Výsledky vyhledávání - "Olaf, Thuerigen"

Development of encorafenib for BRAF-mutated advanced melanoma

Autor: Peter Koelblinger, Reinhard Dummer, Olaf Thuerigen

Publikováno v: Current Opinion in Oncology

Purpose of review To describe the pharmacological properties, preclinical and clinical data of the novel V-Raf Murine Sarcoma Viral Oncogene Homolog B (BRAF)-inhibitor encorafenib (LGX818) and to compare these with established BRAF-inhibitors in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec895c4b6dda3be3c3b4cfdf19204fb
https://doi.org/10.5167/uzh-149821

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The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma

Autor: Stefan, Pfister, Stephen, Rea, Mikko, Taipale, Frank, Mendrzyk, Beate, Straub, Carina, Ittrich, Olaf, Thuerigen, Hans Peter, Sinn, Asifa, Akhtar, Peter, Lichter

Publikováno v: International journal of cancer. 122(6)

Loss of H4 lysine 16 (H4K16) acetylation was shown to be a common feature in human cancer. However, it remained unclear which enzyme is responsible for the loss of this modification. Having recently identified the histone acetyltransferase human MOF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1be8e2351251d2bb556aded81e7b4ca3
https://pubmed.ncbi.nlm.nih.gov/18058815

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Gene expression signature predicting pathologic complete response with gemcitabine, epirubicin, and docetaxel in primary breast cancer

Autor: Christof Sohn, Heidi Kramer, Benedikt Brors, Bjoern Tews, Florian Schuetz, Axel Benner, Christian Rudlowski, Olaf Thuerigen, Meinhard Hahn, Roland Eils, Andreas Schneeweiss, Grischa Toedt, Peter Lichter, Patrick Warnat, Hans-Peter Sinn

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 24(12)

Purpose Primary systemic therapy (PST) with gemcitabine (G), epirubicin (E), and docetaxel (Doc) has resulted in a pathologic complete response (pCR) in 26% of primary breast cancer patients. This study was aimed at the identification of a gene expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578b272d6db0b9bc700da56eff635713
https://pubmed.ncbi.nlm.nih.gov/16622258

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Gene expression profiles predict pathologic complete response to preoperative chemotherapy with gemcitabine, epirubicin and docetaxel in primary breast cancer

Autor: Olaf Thuerigen, Benedikt Brors, Andreas Schneeweiss, Christian Rudlowski, Patrick Warnat, Peter Lichter, Meinhard Hahn, Grischa Toedt, Axel Benner, Christof Sohn

Publikováno v: Journal of Clinical Oncology. 23:2001-2001

2001 Background: While primary systemic therapy (PST) has gained considerable attention, it is impossible to predict sensitivity of primary breast cancer (PBC) to specific drugs. This study was designed to discover a gene expression profile that pred

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ed60e5cf8ff927204841882c8ec8d56
https://doi.org/10.1200/jco.2005.23.16_suppl.2001

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Effective transcriptome amplification for expression profiling on sense-oriented oligonucleotide microarrays

Autor: Peter Lichter, Olaf Thuerigen, Joerg Schlingemann, Heidi Kramer, Grischa Toedt, Carina Ittrich, Meinhard Hahn

Publikováno v: Nucleic Acids Research

Gene expression analysis using microarrays of synthetic long oligonucleotides is limited in that it requires substantial amounts of RNA. To obtain these quantities from minute amounts of starting material, protocols were developed that linearly ampli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b0f90b01ce8109094c44ca89bea804
http://europepmc.org/articles/PMC549428

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