Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Olaf Ritzeler"'
Autor:
Hai-Yu Hu, Danping Ding-Pfennigdorff, Ngee Han Lim, Joachim Saas, K. Ulrich Wendt, Hideaki Nagase, Marc Nazaré, Carsten Schultz, Oliver Plettenburg, olaf Ritzeler
Publikováno v:
Bioconjugate Chemistry. 26:383-388
Targeted drug-delivery methods are crucial for effective treatment of degenerative joint diseases such as osteoarthritis (OA). Toward this goal, we developed a small multivalent structure as a model drug for the attenuation of cartilage degradation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::125c5bc3ca8ee43a88674bbb725c3dd9
https://doi.org/10.1021/bc500557s
https://doi.org/10.1021/bc500557s
Autor:
Asako Shimoda, Kazunari Akiyoshi, Kazuhiro Aoki, Juri Hayashi, Olaf Ritzeler, Hitoyata Shimokawa, Niroshani S. Soysa, Masud Khan, Neil Alles, Keiichi Ohya
Publikováno v:
Endocrinology. 151:4626-4634
Bone degenerative diseases, including osteoporosis, impair the fine balance between osteoclast bone resorption and osteoblast bone formation. Single-agent therapy for anabolic and anticatabolic effects is attractive as a drug target to ameliorate suc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5aa038342dc8014b32ad847109214e
https://doi.org/10.1210/en.2010-0399
https://doi.org/10.1210/en.2010-0399
Publikováno v:
NeuroReport. 17:1615-1618
In behavioral experiments, inhibition of nuclear factor-kappaB activation by systemic administration of the IkappaB kinase inhibitor S1627 has been shown to attenuate inflammatory and neuropathic pain. Here, we specifically investigated with electrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a9054252b989c7ff8f5a116968415c
https://doi.org/10.1097/01.wnr.0000236867.76347.60
https://doi.org/10.1097/01.wnr.0000236867.76347.60
Autor:
Nicolas Bensel, Olaf Ritzeler, Jean-Louis Reymond, Serge P. Parel, Kurt Schenk, Bruno Therrien
Publikováno v:
European Journal of Organic Chemistry. 2000:1365-1372
Transition state mimicry is one of the most powerful concepts in enzyme inhibitor design and has led to the development of catalytic antibodies. Transition state analogs are compounds with a fixed shape that resemble the geometry and charge distribut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b97d9c34408ff6118bff99e0f8c96906
https://doi.org/10.1002/1099-0690(200004)2000:7<1365::aid-ejoc1365>3.0.co
https://doi.org/10.1002/1099-0690(200004)2000:7<1365::aid-ejoc1365>3.0.co
Publikováno v:
Phosphorus, Sulfur, and Silicon and the Related Elements. 144:243-246
Atropisomerism is shown to be a useful design element for transition state analogs. A hydride transfer reaction between dihydroquinolines and ketones was mimicked using 1-substituted 2-naphthoamide...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5eb7f5e73ce812f34017f58090d99e69
https://doi.org/10.1080/10426509908546227
https://doi.org/10.1080/10426509908546227
Autor:
Lothar Hennig, Matthias Findeisen, Dietrich Müller, Olaf Ritzeler, Guy Lemoine, Jean van Heijenoort, Astrid Markus, Maxime Lampilas, Peter Welzel
Publikováno v:
Tetrahedron. 53:1675-1694
A trisaccharide analogue of moenomycin A, 9a, has been synthesized and has found to be antibiotically inactive. This compound differs from an active compound, 9b, solely by the exchange NHAc→OH in unit C. A binding model for moenomycin-type transgl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bc6156984a9fa7ebfcde525b3cf4ab9
https://doi.org/10.1016/s0040-4020(96)01115-5
https://doi.org/10.1016/s0040-4020(96)01115-5
Autor:
Olaf Ritzeler, Matthias Findeisen, Astrid Markus, Lothar Hennig, G. Lemoine, Maxime Lampilas, Peter Welzel, D. Mueller, J van Heijenoort
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51c747022c6e8ff6b8a69e95459d8ca6
https://doi.org/10.1002/chin.199720225
https://doi.org/10.1002/chin.199720225
Autor:
Jan Torzewski, Olaf Ritzeler, Vinzenz Hombach, Jürgen Dedio, Stefan Schäfer, Frank Kramer, Yuri Ivashchenko, Andreas Busch, Andrea Bucher, Kerstin Veit
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 25(1)
Objective—C-Reactive protein (CRP) is the prototype acute phase protein and a cardiovascular risk factor. Interleukin-1β (IL-1β) and IL-6 stimulate CRP synthesis in hepatocytes. We searched for additional pathways regulating CRP expression.Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6447be336d1c8e1639f8e6b24be1dfd9
https://pubmed.ncbi.nlm.nih.gov/15539624
https://pubmed.ncbi.nlm.nih.gov/15539624
Autor:
Martin Michaelis, Irmgard Tegeder, Hans Gühring, Ronald Schmidt, Susanne Kunz, Olaf Ritzeler, Gerd Geisslinger, Ellen Niederberger
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(7)
Phosphorylation of IκB through IκB kinase (IKK) is the first step in nuclear factor κB (NF-κB) activation and upregulation of NF-κB-responsive genes. Hence, inhibition of IKK activity may be expected to prevent injury-, infection-, or stress-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d489d221849ced9ff179ea0e419855
https://pubmed.ncbi.nlm.nih.gov/14973242
https://pubmed.ncbi.nlm.nih.gov/14973242
Autor:
Neil Alles, Niroshani S. Soysa, Juri Hayashi, Masud Khan, Asako Shimoda, Hitoyata Shimokawa, Olaf Ritzeler, Kazunari Akiyoshi, Kazuhiro Aoki, Keiichi Ohya
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 95:4477-4477
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a60154835b450a8c407bbc6864321574
https://doi.org/10.1210/jcem.95.9.9992
https://doi.org/10.1210/jcem.95.9.9992