Insertion of an Amphipathic Linker in a Tetrapodal Tryptophan Derivative Leads to a Novel and Highly Potent Entry Inhibitor of Enterovirus A71 Clinical Isolates

Autor: Olaia Martí-Marí, Rana Abdelnabi, Dominique Schols, Johan Neyts, María-José Camarasa, Federico Gago, Ana San-Félix

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 4, p 3539 (2023)

AL-471, the leading exponent of a class of potent HIV and enterovirus A71 (EV-A71) entry inhibitors discovered in our research group, contains four l-tryptophan (Trp) units bearing an aromatic isophthalic acid directly attached to the C2 position of

Externí odkaz: https://doaj.org/article/082313cde67a407c966bf63dc027464d

Organotropic dendrons with high potency as HIV-1, HIV-2 and EV-A71 cell entry inhibitors

Autor: Olaia Martí-Marí, Belén Martínez-Gualda, Irene Fernández-Barahona, Alberto Mills, Rana Abdelnabi, Sam Noppen, Johan Neyts, Dominique Schols, María-José Camarasa, Fernando Herranz, Federico Gago, Ana San-Félix

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Dedicated to Prof. Dr. Jan Balzarini (KU Leuven, Belgium), in recognition of his exem- plary life-long dedication to virology and con- stant encouragement
We have recently described a novel family of compounds of reduced size and dual anti-HIV a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a11368740abd6c3e2d38130194456bf1
https://pubmed.ncbi.nlm.nih.gov/35512567

Multivalent Tryptophan- and Tyrosine-Containing [60]Fullerene Hexa-Adducts as Dual HIV and Enterovirus A71 Entry Inhibitors

Autor: María-José Camarasa, Arnaud Boonen, Johan Neyts, Olaia Martí-Marí, Rana Abdelnabi, Sam Noppen, Marta Ruiz-Santaquiteria, Nazario Martín, Dominique Schols, Alberto Mills, Beatriz M. Illescas, Ana San-Félix, Federico Gago

Publikováno v: Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia
instname
E-Prints Complutense. Archivo Institucional de la UCM
Chemistry (Weinheim an Der Bergstrasse, Germany)
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC

Unprecedented 3D hexa-adducts of [60]fullerene peripherally decorated with twelve tryptophan (Trp) or tyrosine (Tyr) residues have been synthesized. Studies on the antiviral activity of these novel compounds against HIV and EV71 reveal that they are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e29650daa74da74cbe8fc32f9e2566
http://hdl.handle.net/20.500.12614/2653

Optical control of muscular nicotinic channels with azocuroniums, photoswitchable azobenzenes bearing two N-methyl-N-carbocyclic quaternary ammonium groups

Autor: Concepción Pérez, Clara Herrera-Arozamena, Olaia Martí-Marí, María Isabel Rodríguez-Franco, Mario de la Fuente Revenga, Carlos A. Villalba-Galea, Martín Estrada-Valencia

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

By linking two N-methyl-N-carbocyclic quaternary ammonium groups to an azobenzene scaffold in meta- or para-positions we generated a series of photoswitchable neuromuscular ligands for which we coined the term “azocuroniums”. These compounds swit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf3cdf80ed4edae8f488ee4d249b1d8
http://hdl.handle.net/10261/217685

Modifications in the branched arms of a class of dual inhibitors of HIV and EV71 replication expand their antiviral spectrum

Autor: Ana San-Félix, Leen Delang, Carmen Mirabelli, Liang Sun, Johan Neyts, María-José Camarasa, Dominique Schols, Belén Martínez-Gualda, Olaia Martí-Marí

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Antiviral Research

We have previously reported a new class of dendrimers with tryptophan (Trp) residues on the surface that show dual antiviral activities against HIV and enterovirus EV71. The prototype compound of this family is a derivative of pentaerythritol with 12

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72f499d85dcc0ff407510bd01a6eb38
http://hdl.handle.net/10261/191672