Zobrazeno 1 - 10
of 491
pro vyhledávání: '"Olaf Stüve"'
Autor:
Navid Manouchehri, Olaf Stüve
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 14 (2021)
Externí odkaz:
https://doaj.org/article/101d4de7341f4345b19fc307482ff709
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
While the contribution of autoreactive CD4+ T cells to the pathogenesis of Multiple Sclerosis (MS) is widely accepted, the advent of B cell-depleting monoclonal antibody (mAb) therapies has shed new light on the complex cellular mechanisms underlying
Externí odkaz:
https://doaj.org/article/578f0493bc9a415ab441b2b5e23ce457
Autor:
Darin T. Okuda, Orhun Kantarci, Christine Lebrun‐Frénay, Maria Pia Sormani, Christina J. Azevedo, Francesca Bovis, Le H. Hua, Lilyana Amezcua, Ellen M. Mowry, Christophe Hotermans, Jason Mendoza, John S. Walsh, Christian von Hehn, Wendy S. Vargas, Stacy Donlon, Robert T. Naismith, Annette Okai, Gabriel Pardo, Pavle Repovic, Olaf Stüve, Aksel Siva, Daniel Pelletier
Publikováno v:
Annals of Neurology. 93:604-614
The radiologically isolated syndrome (RIS) represents the earliest detectable pre-clinical phase of multiple sclerosis (MS). This study evaluated the impact of therapeutic intervention in preventing first symptom manifestation at this stage in the di
Autor:
Navid Manouchehri, Yinan Zhang, Amber Salter, Rehana Z. Hussain, Hans-Peter Hartung, Bernhard Hemmer, Ralf Linker, Benjamin M. Segal, Gary Cutter, Olaf Stüve
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 12 (2019)
Clinical trials of new treatments in multiple sclerosis (MS) currently require large sample sizes and long durations in order to yield reliable results. The differential responses of an already heterogeneous population of MS patients to individual di
Externí odkaz:
https://doaj.org/article/7d8a7e1b2ee545328d5244d0d77e1428
Autor:
Kristina Kuhbandner, Anna Hammer, Stefanie Haase, Elisa Terbrack, Alana Hoffmann, Angela Schippers, Norbert Wagner, Rehana Z. Hussain, William A. Miller-Little, Andrew Y. Koh, Joshua S. Stoolman, Benjamin M. Segal, Ralf A. Linker, Olaf Stüve
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Lymphocyte homing into the intestine is mediated by binding of leukocytes to mucosal addressin cell adhesion molecule 1 (MAdCAM-1), expressed on endothelial cells. Currently, the immune system of the gut is considered a major modulator not only of in
Externí odkaz:
https://doaj.org/article/a60a807de7e744a4ba1b34f3b3f64058
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 12 (2019)
Clinical trials have advanced the treatment of multiple sclerosis (MS) by demonstrating the safety and efficacy of disease-modifying therapies (DMTs). This review discusses major changes to MS clinical trials in the era of DMTs. As treatment options
Externí odkaz:
https://doaj.org/article/bc209d7afc304a398c5e82ed4bf092b0
Publikováno v:
Proceedings of the National Academy of Sciences. 120
In the context of autoimmunity, myeloid cells of the central nervous system (CNS) constitute an ontogenically heterogeneous population that includes yolk sac-derived microglia and infiltrating bone marrow-derived cells (BMC). We previously identified
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 11 (2018)
The achievements in multiple sclerosis (MS) therapeutics are founded on the outcomes of clinical trials that demonstrate quantifiable results in treating a disease with an unpredictable course. Much has changed since the early trials in MS from the m
Externí odkaz:
https://doaj.org/article/818bce20919a409a9673d66a5b8a77f3
Publikováno v:
Therapeutic Advances in Neurological Disorders, Vol 11 (2018)
Increasing recognition of the role of B cells in the adaptive immune response makes B cells an important therapeutic target in autoimmunity. Numerous current and developmental immunotherapies target B cells for elimination through recognition of cell
Externí odkaz:
https://doaj.org/article/68a593402a7d4d6c9688390ecdaafa76
Autor:
Petra D Cravens, Rehana Z Hussain, William A Miller-Little, Li-Hong Ben, Benjamin M Segal, Emily Herndon, Olaf Stüve
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0165248 (2016)
Interleukin (IL)-12 and IL-23 are heterodimers that share the p40 subunit, and both cytokines are critical in the differentiation of T helper (Th)1 and Th17 cells, respectively. Th1 and Th17 effector cells have been implicated in the pathogenesis of
Externí odkaz:
https://doaj.org/article/bf8dd2078cc148ea9e9bf73ab97c9381