Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Olav B, Smeland"'
Autor:
Shahram Bahrami, Kaja Nordengen, Jaroslav Rokicki, Alexey A. Shadrin, Zillur Rahman, Olav B. Smeland, Piotr P. Jaholkowski, Nadine Parker, Pravesh Parekh, Kevin S. O’Connell, Torbjørn Elvsåshagen, Mathias Toft, Srdjan Djurovic, Anders M. Dale, Lars T. Westlye, Tobias Kaufmann, Ole A. Andreassen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The basal ganglia are subcortical brain structures involved in motor control, cognition, and emotion regulation. We conducted univariate and multivariate genome-wide association analyses (GWAS) to explore the genetic architecture of basal ga
Externí odkaz:
https://doaj.org/article/2f1f263ef851499c8530865075d76cf0
Autor:
Olivia Wootton, Alexey A. Shadrin, Thomas Bjella, Olav B. Smeland, Dennis van der Meer, Oleksandr Frei, Kevin S. O’Connell, Torill Ueland, Ole A. Andreassen, Dan J. Stein, Shareefa Dalvie
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Cognitive impairment is a major determinant of functional outcomes in schizophrenia, however, understanding of the biological mechanisms underpinning cognitive dysfunction in the disorder remains incomplete. Here, we apply Genomic Structural
Externí odkaz:
https://doaj.org/article/7f13ff9d04ba4cabb368c63148f5460b
Autor:
Lasse Bang, Shahram Bahrami, Guy Hindley, Olav B. Smeland, Linn Rødevand, Piotr P. Jaholkowski, Alexey Shadrin, Kevin S. O’ Connell, Oleksandr Frei, Aihua Lin, Zillur Rahman, Weiqiu Cheng, Nadine Parker, Chun C. Fan, Anders M. Dale, Srdjan Djurovic, Cynthia M. Bulik, Ole A. Andreassen
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Anorexia nervosa (AN) is a heritable eating disorder (50–60%) with an array of commonly comorbid psychiatric disorders and related traits. Although significant genetic correlations between AN and psychiatric disorders and related traits ha
Externí odkaz:
https://doaj.org/article/1504dcdb9170486786ab8df09684f946
Autor:
Markos Tesfaye, Piotr Jaholkowski, Guy F. L. Hindley, Alexey A. Shadrin, Zillur Rahman, Shahram Bahrami, Aihua Lin, Børge Holen, Nadine Parker, Weiqiu Cheng, Linn Rødevand, Oleksandr Frei, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Kevin S. O’Connell, Ole A. Andreassen
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-18 (2023)
Abstract Background Irritable bowel syndrome (IBS) often co-occurs with psychiatric and gastrointestinal disorders. A recent genome-wide association study (GWAS) identified several genetic risk variants for IBS. However, most of the heritability rema
Externí odkaz:
https://doaj.org/article/d4cf61f95eec4b69bd69fd5c62edd34e
Autor:
Hao Wang, Carolina Makowski, Yanxiao Zhang, Anna Qi, Tobias Kaufmann, Olav B. Smeland, Mark Fiecas, Jian Yang, Peter M. Visscher, Chi-Hua Chen
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112896- (2023)
Summary: The impact of chromosomal inversions on human brain morphology remains underexplored. We studied 35 common inversions classified from genotypes of 33,018 adults with European ancestry. The inversions at 2p22.3, 16p11.2, and 17q21.31 reach ge
Externí odkaz:
https://doaj.org/article/49a737db4c2d4eadac090dcf494e573c
Autor:
Fabian Streit, Stephanie H. Witt, Swapnil Awasthi, Jerome C. Foo, Martin Jungkunz, Josef Frank, Lucía Colodro-Conde, Guy Hindley, Olav B. Smeland, Tolou Maslahati, Cornelia E. Schwarze, Norbert Dahmen, Björn H. Schott, Nikolaus Kleindienst, Annette Hartmann, Ina Giegling, Lea Zillich, Lea Sirignano, Eric Poisel, Chi-Hua Chen, Markus M. Nöthen, Arian Mobascher, Dan Rujescu, Klaus Lieb, Stefan Roepke, Christian Schmahl, Martin Bohus, Stephan Ripke, Marcella Rietschel, Ole A. Andreassen
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Both environmental (e.g. interpersonal traumatization during childhood and adolescence) and genetic factors may contribute to the development of Borderline Personality Disorder (BPD). Twin studies assessing borderline personality symptoms/fe
Externí odkaz:
https://doaj.org/article/0a56719c0a544662bd735b31630c3168
Autor:
Attila Szabo, Ibrahim A. Akkouh, Matthieu Vandenberghe, Jordi Requena Osete, Timothy Hughes, Vivi Heine, Olav B. Smeland, Joel C. Glover, Ole A. Andreassen, Srdjan Djurovic
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract While neurodevelopmental abnormalities have been associated with schizophrenia (SCZ), the role of astroglia in disease pathophysiology remains poorly understood. In the present study, we used a human induced pluripotent stem cell (iPSC)-deri
Externí odkaz:
https://doaj.org/article/15f6e60079fa4543be5cc7f80fc3bf5a
Autor:
Guy Hindley, Shahram Bahrami, Nils Eiel Steen, Kevin S. O’Connell, Oleksandr Frei, Alexey Shadrin, Francesco Bettella, Linn Rødevand, Chun C. Fan, Anders M. Dale, Srdjan Djurovic, Olav B. Smeland, Ole A. Andreassen
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Increased risk-taking is a central component of bipolar disorder (BIP) and is implicated in schizophrenia (SCZ). Risky behaviours, including smoking and alcohol use, are overrepresented in both disorders and associated with poor health outco
Externí odkaz:
https://doaj.org/article/c366b87c22cf4cc282473524c3c42ec0
Autor:
Linn Rødevand, Shahram Bahrami, Oleksandr Frei, Yunhan Chu, Alexey Shadrin, Kevin S. O’Connell, Olav B. Smeland, Torbjørn Elvsåshagen, Guy F. L. Hindley, Srdjan Djurovic, Anders M. Dale, Trine V. Lagerberg, Nils Eiel Steen, Ole A. Andreassen
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Patients with bipolar disorder (BIP) have a high risk of cardiovascular disease (CVD), despite considerable individual variation. The mechanisms underlying comorbid CVD in BIP remain largely unknown. We investigated polygenic overlap between
Externí odkaz:
https://doaj.org/article/df29ce5597ec4670ae2c6751050c2698
Autor:
Kristin Torgersen, Shahram Bahrami, Oleksandr Frei, Alexey Shadrin, Kevin S. O’ Connell, Olav B. Smeland, John Munkhaugen, Srdjan Djurovic, Toril Dammen, Ole A. Andreassen
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Neuroticism is associated with poor health, cardiovascular disease (CVD) risk factors and coronary artery disease (CAD). The conditional/conjunctional false discovery rate method (cond/conjFDR) was applied to genome wide association study (G
Externí odkaz:
https://doaj.org/article/058cfe981cbe4b8dbabf76efc4bdc953