Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Olaia Nieto-García"'
Autor:
Olaia Nieto-García, Ricardo Alonso
Publikováno v:
The Journal of Organic Chemistry. 78:2564-2570
Intramolecular Diels-Alder cycloadditions of chlorofuryl- (R = Cl) secondary (R' = H) acrylamides and propiolamides of type 1 followed by (optional modification and) base-induced aromatization of the resulting chlorinated oxanorborn(adi)enes 2 afford
Autor:
Ricardo Alonso, Olaia Nieto-García
Publikováno v:
Org. Biomol. Chem.. 11:515-522
Access to some 7,9-dideoxy analogues of pancratistatin was achieved by combining our previously reported nitroenal/dioxanone annulation (to form ring C) with a hetero-Diels-Alder/aromatization path to build the dihydroisoquinolinone subunit (rings A
Publikováno v:
The Journal of organic chemistry. 77(24)
2-Methoxymethylpyrrolidine best performed, among several other proline derivatives, to control the enantioselective [3+3] annulation of β-(hetero)aryl-α-nitro-α,β-enals with commercial 2,2-dimethyl-1,3-dioxan-5-one, a procedure that renders highl
Autor:
Fernando Cagide-Fagín, Juan Carlos Ortiz-Lara, Olaia Nieto-García, Ricardo Alonso, Hugo Lago-Santomé
Publikováno v:
Organicbiomolecular chemistry. 10(4)
A full account is given for the total synthesis and the cytotoxic activity against the human lung tumoral cell line NCI-H460 of (±)-7-deoxy-pancratistatin and its 2-epi- and 2,4-diepi- unnatural analogues.
Publikováno v:
Molecular Cancer Therapeutics. 8:A176-A176
One of the biggest hurdles in the fight against cancer is the non-selective nature of most current treatments. On the other hand, opioids-refractive cancer pain is a most important unsolved problem. Consequently, the search and development of new dru
Autor:
Jordi Bertran-Vicente, Martin Penkert, Olaia Nieto-Garcia, Jean-Marc Jeckelmann, Peter Schmieder, Eberhard Krause, Christian P. R. Hackenberger
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Protein phosphorylation mediates signalling and other important cellular processes, but the specific effect of cysteine phosphorylation is unclear. Here, the authors present a chemical strategy to selectively phosphorylate cysteine residues and a mas
Externí odkaz:
https://doaj.org/article/1040c880158d473390673af6b138aded