Výsledky vyhledávání - "Olaf Brouwers"

Akademický článek

Mild Oxidative Damage in the Diabetic Rat Heart Is Attenuated by Glyoxalase-1 Overexpression

Autor: Casper G. Schalkwijk, Coen D. A. Stehouwer, Geja Hageman, Ben J. A. Janssen, Frans van Nieuwenhoven, Toshio Miyata, Joyce M. J. de Vos-Houben, Petra M. G. Niessen, Olaf Brouwers

Publikováno v: International Journal of Molecular Sciences, Vol 14, Iss 8, Pp 15724-15739 (2013)

Diabetes significantly increases the risk of heart failure. The increase in advanced glycation endproducts (AGEs) and oxidative stress have been associated with diabetic cardiomyopathy. We recently demonstrated that there is a direct link between AGE

Externí odkaz: https://doaj.org/article/ceb6ef4724a847b88ccf4d6b59408122

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Akademický článek

Hypertension is a conditional factor for the development of cardiac hypertrophy in type 2 diabetic mice.

Autor: Marc van Bilsen, Anneleen Daniels, Olaf Brouwers, Ben J A Janssen, Wouter J A Derks, Agnieszka E Brouns, Chantal Munts, Casper G Schalkwijk, Ger J van der Vusse, Frans A van Nieuwenhoven

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e85078 (2014)

BACKGROUND: Type 2 diabetes is frequently associated with co-morbidities, including hypertension. Here we investigated if hypertension is a critical factor in myocardial remodeling and the development of cardiac dysfunction in type 2 diabetic db/db m

Externí odkaz: https://doaj.org/article/0971133d3b4e4f369d73c74685f0d613

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Glyoxalase-1 overexpression partially prevents diabetes-induced impaired arteriogenesis in a rat hindlimb ligation model

Autor: Toshio Miyata, Maya S. P. Huijberts, Petra Niessen, Mark J. Post, Liang Yu, Olaf Brouwers, Casper G. Schalkwijk, Jos Slenter, Allard Wagenaar, Walter H. Backes, Karolien Jaspers, Coen D.A. Stehouwer

Publikováno v: Glycoconjugate Journal, 33(4), 627-630. Springer
Glycoconjugate Journal

We hypothesize that diabetes-induced impaired collateral formation after a hindlimb ligation in rats is in part caused by intracellular glycation and that overexpression of glyoxalase-I (GLO-I), i.e. the major detoxifying enzyme for advanced-glycatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a8f49cd82329dd67bfc601afb71de3
https://doi.org/10.1007/s10719-016-9681-3

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Delayed Intervention With Pyridoxamine Improves Metabolic Function and Prevents Adipose Tissue Inflammation and Insulin Resistance in High-Fat Diet–Induced Obese Mice

Autor: Ben J. A. Janssen, Coen D.A. Stehouwer, Olaf Brouwers, Katrien H.J. Gaens, Kristiaan Wouters, Casper G. Schalkwijk, Toshio Miyata, Jack P.M. Cleutjens, Dionne E. Maessen

Publikováno v: Diabetes, 65(4), 956-966. American Diabetes Association

Obesity is associated with an increased risk for the development of type 2 diabetes and vascular complications. Advanced glycation end products are increased in adipose tissue and have been associated with insulin resistance, vascular dysfunction, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea215cb1573086c7a12daf254d0f18a
https://doi.org/10.2337/db15-1390

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Glyoxalase 1 overexpression does not affect atherosclerotic lesion size and severity in ApoE(-/-) mice with or without diabetes

Autor: Jack P.M. Cleutjens, Erwin Wijnands, Marion J.J. Gijbels, Jo G. R. De Mey, Erik A.L. Biessen, Kristiaan Wouters, Toshio Miyata, Olaf Brouwers, Coen D.A. Stehouwer, Casper G. Schalkwijk, Nordin M J Hanssen

Publikováno v: Cardiovascular Research, 104(1), 160-170. Oxford University Press
Cardiovascular research, 104(1), 160-170. Oxford University Press
Hanssen, N M J, Brouwers, O, Gijbels, M J, Wouters, K, Wijnands, E, Cleutjens, J P M, De Mey, J G, Miyata, T, Biessen, E A, Stehouwer, C D A & Schalkwijk, C G 2014, ' Glyoxalase 1 overexpression does not affect atherosclerotic lesion size and severity in ApoE-/-mice with or without diabetes ', Cardiovascular Research, vol. 104, no. 1, pp. 160-170 . https://doi.org/10.1093/cvr/cvu189

AIMS: Advanced glycation end-products (AGEs) and their precursors have been associated with the development of atherosclerosis. We recently discovered that glyoxalase 1 (GLO1), the major detoxifying enzyme for AGE precursors, is decreased in ruptured

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d06d9f40622543323ab73aec14ba02
https://cris.maastrichtuniversity.nl/en/publications/172193de-7599-40a7-88ee-f3237dbc8b89

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Overexpression of Glyoxalase-I Reduces Hyperglycemia-induced Levels of Advanced Glycation End Products and Oxidative Stress in Diabetic Rats

Autor: Olaf Brouwers, Tom Teerlink, Toshio Miyata, Petra Niessen, Peter G. Scheffer, Casper G. Schalkwijk, Michael Brownlee, Coen D.A. Stehouwer, Isabel Ferreira, Patrick Schrauwen

Publikováno v: Journal of Biological Chemistry, 286(2), 1374-1380. American Society for Biochemistry and Molecular Biology Inc.
Journal of Biological Chemistry, 286(2), 1374-1380. American Society for Biochemistry and Molecular Biology, Inc.
Brouwers, O, Niessen, P M, Ferreira, I, Miyata, T, Scheffer, P G, Teerlink, T, Schrauwen, P, Brownlee, M, Stehouwer, C D A & Schalkwijk, C G 2011, ' Overexpression of Glyoxalase-I Reduces Hyperglycemia-induced Levels of Advanced Glycation End Products and Oxidative Stress in Diabetic Rats ', Journal of Biological Chemistry, vol. 286, no. 2, pp. 1374-1380 . https://doi.org/10.1074/jbc.M110.144097

The reactive advanced glycation end product (AGE) precursor methylglyoxal (MGO) and MGO-derived AGEs are associated with diabetic vascular complications and also with an increase in oxidative stress. Glyoxalase-I (GLO-I) transgenic rats were used to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9913ae595f6a196b30f4aa1569d367
https://doi.org/10.1074/jbc.M110.144097

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Polymorphisms in glyoxalase 1 gene are not associated with vascular complications: the Hoorn and CoDAM studies

Autor: Giel Nijpels, Carla J.H. van der Kallen, Ellen E. Blaak, L. Engelen, Olaf Brouwers, Ronald M.A. Henry, Robert J. Heine, Marleen M.J. van Greevenbroek, Casper G. Schalkwijk, Hugo ten Cate, Edith J. M. Feskens, Coen D.A. Stehouwer, Isabel Ferreira, Jacqueline M. Dekker

Publikováno v: Journal of Hypertension 27 (2009) 7
Journal of Hypertension, 27(7), 1399-1403
Engelen, L, Ferreira, I, Brouwers, O, Henry, R M A, Dekker, J M, Nijpels, M G A A M, Heine, R J, van Greevenbroek, M M J, van der Kallen, C J H, Blaak, E E, Feskens, E J M, Ten Cate, H, Stehouwer, C D A & Schalkwijk, C 2009, ' Polymorphisms in glyoxalase 1 gene are not associated with vascular complications: the Hoorn and CoDAM studies ', Journal of Hypertension, vol. 27, no. 7, pp. 1399-1403 . https://doi.org/10.1097/HJH.0b013e32832af6ba
Journal of Hypertension, 27(7), 1399-1403. Lippincott Williams and Wilkins

OBJECTIVES: Methylglyoxal is a major precursor in the formation of advanced glycation endproducts (AGEs), which are known to contribute to vascular complications such as hypertension and arterial stiffness. Methylglyoxal can be detoxified by glyoxala

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b05a9f5bece2d8e9bd882890ee791d
https://hdl.handle.net/1871/27880

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PS1 - 6. Pyridoxamine improves adiposity and insulin resistance in high-fed diet induced obese mice

Autor: Coen D.A. Stehouwer, Olaf Brouwers, Katrien H.J. Gaens, Toshio Miyata, Casper G. Schalkwijk

Publikováno v: Nederlands Tijdschrift voor Diabetologie. 11:145-146

Obesity is characterized by a dysregulation of pro- and anti-inflammatory adipokines which are involved in the pathogenesis of obesity-related insulin resistance and type 2 diabetes. We showed that the advanced glycation endproduct (AGE), Ne-(Carboxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8e41d171db6f5303ccee5e8f3d5431f9
https://doi.org/10.1007/s12467-013-0084-9

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