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Akademický článek

Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ

Autor: Tamara Göbel, Olaf Diehl, Jan Heering, Daniel Merk, Carlo Angioni, Sandra K. Wittmann, Estel.la Buscato, Ramona Kottke, Lilia Weizel, Tim Schader, Thorsten J. Maier, Gerd Geisslinger, Manfred Schubert-Zsilavecz, Dieter Steinhilber, Ewgenij Proschak, Astrid S. Kahnt

Publikováno v: Frontiers in Pharmacology, Vol 10 (2019)

Cysteinyl leukotriene receptor 1 antagonists (CysLT1RA) are frequently used as add-on medication for the treatment of asthma. Recently, these compounds have shown protective effects in cardiovascular diseases. This prompted us to investigate their in

Externí odkaz: https://doaj.org/article/a80e026f90b747f8b7674c1f676db0f4

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Design and synthesis of fused soluble epoxide hydrolase/peroxisome proliferator-activated receptor modulators

Autor: Daniel Merk, René Blöcher, Olaf Diehl, Sandra K. Wittmann, Ewgenij Proschak, Manfred Schubert-Zsilavecz, Thomas Hanke, Astrid S. Kahnt, Christina Lamers, Dieter Steinhilber

Publikováno v: MedChemComm. 7:1209-1216

Metabolic syndrome (MetS) is a widespread, complex disease cluster which consists of hypertension, atherosclerosis, dyslipidaemia and type II diabetes. The treatment of MetS requires multiple pharmaceutical agents leading to complex polypharmacy. Mul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7fab54bf19237bb858ca099108164499
https://doi.org/10.1039/c6md00042h

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Cysteinyl leukotriene-receptor-1 antagonists interfere with PGE2 synthesis by inhibiting mPGES-1 activity

Autor: Svenja Dorothea Steinbrink, Carlo Angioni, Sabine Grösch, Bettina Hofmann, Thorsten J. Maier, Christoph Lehmann, Gerd Geisslinger, Dieter Steinhilber, Olaf Diehl, Florian Rörsch, Astrid S. Kahnt

Publikováno v: Kahnt, A S, Rörsch, F, Diehl, O, Hofmann, B, Lehmann, C, Steinbrink, S D, Angioni, C, Geisslinger, G, Grösch, S, Steinhilber, D & Maier, T 2013, ' Cysteinyl leukotriene-receptor-1 antagonists interfere with PGE2 synthesis by inhibiting mPGES-1 activity ', Biochemical Pharmacology, vol. 86, no. 2, pp. 286-96 . https://doi.org/10.1016/j.bcp.2013.05.005

Because of their favourable safety profile and beneficial anti-inflammatory properties, the CysLT1 receptor antagonists (LTRA), montelukast, zafirlukast and pranlukast are approved for the treatment of asthma and are frequently prescribed as add-on t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5da89c3cb2ec12cb8089609f2075baa
https://doi.org/10.1016/j.bcp.2013.05.005

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'Disease modifying nutricals' for multiple sclerosis

Autor: Katja Schmitz, Leonie Stolz, Julia Barthelmes, Susanne Beyer, Irmgard Tegeder, Olaf Diehl

Publikováno v: Pharmacologytherapeutics. 148

The association between vitamin D and multiple sclerosis has (re)-opened new interest in nutrition and natural compounds in the prevention and treatment of this neuroinflammatory disease. The dietary amount and type of fat, probiotics and biologicals

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d9894a0157f2c3249f847c8914c587
https://pubmed.ncbi.nlm.nih.gov/25435020

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PREVENTING POST-TREATMENT BACTEREMIA: COMPARING TOPICAL POVIDONE-IODINE AND CHLORHEXIDINE

Autor: Pramod M. Shah, V. Schäfer, Olaf Diehl, R. Rahn, Sabine Schneider

Publikováno v: The Journal of the American Dental Association. 126:1145-1148

It is well known that the occurrence of bacteremia after dental procedures can place certain patients at risk for bacterial endocarditis. The authors compared the efficacy of two antiseptic agents in the prevention of post-treatment bacteremia in 120

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e8f24d2d5f3fa26940df73d09cb689
https://doi.org/10.14219/jada.archive.1995.0334

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