Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Olaf, Ninnemann"'
Autor:
Sylvie Picker-Minh, Ilaria Luperi, Ethiraj Ravindran, Nadine Kraemer, Sami Zaqout, Gisela Stoltenburg-Didinger, Olaf Ninnemann, Luis R. Hernandez-Miranda, Shyamala Mani, Angela M. Kaindl
Publikováno v:
The Cerebellum.
Hom ozygous variants in the peptidyl-tRNA hydrolase 2 gene (PTRH2) cause infantile-onset multisystem neurologic, endocrine, and pancreatic disease. The objective is to delineate the mechanisms underlying the core cerebellar phenotype in this disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cefd16a577efc7dea775800c7c8235e5
https://doi.org/10.1007/s12311-022-01488-z
https://doi.org/10.1007/s12311-022-01488-z
Autor:
Ethiraj Ravindran, Hao Hu, Scott A Yuzwa, Luis R Hernandez-Miranda, Nadine Kraemer, Olaf Ninnemann, Luciana Musante, Eugen Boltshauser, Detlev Schindler, Angela Hübner, Hans-Christian Reinecker, Hans-Hilger Ropers, Carmen Birchmeier, Freda D Miller, Thomas F Wienker, Christoph Hübner, Angela M Kaindl
Publikováno v:
PLoS Genetics, Vol 13, Iss 4, p e1006746 (2017)
Mid-hindbrain malformations can occur during embryogenesis through a disturbance of transient and localized gene expression patterns within these distinct brain structures. Rho guanine nucleotide exchange factor (ARHGEF) family members are key for co
Externí odkaz:
https://doaj.org/article/5b284e26306f4ccab2416e2e9381e227
Autor:
Nadine Kraemer, Lina Issa-Jahns, Gerda Neubert, Ethiraj Ravindran, Shyamala Mani, Olaf Ninnemann, Angela M Kaindl
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0136684 (2015)
Autosomal recessive primary microcephaly (MCPH) is a rare neurodevelopmental disorder characterized by a pronounced reduction of brain volume and intellectual disability. A current model for the microcephaly phenotype invokes a stem cell proliferatio
Externí odkaz:
https://doaj.org/article/77601ca3df8b415280757c17314ab930
Autor:
Jisen Huai, Roger A. Sabbadini, Heiko Endle, Zoltán Molnár, Robert Nitsch, Jin Cheng, Olaf Ninnemann, Hans Michael Maric, Albrecht Stroh, Sadhna Sahani, Torben J. Hausrat, Heiko J. Luhmann, Jenq-Wei Yang, Pierre-Hugues Prouvot, Xinfeng Liu, Barbara Visentin, Matthias Kneussel, Thorsten Trimbuch, Nikolai Schmarowski, Wei Fan, Konstantin Radyushkin, Haichao Ji, Kristian Strømgaard, Yunbo Li, Rahel Böttche, Anna Hoerder-Suabedissen, Johannes Vogt
Publikováno v:
Neuron
Summary Precise connection of thalamic barreloids with their corresponding cortical barrels is critical for processing of vibrissal sensory information. Here, we show that PRG-2, a phospholipid-interacting molecule, is important for thalamocortical a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663c20cb2aae7ed8aa2abc2c76dbee8e
http://europepmc.org/articles/PMC5065528
http://europepmc.org/articles/PMC5065528
Publikováno v:
Neurological Research. 34:664-668
Gene expression analysis via quantitative real-time PCR (qPCR) is a key approach in biological and medical research. Here, variations between runs and samples are compensated for by in-parallel analysis of reference genes, which require a most stable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb7d2ddc895fcdb13091ac76a7ab359
https://doi.org/10.1179/1743132812y.0000000060
https://doi.org/10.1179/1743132812y.0000000060
Autor:
Douglas T. Golenbock, Seija Lehnardt, Michael Hinz, F. Gregory Wulczyn, Oliver Peters, David Kaul, Boyoun Park, Jan Baumgart, Agnieszka Rybak, Eleonora Franzoni, Eckart Schott, Thorsten Trimbuch, Katja Derkow, Duong T. T. Nguyen, Frank L. Heppner, Christina Krüger, Hidde L. Ploegh, Robert Nitsch, Gina D. Eom, Rüdiger W. Veh, Roland E. Kälin, Olaf Ninnemann, Piet Habbel, Sabrina M. Lehmann, Karen Rosenberger
Publikováno v:
Nature Neuroscience. 15:827-835
Activation of innate immune receptors by host-derived factors exacerbates CNS damage, but the identity of these factors remains elusive. We uncovered an unconventional role for the microRNA let-7, a highly abundant regulator of gene expression in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d5ac9682bcbaa883e5cec0b90097ef
https://doi.org/10.1038/nn.3113
https://doi.org/10.1038/nn.3113
Autor:
Nadine Kraemer, Shyamala Mani, Angela M. Kaindl, Stefanie C. R. Hauck, Olaf Ninnemann, Lina Issa
Publikováno v:
Cellular and Molecular Life Sciences. 68:1719-1736
Cyclin dependent kinase 5 regulatory subunit-associated protein 2 (CDK5RAP2) has gained attention in the last years following the discovery, in 2005, that recessive mutations cause primary autosomal recessive microcephaly. This disease is seen as an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e8bd373d54b398d4d45f08e77887a8c
https://doi.org/10.1007/s00018-011-0635-4
https://doi.org/10.1007/s00018-011-0635-4
Autor:
Markus Schuelke, Elena E. Pohl, Stefan Schumacher, Robert Nitsch, Irina Sarilova, Sandra Techritz, Anja U. Bräuer, Kristin Franke, Alina Smorodchenko, Olaf Ninnemann, Anne Rupprecht
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1788:2309-2319
UCP4 is a member of the mitochondrial uncoupling protein subfamily and one of the three UCPs (UCP2, UCP4, UCP5), associated with the nervous system. Its putative functions include thermogenesis, attenuation of reactive oxidative species (ROS), regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df863ad324e0dca99e947c81d841e6e
https://doi.org/10.1016/j.bbamem.2009.07.018
https://doi.org/10.1016/j.bbamem.2009.07.018
Autor:
Nadine, Kraemer, Sylvie, Picker-Minh, Ansar A, Abbasi, Sebastian, Fröhler, Olaf, Ninnemann, Muhammad N, Khan, Ghazanfar, Ali, Wei, Chen, Angela M, Kaindl
Publikováno v:
Clinical genetics. 89(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::88d88d7b716cc8e3240d5ab9a897faaf
https://pubmed.ncbi.nlm.nih.gov/26548919
https://pubmed.ncbi.nlm.nih.gov/26548919
Autor:
Sami Zaqout, Ralph Gräf, Olaf Ninnemann, Angela M. Kaindl, Detlev Schindler, Ethiraj Ravindran, Nadine Kraemer, Andrea Seiler, Gerda Neubert
Biallelic mutations in the gene encoding centrosomal CDK5RAP2 lead to autosomal recessive primary microcephaly (MCPH), a disorder characterized by pronounced reduction in volume of otherwise architectonical normal brains and intellectual deficit. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceedbdc6a39c442f2092276e1a736c5f
https://publishup.uni-potsdam.de/frontdoor/index/index/docId/38766
https://publishup.uni-potsdam.de/frontdoor/index/index/docId/38766
