Insertion of Basic Amino Acids in the Hemagglutinin Cleavage Site of H4N2 Avian Influenza Virus (AIV)-Reduced Virus Fitness in Chickens is Restored by Reassortment with Highly Pathogenic H5N1 AIV.

Autor: Gischke M; Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, 17493 Mecklenburg-Vorpommern, Germany., Ulrich R; Department of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, 17493 Mecklenburg-Vorpommern, Germany., I Fatola O; Department of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, 17493 Mecklenburg-Vorpommern, Germany., Scheibner D; Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, 17493 Mecklenburg-Vorpommern, Germany., Salaheldin AH; Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, 17493 Mecklenburg-Vorpommern, Germany.; Department of Poultry Diseases, Faculty of Veterinary Medicine, Alexandria University, Alexandria 22758, Egypt., Crossley B; California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California, Davis, CA 95616, USA., Böttcher-Friebertshäuser E; Institute of Virology, Philipps University Marburg, 35043 Marburg, Germany., Veits J; Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, 17493 Mecklenburg-Vorpommern, Germany., Mettenleiter TC; Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, 17493 Mecklenburg-Vorpommern, Germany., Abdelwhab EM; Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Greifswald-Insel Riems, 17493 Mecklenburg-Vorpommern, Germany.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2020 Mar 28; Vol. 21 (7). Date of Electronic Publication: 2020 Mar 28.