Zobrazeno 1 - 10
of 425
pro vyhledávání: '"Olaf Wolkenhauer"'
Autor:
Saurabh Singh, Sarika Yadav, Celine Cavallo, Durgesh Mourya, Ishu Singh, Vijay Kumar, Sachin Shukla, Pallavi Shukla, Romil Chaudhary, Gyan Prakash Maurya, Ronja Lea Jennifer Müller, Lilly Rohde, Aradhana Mishra, Olaf Wolkenhauer, Shailendra Gupta, Anurag Tripathi
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract Skin cancer and other skin-related inflammatory pathologies are rising due to heightened exposure to environmental pollutants and carcinogens. In this context, natural products and repurposed compounds hold promise as novel therapeutic and p
Externí odkaz:
https://doaj.org/article/9aaffdfee7284b17ad4eb915e7ed26ce
Autor:
Carola Berking, Gerold Schuler, Olaf Wolkenhauer, Annelies W Turksma, Heiko Bruns, Julio Vera, Martin Eberhardt, Manuel Wiesinger, Beatrice Schuler-Thurner, Cindy Flamann, Markus Vincent Heppt, Shailendra Gupta, Christopher Lischer, Johannes Berges, Esther Güse, Anja Wessely, Adrian Weich, Jimmy Retzlaff, Jan Dörrie, Niels Schaft, Johannes März, Harald Knorr, Krishna Pal Singh, Elias Andreas Thomas Koch, Nadine D van Kleef, Julian J Freen-van Heeren, Bettina Hohberger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 5 (2024)
Background Tumor-associated antigens and their derived peptides constitute an opportunity to design off-the-shelf mainline or adjuvant anti-cancer immunotherapies for a broad array of patients. A performant and rational antigen selection pipeline wou
Externí odkaz:
https://doaj.org/article/f5b73ac9110f43bf9d82c89934e31442
Autor:
Nivedita Singh, Faiz M Khan, Lakshmi Bala, Julio Vera, Olaf Wolkenhauer, Brigitte Pützer, Stella Logotheti, Shailendra K. Gupta
Publikováno v:
BMC Chemistry, Vol 17, Iss 1, Pp 1-20 (2023)
Abstract Melanoma presents increasing prevalence and poor outcomes. Progression to aggressive stages is characterized by overexpression of the transcription factor E2F1 and activation of downstream prometastatic gene regulatory networks (GRNs). Appro
Externí odkaz:
https://doaj.org/article/53a7ebe4e78a44ae85ff7ce82585f5bf
Autor:
Anna Niarakis, Marek Ostaszewski, Alexander Mazein, Inna Kuperstein, Martina Kutmon, Marc E. Gillespie, Akira Funahashi, Marcio Luis Acencio, Ahmed Hemedan, Michael Aichem, Karsten Klein, Tobias Czauderna, Felicia Burtscher, Takahiro G. Yamada, Yusuke Hiki, Noriko F. Hiroi, Finterly Hu, Nhung Pham, Friederike Ehrhart, Egon L. Willighagen, Alberto Valdeolivas, Aurelien Dugourd, Francesco Messina, Marina Esteban-Medina, Maria Peña-Chilet, Kinza Rian, Sylvain Soliman, Sara Sadat Aghamiri, Bhanwar Lal Puniya, Aurélien Naldi, Tomáš Helikar, Vidisha Singh, Marco Fariñas Fernández, Viviam Bermudez, Eirini Tsirvouli, Arnau Montagud, Vincent Noël, Miguel Ponce-de-Leon, Dieter Maier, Angela Bauch, Benjamin M. Gyori, John A. Bachman, Augustin Luna, Janet Piñero, Laura I. Furlong, Irina Balaur, Adrien Rougny, Yohan Jarosz, Rupert W. Overall, Robert Phair, Livia Perfetto, Lisa Matthews, Devasahayam Arokia Balaya Rex, Marija Orlic-Milacic, Luis Cristobal Monraz Gomez, Bertrand De Meulder, Jean Marie Ravel, Bijay Jassal, Venkata Satagopam, Guanming Wu, Martin Golebiewski, Piotr Gawron, Laurence Calzone, Jacques S. Beckmann, Chris T. Evelo, Peter D’Eustachio, Falk Schreiber, Julio Saez-Rodriguez, Joaquin Dopazo, Martin Kuiper, Alfonso Valencia, Olaf Wolkenhauer, Hiroaki Kitano, Emmanuel Barillot, Charles Auffray, Rudi Balling, Reinhard Schneider, the COVID-19 Disease Map Community
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionThe COVID-19 Disease Map project is a large-scale community effort uniting 277 scientists from 130 Institutions around the globe. We use high-quality, mechanistic content describing SARS-CoV-2-host interactions and develop interoperable b
Externí odkaz:
https://doaj.org/article/ac53015acf3143cf9c3f232ae67ad161
Autor:
Eike Matthias Wacker, Florian Uellendahl-Werth, Saptarshi Bej, Olaf Wolkenhauer, Mette Vesterhus, Wolfgang Lieb, Andre Franke, Tom Hemming Karlsen, Trine Folseraas, David Ellinghaus
Publikováno v:
JHEP Reports, Vol 6, Iss 2, Pp 100988- (2024)
Background & Aims: Genetic and microbiome studies across patients with primary sclerosing cholangitis (PSC) and ulcerative colitis (UC) have indicated that UC in PSC is a separate disease entity to primary UC, but expression studies for PSC are lacki
Externí odkaz:
https://doaj.org/article/e621b389973f46bcb8be965ca0328d62
Autor:
Praveen Vasudevan, Markus Wolfien, Heiko Lemcke, Cajetan Immanuel Lang, Anna Skorska, Ralf Gaebel, Anne-Marie Galow, Dirk Koczan, Tobias Lindner, Wendy Bergmann, Brigitte Mueller-Hilke, Brigitte Vollmar, Bernd Joachim Krause, Olaf Wolkenhauer, Gustav Steinhoff, Robert David
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-18 (2023)
Abstract Background The immune response is a crucial factor for mediating the benefit of cardiac cell therapies. Our previous research showed that cardiomyocyte transplantation alters the cardiac immune response and, when combined with short-term pha
Externí odkaz:
https://doaj.org/article/c1342d67edd547f692361732bde8fead
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-9 (2023)
Abstract Genome-scale metabolic models (GEMs) are extensively used to simulate cell metabolism and predict cell phenotypes. GEMs can also be tailored to generate context-specific GEMs, using omics data integration approaches. To date, many integratio
Externí odkaz:
https://doaj.org/article/d4a4b7efb7db4e919ada75208aca142d
Autor:
Saptarshi Bej, Chaithra Umesh, Manjunath Mahendra, Kristian Schultz, Jit Sarkar, Olaf Wolkenhauer
Publikováno v:
Machine Learning with Applications, Vol 14, Iss , Pp 100490- (2023)
Tabular Clinical and Biomedical Routine Data (CBRD) contains diverse feature types. Recent research shows that the conventional application of Uniform Manifold Projection and Approximation (UMAP) to extract clusters from the low dimensional embedding
Externí odkaz:
https://doaj.org/article/174bd4fbd7324939a2b05967ee5e3b1e
Autor:
Matti Hoch, Suchi Smita, Konstantin Cesnulevicius, Myron Schultz, David Lescheid, Olaf Wolkenhauer, Shailendra Gupta
Publikováno v:
Journal of Inflammation, Vol 20, Iss 1, Pp 1-15 (2023)
Abstract Background Modifying the acute inflammatory response has wide clinical benefits. Current options include non-steroidal anti-inflammatory drugs (NSAIDs) and therapies that may resolve inflammation. Acute inflammation involves multiple cell ty
Externí odkaz:
https://doaj.org/article/b349f87666904668b9d0eba218cbb092
Publikováno v:
MGM Journal of Medical Sciences, Vol 10, Iss 4, Pp 610-620 (2023)
Background: The present study aimed to identify biomarker genes associated with disease progression from an early and advanced stage to metastatic oral squamous cell carcinoma (OSCC) and to explore their regulatory mechanism. Materials and Methods: T
Externí odkaz:
https://doaj.org/article/f8b33fa6f055405fb8239b758fbe95b5