Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Olasunkanmi O, Olaoye"'
Autor:
Helena Sorger, Saptaswa Dey, Pablo Augusto Vieyra‐Garcia, Daniel Pölöske, Andrea R Teufelberger, Elvin D deAraujo, Abootaleb Sedighi, Ricarda Graf, Benjamin Spiegl, Isaac Lazzeri, Till Braun, Ines Garces de los Fayos Alonso, Michaela Schlederer, Gerald Timelthaler, Petra Kodajova, Christine Pirker, Marta Surbek, Michael Machtinger, Thomas Graier, Isabella Perchthaler, Yi Pan, Regina Fink‐Puches, Lorenzo Cerroni, Jennifer Ober, Moritz Otte, Jana D Albrecht, Gary Tin, Ayah Abdeldayem, Pimyupa Manaswiyoungkul, Olasunkanmi O Olaoye, Martin L Metzelder, Anna Orlova, Walter Berger, Marion Wobser, Jan P Nicolay, Fiona André, Van Anh Nguyen, Heidi A Neubauer, Roman Fleck, Olaf Merkel, Marco Herling, Ellen Heitzer, Patrick T Gunning, Lukas Kenner, Richard Moriggl, Peter Wolf
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 12, Pp n/a-n/a (2022)
Abstract Leukemic cutaneous T‐cell lymphomas (L‐CTCL) are lymphoproliferative disorders of skin‐homing mature T‐cells causing severe symptoms and high mortality through chronic inflammation, tissue destruction, and serious infections. Despite
Externí odkaz:
https://doaj.org/article/c1ee8bac3c164d9b80fc189cf3bc69bf
Autor:
Nabanita Nawar, Shazreh Bukhari, Ashley A. Adile, Yujin Suk, Pimyupa Manaswiyoungkul, Krimo Toutah, Olasunkanmi O. Olaoye, Yasir S. Raouf, Abootaleb Sedighi, Harsimran Kaur Garcha, Muhammad Murtaza Hassan, William Gwynne, Johan Israelian, Tudor B. Radu, Mulu Geletu, Ayah Abdeldayem, Justyna M. Gawel, Aaron D. Cabral, Chitra Venugopal, Elvin D. de Araujo, Sheila K. Singh, Patrick T. Gunning
Publikováno v:
Journal of Medicinal Chemistry. 65:3193-3217
Publikováno v:
Molecules, Vol 25, Iss 10, p 2285 (2020)
The use of light-activated chemical probes to study biological interactions was first discovered in the 1960s, and has since found many applications in studying diseases and gaining deeper insight into various cellular mechanisms involving protein–
Externí odkaz:
https://doaj.org/article/01fb0a8716a645f5a596bcada297932d
Autor:
Qirat F. Ashraf, Erica J. Quilates, Olasunkanmi O. Olaoye, Elvin D. de Araujo, Patrick T. Gunning
Publikováno v:
Methods in Molecular Biology ISBN: 9781071627877
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5eec15bdbd18641dc0e0706d677d2e4
https://doi.org/10.1007/978-1-0716-2788-4_31
https://doi.org/10.1007/978-1-0716-2788-4_31
Autor:
Qirat F, Ashraf, Erica J, Quilates, Olasunkanmi O, Olaoye, Elvin D, de Araujo, Patrick T, Gunning
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2589
Histone deacetylase 6 (HDAC6) is an emerging clinical target for the treatment of several hematological cancers and central nervous system disorders. HDAC6 catalyzes the deacetylation of lysine residues on substrates such as tubulin, with profound im
Autor:
Muhammad Murtaza Hassan, Abootaleb Sedighi, Olasunkanmi O. Olaoye, Cécile Häberli, Annika Merz, Elizabeth Ramos‐Morales, Elvin D. de Araujo, Christophe Romier, Manfred Jung, Jennifer Keiser, Patrick T. Gunning
Publikováno v:
ChemMedChem. 17(18)
Schistosomiasis is a prevalent yet neglected tropical parasitic disease caused by the Schistosoma genus of blood flukes. Praziquantel is the only currently available treatment, hence drug resistance poses a major threat. Recently, histone deacetylase
Autor:
Andrew E. Shouksmith, Abootaleb Sedighi, Yasir S. Raouf, Niyati Kachhiyapatel, Ayah Abdeldayem, Paris R. Watson, Krimo Toutah, Olasunkanmi O. Olaoye, David W. Christianson, Patrick T. Gunning, Shazreh Bukhari, Pimyupa Manaswiyoungkul, Justyna M. Gawel, Aaron D. Cabral, Johan Israelian, Muhammad Murtaza Hassan, Nabanita Nawar, Fettah Erdogan, Elvin D. de Araujo, Tudor B. Radu, Mulu Geletu
Publikováno v:
J Med Chem
Histone deacetylase 6 (HDAC6) is involved in multiple regulatory processes, ranging from cellular stress to intracellular transport. Inhibition of aberrant HDAC6 activity in several cancers and neurological diseases has been shown to be efficacious i
Autor:
Patrick T. Gunning, Yasir S. Raouf, Muhammad Murtaza Hassan, Jana von Jan, Aleksandr Ianevski, Muzaffar N. Bhatti, Justyna M. Gawel, Mulu Geletu, Pimyupa Manaswiyoungkul, Nabanita Nawar, Elvin D. de Araujo, Helena Sorger, Olasunkanmi O. Olaoye, Tero Aittokallio, Oliver H. Krämer, Marco Herling, Sanna Timonen, Ayah Abdeldayem, Krimo Toutah, Tudor B. Radu, Richard Moriggl, Shazreh Bukhari, Johan Israelian, Heidi A. Neubauer, Satu Mustjoki, Andrew E. Shouksmith, Abootaleb Sedighi
Publikováno v:
Journal of Medicinal Chemistry
Epigenetic targeting has emerged as an efficacious therapy for hematological cancers. The rare and incurable T-cell prolymphocytic leukemia (T-PLL) is known for its aggressive clinical course. Current epigenetic agents such as histone deacetylase (HD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3a89d15e76dd9bd052d4a50193efb2
http://hdl.handle.net/10852/93204
http://hdl.handle.net/10852/93204
Autor:
Muhammad Murtaza Hassan, Yasir S. Raouf, Pimyupa Manaswiyoungkul, Aaron D. Cabral, Abootaleb Sedighi, Rabia Altintas, Fettah Erdogan, Patrick T. Gunning, Giovanni Ganda, David W.J. Armstrong, Olasunkanmi O. Olaoye, Elvin D. de Araujo, Johan Israelian, Fabrizio Angeles, Nabanita Nawar
Publikováno v:
Journal of medicinal chemistry. 63(15)
Histone deacetylases (HDACs) are an attractive therapeutic target for a variety of human diseases. Currently, all four FDA-approved HDAC-targeting drugs are nonselective, pan-HDAC inhibitors, exhibiting adverse side effects at therapeutic doses. Alth
Autor:
Abootaleb Sedighi, Yasir S. Raouf, Diana Sina, Krimo Toutah, Johan Israelian, Andrew E. Shouksmith, Patrick T. Gunning, Shazreh Bukhari, Elvin D. de Araujo, Olasunkanmi O. Olaoye, Aaron D. Cabral, Nabanita Nawar, Tudor B. Radu, Justyna M. Gawel, Pimyupa Manaswiyoungkul
Publikováno v:
European journal of medicinal chemistry. 201
Dysregulated Histone Deacetylase (HDAC) activity across multiple human pathologies have highlighted this family of epigenetic enzymes as critical druggable targets, amenable to small molecule intervention. While efficacious, current approaches using