Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Olaf Döhr"'
Autor:
Gerhard Siemeister, Amaury Ernesto Fernandez-Montalvan, Volker K Schulze, Uwe Eberspaecher, Roland Neuhaus, Simon Holton, Stefan Prechtl, Michael Brands, Benjamin Bader, Marian Raschke, Duy Nguyen, Tobias Marquardt, Dirk Kosemund, Detlef Stöckigt, Ulf Bömer, Bertolt Kreft, Hartmut Schirok, Rolf Bohlmann, Antje Margret Wengner, Philip Lienau, Marcus Koppitz, Franz von Nussbaum, Rolf Jautelat, Michael Dr. Brüning, Hans Briem, Dominik Mumberg, Karl Ziegelbauer, Ulrich Klar, Olaf Döhr
Publikováno v:
Journal of Medicinal Chemistry. 63:8025-8042
Inhibition of monopolar spindle 1 (MPS1) kinase represents a novel approach to cancer treatment: instead of arresting the cell cycle in tumor cells, cells are driven into mitosis irrespective of DNA damage and unattached/misattached chromosomes, resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d455cb11862ac96ed455f56494ef1c0a
https://doi.org/10.1021/acs.jmedchem.9b02035
https://doi.org/10.1021/acs.jmedchem.9b02035
Autor:
Olaf Döhr, Christa Hegele-Hartung, Ursula Mönning, Keith Graham, Ralf Lesche, Georg Kettschau, Ludger Dinkelborg, Sandra Borkowski, Alexey Gromov, Niels Böhnke
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 41:89-101
Prostate-specific membrane antigen (PSMA) is a transmembrane protein overexpressed in prostate cancer and is therefore being explored as a biomarker for diagnosing and staging of the disease. Here we report preclinical data on BAY 1075553 (a 9:1 mixt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f67d258fcbcecadb7b3750eac406c38
https://doi.org/10.1007/s00259-013-2527-3
https://doi.org/10.1007/s00259-013-2527-3
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant, which causes a variety of toxic effects including alterations in cell growth and differentiation. In the l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4906281cb6b85b9a01c4a69dfd8f8481
https://doi.org/10.1159/000424205
https://doi.org/10.1159/000424205
Publikováno v:
Proceedings of the National Academy of Sciences. 98:81-86
A functional human NADH-dependent cytochrome P450 system has been developed by altering the cofactor preference of human NADPH cytochrome P450 reductase (CPR), the redox partner for P450s. This has been achieved by a single amino acid change of the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b1a170c2d5a0fdae48bf61a69379bfe
https://doi.org/10.1073/pnas.98.1.81
https://doi.org/10.1073/pnas.98.1.81
Autor:
Olaf Döhr, Josef Abel
Publikováno v:
Biochemical and Biophysical Research Communications. 241:86-91
Transforming growth factor (TGF)-beta1 down-regulates mRNA expression of the aryl hydrocarbon receptor (AhR) and of AhR-inducible genes in A549 cells. Here, we describe a dose-dependent inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8ade457e050b18a7d75a22dceada29
https://doi.org/10.1006/bbrc.1997.7773
https://doi.org/10.1006/bbrc.1997.7773
Publikováno v:
Molecular Pharmacology. 51:703-710
An inhibitory effect on both constitutive and inducible expression of cytochrome P450 isoenzymes has been shown for different cytokines and growth factors. We previously described an inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced CY
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8a54ca7b7a59d7896535d3f2a8e31a6
https://doi.org/10.1124/mol.51.5.703
https://doi.org/10.1124/mol.51.5.703
Publikováno v:
Archives of Biochemistry and Biophysics. 321:405-412
Human breast cancer cell lines are widely used to study the antiestrogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in vitro. Like other groups we found that 10 nM TCDD inhibits cell growth and induces cytochrome P450 1A1 (CYP1A1)-associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c0398321aefcf4e7ba29c38d87853a
https://doi.org/10.1006/abbi.1995.1411
https://doi.org/10.1006/abbi.1995.1411
Publikováno v:
Archives of Toxicology. 68:303-307
The effect of transforming growth factor-beta 1 (TGF-beta 1) on the expression of cytochrome P450IA1 (CYPIA1) was examined in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-treated human lung cancer A549 cells. Using the reverse transcription-polymerase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fcfaaff95ea8912b2197c2c8aae2a7e
https://doi.org/10.1007/s002040050073
https://doi.org/10.1007/s002040050073
Publikováno v:
Investigative radiology. 42(12)
Objectives Gadoxetic acid [gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA); Primovist] is a liver specific contrast agent for magnetic resonance imaging. For risk assessment of the single diagnostic use the toxicity of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4862afa4f90acbb8343752aab2cdff09
https://pubmed.ncbi.nlm.nih.gov/18007155
https://pubmed.ncbi.nlm.nih.gov/18007155
Publikováno v:
Archives of toxicology. 74(3)
Primary hepatocytes are a widely used cell model to analyse the expression and regulation of hepatic cytochrome P450 (CYP) isoenzymes. Transforming growth factor-beta1 (TGF-beta1) was previously shown to inhibit constitutive and induced CYP1 expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4b0b152f81971b3b79c6fc4493f80fe
https://pubmed.ncbi.nlm.nih.gov/10877000
https://pubmed.ncbi.nlm.nih.gov/10877000