158/1535-7163.c.6537598.v1
Autor:
Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann
Blood samples from animals treated with vehicle and CD33-TTC, administered at the different dose levels, were taken at Day -1, Day 67 and Day 123. (A) White blood cell counts, expressed in 109/L. (B) Red blood cell counts, expressed in 1012/L.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e61add3f7aa0bbca94cc30520932a5
https://doi.org/10.1158/1535-7163.22504039.v1
https://doi.org/10.1158/1535-7163.22504039.v1
Autor:
Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann
Supplementary figure legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361388845c3296c2208652b4c5f1bd17
https://doi.org/10.1158/1535-7163.22504033
https://doi.org/10.1158/1535-7163.22504033
Autor:
Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann
Thorium-227 is purified from actinium-227 (227Ac). Thorium-227 decays via its alpha- and beta-emitting daughters to stable nonradioactive 207Pb. The energy emitted at each decay step (in MeV) are summarized. When thorium-227 decays to radium-223, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f22fb266f9a191731b0ff6f2d053ec
https://doi.org/10.1158/1535-7163.22504045
https://doi.org/10.1158/1535-7163.22504045
Autor:
Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann
Isolated kidneys (A, B) and bone marrow (C, D) were co-stained with a CD33-specific antibody (A, C) and a CD45-specific antibody (B, D).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208fb2fc7d4c3690db8486abc7ecb072
https://doi.org/10.1158/1535-7163.22504036
https://doi.org/10.1158/1535-7163.22504036
Autor:
Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Kristine Sponheim, Adam O. Shea, Ellen Wang, Katrine Wickstroem, Urs B. Hagemann
Binding of CD33 antibody and CD33 antibody chelator-conjugate to CD33-positive HL-60 cells by FACS staining in comparison to an isotype control. Bound antibodies were detected using secondary PE-labeled anti-human antibody. Median fluorescence intens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86281a6228865dcc88f6a91470e14717
https://doi.org/10.1158/1535-7163.22504042
https://doi.org/10.1158/1535-7163.22504042
Autor:
Dominik Mumberg, Alan S. Cuthbertson, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Hartwig Hennekes, Pascale Lejeune, Alexander Kristian, Oliver von Ahsen, Roger Smeets, Baard Indrevoll, Derek Grant, Solene Geraudie, Christine Ellingsen, Aasmund Larsen, Sabine Zitzmann-Kolbe, Urs B. Hagemann, Stefanie Hammer
Purpose:Prostate-specific membrane antigen (PSMA) is an attractive target for radionuclide therapy of metastatic castration-resistant prostate cancer (mCRPC). PSMA-targeted alpha therapy (TAT) has shown early signs of activity in patients with prosta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a23d1ef6906be1f9af8869880f63e4
https://doi.org/10.1158/1078-0432.c.6529694
https://doi.org/10.1158/1078-0432.c.6529694
Autor:
Alan S. Cuthbertson, Karl Ziegelbauer, Dominik Mumberg, Olav B. Ryan, Roger M. Bjerke, Jenny Karlsson, Hartwig Hennekes, Steinar Uran, Roger Smeets, Sven Golfier, Christoph Kneip, Christoph A. Schatz, Katrine Wickstroem, Véronique Cruciani, Anne Mobergslien, Alexander Kristian, Joachim Schuhmacher, Christine Ellingsen, Urs B. Hagemann
The file contains Supporting Figures.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01f92bea6c9a4be445515d2bb9d07c53
https://doi.org/10.1158/1078-0432.22469934.v1
https://doi.org/10.1158/1078-0432.22469934.v1