Zobrazeno 1 - 10
of 325
pro vyhledávání: '"Olaf Schneewind"'
Autor:
Emily Cullum, Yunys Perez-Betancourt, Miaomiao Shi, Eirinaios Gkika, Olaf Schneewind, Dominique Missiakas, Tatyana Golovkina
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1012306 (2024)
Staphylococcus aureus is a human-adapted pathogen that replicates by asymptomatically colonizing its host. S. aureus is also the causative agent of purulent skin and soft tissue infections as well as bloodstream infections that result in the metastat
Externí odkaz:
https://doaj.org/article/8d2a16f647b0419ebcc1b4dbec2dfe4e
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Septal membranes of Staphylococcus aureus serve as the site of secretion for precursors endowed with the YSIRK motif. Depletion of ltaS, a gene required for lipoteichoic acid (LTA) synthesis, results in the loss of restricted trafficking of
Externí odkaz:
https://doaj.org/article/f25b9edb652e4fb5a4c253cecf221b42
Autor:
Natalia Malachowa, Will McGuinness, Scott D. Kobayashi, Adeline R. Porter, Carl Shaia, Jamie Lovaglio, Brian Smith, Viktoria Rungelrath, Greg Saturday, Dana P. Scott, Fabiana Falugi, Dominique Missiakas, Olaf Schneewind, Frank R. DeLeo
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 2 (2022)
ABSTRACT Staphylococcus aureus remains a leading cause of skin and soft tissue infections (SSTIs) globally. In the United States, many of these infections are caused by isolates classified as USA300. Our understanding of the success of USA300 as a hu
Externí odkaz:
https://doaj.org/article/3bd61d6df61c4ce5a25836c22438198e
Autor:
Stefano Mancini, Frank Oechslin, Carmen Menzi, Yok Ai Que, Jorien Claes, Ruth Heying, Tiago Rafael Veloso, Thomas Vanassche, Dominique Missiakas, Olaf Schneewind, Philippe Moreillon, José Manuel Entenza
Publikováno v:
Virulence, Vol 9, Iss 1, Pp 1615-1624 (2018)
Staphylococcus aureus is the leading cause of infective endocarditis (IE). While the role of S. aureus cell-wall associated protein clumping factor A (ClfA) in promoting IE has been already demonstrated, that of the secreted plasma-clotting factors s
Externí odkaz:
https://doaj.org/article/4855cec5dec8479c8dacaf25c336331b
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
ABSTRACT Staphylococcus aureus causes reiterative and chronic persistent infections. This can be explained by the formidable ability of this pathogen to escape immune surveillance mechanisms. Cells of S. aureus display the abundant staphylococcal pro
Externí odkaz:
https://doaj.org/article/9f372872ce4e488c95860d2f26c772c0
Autor:
Manli Na, Zhicheng Hu, Majd Mohammad, Mariana do Nascimento Stroparo, Abukar Ali, Ying Fei, Anders Jarneborn, Peter Verhamme, Olaf Schneewind, Dominique Missiakas, Tao Jin
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT Septic arthritis, one of the most dangerous joint diseases, is predominantly caused by Staphylococcus aureus. In contrast, coagulase-negative staphylococci are rarely found in septic arthritis. We hypothesize that coagulases released by S. a
Externí odkaz:
https://doaj.org/article/cd913e0415954e00a89e814833bb6a1a
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT Staphylococcus aureus is a deadly pathogen that causes fatal diseases in humans. During infection, S. aureus secretes nuclease (Nuc) and adenosine synthase A (AdsA) to generate cytotoxic deoxyadenosine (dAdo) from neutrophil extracellular tr
Externí odkaz:
https://doaj.org/article/96ced280a7214751a3686edfdb0d8892
Autor:
Lindsay Y Chun, Laura Dolle-Molle, Cindy Bethel, Rose C Dimitroyannis, Blake L Williams, Sidney A Schechet, Seenu M Hariprasad, Dominique Missiakas, Olaf Schneewind, Kathleen G Beavis, Dimitra Skondra
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0227071 (2019)
PurposePrompt clinical diagnosis and initiation of treatment are critical in the management of infectious endophthalmitis. Current methods used to identify causative agents of infectious endophthalmitis are mostly inefficient, owing to suboptimal sen
Externí odkaz:
https://doaj.org/article/60fcb545f2b249d788b1a91ea9b47b00
Septal secretion of protein A in Staphylococcus aureus requires SecA and lipoteichoic acid synthesis
Publikováno v:
eLife, Vol 7 (2018)
Surface proteins of Staphylococcus aureus are secreted across septal membranes for assembly into the bacterial cross-wall. This localized secretion requires the YSIRK/GXXS motif signal peptide, however the mechanisms supporting precursor trafficking
Externí odkaz:
https://doaj.org/article/d47da966554440e5be48c1296523c70b
Autor:
Anthony Mitchell, Christina Tam, Derek Elli, Thomas Charlton, Patrick Osei-Owusu, Farbod Fazlollahi, Kym F. Faull, Olaf Schneewind
Publikováno v:
mBio, Vol 8, Iss 3 (2017)
ABSTRACT Glutathionylation, the formation of reversible mixed disulfides between glutathione and protein cysteine residues, is a posttranslational modification previously observed for intracellular proteins of bacteria. Here we show that Yersinia pes
Externí odkaz:
https://doaj.org/article/454ceb1dc8484d7fba68baeebe5881d0