Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Olaf-Georg Issinger"'
Autor:
Olaf-Georg Issinger, Barbara Guerra
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 139, Iss , Pp 111650- (2021)
Protein kinases belong to the largest family of enzymes controlling every aspect of cellular activity including gene expression, cell division, differentiation and metabolism. They are part of major intracellular signalling pathways. Hence, it is not
Externí odkaz:
https://doaj.org/article/17afd6b2a3754f239ba0ba127a37d90d
Autor:
Barbara Guerra, Olaf-Georg Issinger
Publikováno v:
Pharmaceuticals, Vol 13, Iss 10, p 292 (2020)
Uncontrolled proliferation is a feature defining cancer and it is linked to the ability of cancer cells to effectively adapt their metabolic needs in response to a harsh tumor environment. Metabolic reprogramming is considered a hallmark of cancer an
Externí odkaz:
https://doaj.org/article/b1b35862334a46f2beb9274ab6b0e54d
Publikováno v:
Toxicology Reports, Vol 1, Iss C, Pp 1162-1174 (2014)
Pancreatic adenocarcinoma is one of the deadliest human solid tumors in the developed countries characterized by high resistance toward chemotherapeutic treatment. We have previously shown that silencing of the pro-survival protein kinase CK2 by RNA
Externí odkaz:
https://doaj.org/article/c9e96fe332074852a48b9e85c652708a
Autor:
Barbara Guerra, Olaf-Georg Issinger
Publikováno v:
Pharmaceuticals, Vol 12, Iss 1, p 4 (2019)
The need for new drugs is compelling, irrespective of the disease. Focusing on medical problems in the Western countries, heart disease and cancer are at the moment predominant illnesses. Owing to the fact that ~90% of all 21,000 cellular proteins in
Externí odkaz:
https://doaj.org/article/ffe5aa4cc0704227b17fad49fdc4627f
Autor:
Barbara Guerra, Olaf-Georg Issinger
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 139, Iss, Pp 111650-(2021)
Issinger, O-G & Guerra, B 2021, ' Phytochemicals in cancer and their effect on the PI3K/AKT-mediated cellular signalling ', Biomedicine & Pharmacotherapy, vol. 139, 111650 . https://doi.org/10.1016/j.biopha.2021.111650
Issinger, O-G & Guerra, B 2021, ' Phytochemicals in cancer and their effect on the PI3K/AKT-mediated cellular signalling ', Biomedicine & Pharmacotherapy, vol. 139, 111650 . https://doi.org/10.1016/j.biopha.2021.111650
Protein kinases belong to the largest family of enzymes controlling every aspect of cellular activity including gene expression, cell division, differentiation and metabolism. They are part of major intracellular signalling pathways. Hence, it is not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d585b2e2d876a99c575784e976461ee
http://www.sciencedirect.com/science/article/pii/S0753332221004327
http://www.sciencedirect.com/science/article/pii/S0753332221004327
Autor:
Olaf-Georg Issinger, Lars Folke Olsen, Jennifer Hochscherf, Mai Bay Stie, Barbara Guerra, Henrik Seir Thoke
Publikováno v:
Stie, M B, Thoke, H S, Issinger, O-G, Hochscherf, J, Guerra, B & Olsen, L F 2019, ' Delivery of proteins encapsulated in chitosan-tripolyphosphate nanoparticles to human skin melanoma cells ', Colloids and Surfaces B: Biointerfaces, vol. 174, pp. 216-223 . https://doi.org/10.1016/j.colsurfb.2018.11.005
Stie, M B, Thoke, H S, Issinger, O G, Hochscherf, J, Guerra, B & Olsen, L F 2019, ' Delivery of proteins encapsulated in chitosan-tripolyphosphate nanoparticles to human skin melanoma cells ', Colloids and Surfaces B: Biointerfaces, vol. 174, pp. 216-223 . https://doi.org/10.1016/j.colsurfb.2018.11.005
Stie, M B, Thoke, H S, Issinger, O G, Hochscherf, J, Guerra, B & Olsen, L F 2019, ' Delivery of proteins encapsulated in chitosan-tripolyphosphate nanoparticles to human skin melanoma cells ', Colloids and Surfaces B: Biointerfaces, vol. 174, pp. 216-223 . https://doi.org/10.1016/j.colsurfb.2018.11.005
We have successfully encapsulated two proteins, bovine serum albumin (BSA) and p53, in chitosan-tripolyphosphate (TPP) nanoparticles at various pH values from 5.5 to 6.5 and delivered the particles to human melanoma cells. The particles have diameter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993025f1780c6966f9c519f511b96070
https://findresearcher.sdu.dk:8443/ws/files/145485847/Delivery_of_proteins_encapsulated_in_chitosan_tripolyphosphate_nanoparticles_to_human_skin_melanoma_cells.pdf
https://findresearcher.sdu.dk:8443/ws/files/145485847/Delivery_of_proteins_encapsulated_in_chitosan_tripolyphosphate_nanoparticles_to_human_skin_melanoma_cells.pdf
Autor:
Aida Oliván-Viguera, Minne Line Nedergaard Mikkelsen, Niels Marcussen, Olaf-Georg Issinger, Barbara Guerra, Maj Rabjerg, Ralf Köhler
Publikováno v:
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Scopus-Elsevier
Oncotarget
Rabjerg, M, Guerra, B, Oliván-Viguera, A, Mikkelsen, M L N, Köhler, R, Issinger, O G & Marcussen, N 2017, ' Nuclear localization of the CK2α-subunit correlates with poor prognosis in Clear Cell Renal Cell Carcinoma ', Oncotarget, vol. 8, no. 1, pp. 1613-1627 . https://doi.org/10.18632/oncotarget.13693
instname
Scopus-Elsevier
Oncotarget
Rabjerg, M, Guerra, B, Oliván-Viguera, A, Mikkelsen, M L N, Köhler, R, Issinger, O G & Marcussen, N 2017, ' Nuclear localization of the CK2α-subunit correlates with poor prognosis in Clear Cell Renal Cell Carcinoma ', Oncotarget, vol. 8, no. 1, pp. 1613-1627 . https://doi.org/10.18632/oncotarget.13693
// Maj Rabjerg 1 , Barbara Guerra 2 , Aida Olivan-Viguera 3 , Minne Line Nedergaard Mikkelsen 1 , Ralf Kohler 3 , Olaf-Georg Issinger 2 , Niels Marcussen 1 1 Department of Pathology, Odense University Hospital, DK-5000 Odense, Denmark 2 Department of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15838774a213a8d184dcff9ff8745337
https://doi.org/10.18632/oncotarget.13693
https://doi.org/10.18632/oncotarget.13693
Autor:
Naomi X.Y. Ling, Richard C. Foitzik, Bruce E. Kemp, Christopher G. Langendorf, Jonathan S. Oakhill, Olaf-Georg Issinger, John W. Scott
Publikováno v:
Scott, J W, Oakhill, J, Ling, N X Y, Langendorf, C G, Foitzik, R C, Kemp, B E & Issinger, O-G 2014, ' ATP sensitive bi-quinoline activator of the AMP-activated protein kinase ', Biochemical and Biophysical Research Communications, vol. 443, no. 2, pp. 435-440 . https://doi.org/10.1016/j.bbrc.2013.11.130
The AMP-activated protein kinase (AMPK) regulates cellular and whole-body energy balance in response to changes in adenylate charge and hormonal signals. Activation of AMPK in tissues such as skeletal muscle and liver reverses many of the metabolic d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43dd40fd7eb1880b3fb71398546cb31f
https://doi.org/10.1016/j.bbrc.2013.11.130
https://doi.org/10.1016/j.bbrc.2013.11.130
Protein kinase CK2 (formerly casein kinase II or 2) is known to play a critical role in the control of cell growth and cell death and is thus intimately involved in the development of cancer. More specifically, CK2 has been found to be elevated in al
Autor:
Jan Stenvang, Christina Westmose Yde, Mads Gyrd-Hansen, Anne E. Lykkesfeldt, Olaf-Georg Issinger
Publikováno v:
Yde, C W, Gyrd-Hansen, M, Lykkesfeldt, A E, Issinger, O-G & Stenvang, J 2007, ' Breast cancer cells with acquired antiestrogen resistance are sensitized to cisplatin-induced cell death ', Molecular Cancer Therapeutics, vol. 6, no. 6, pp. 1869-1876 . https://doi.org/10.1158/1535-7163.MCT-07-0072
Antiestrogens are currently used for treating breast cancer patients who have estrogen receptor–positive tumors. However, patients with advanced disease will eventually develop resistance to the drugs. Therefore, compounds effective on antiestrogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ae2bf0f0bd9a281b217069c66bca10
https://ora.ox.ac.uk/objects/uuid:b122a432-14c3-4c12-b0ab-ce409ea54357
https://ora.ox.ac.uk/objects/uuid:b122a432-14c3-4c12-b0ab-ce409ea54357