Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Olaf, Jöhren"'
Autor:
Leonardo Vinicius Monteiro de Assis, Lisbeth Harder, Julica Inderhees, Olaf Jöhren, Jens Mittag, Henrik Oster
Publikováno v:
npj Metabolic Health and Disease, Vol 2, Iss 1, Pp 1-11 (2024)
Abstract Thyroid hormones (THs) are critical regulators of systemic energy metabolism and homeostasis. In the liver, high TH action protects against steatosis by enhancing cholesterol and triglyceride turnover, with thyroid hormone receptor beta (THR
Externí odkaz:
https://doaj.org/article/18af0ed767dc401bbedc605c0f3c2bee
Autor:
Leonardo Vinicius Monteiro de Assis, Lisbeth Harder, Julica Inderhees, Olaf Jöhren, Jens Mittag, Henrik Oster
Publikováno v:
npj Metabolic Health and Disease, Vol 2, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/0719e5942a504742a36878dab8642309
Autor:
Philip Harrer, Julica Inderhees, Chen Zhao, Barbara Schormair, Erik Tilch, Christian Gieger, Annette Peters, Olaf Jöhren, Thomas Fleming, Peter P. Nawroth, Klaus Berger, Marco Hermesdorf, Juliane Winkelmann, Markus Schwaninger, Konrad Oexle
Publikováno v:
EBioMedicine, Vol 101, Iss , Pp 105007- (2024)
Summary: Background: The dicarbonyl compounds methylglyoxal (MG), glyoxal (GO) and 3-deoxyglucosone (3-DG) have been linked to various diseases. However, disease-independent phenotypic and genotypic association studies with phenome-wide and genome-wi
Externí odkaz:
https://doaj.org/article/c87523ca0c424d7f8f197fe4dbad99de
Autor:
Rebecca Oelkrug, Lisbeth Harder, Mehdi Pedaran, Anne Hoffmann, Beke Kolms, Julica Inderhees, Sogol Gachkar, Julia Resch, Kornelia Johann, Olaf Jöhren, Kerstin Krause, Jens Mittag
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract It is well established that maternal thyroid hormones play an important role for the developing fetus; however, the consequences of maternal hyperthyroidism for the offspring remain poorly understood. Here we show in mice that maternal 3,3
Externí odkaz:
https://doaj.org/article/844930c5b5ce429bbad8e1a4fed79f71
Autor:
Kimberly Begemann, Isabel Heyde, Pia Witt, Julica Inderhees, Brinja Leinweber, Christiane E. Koch, Olaf Jöhren, Rebecca Oelkrug, Arkadiusz Liskiewicz, Timo D. Müller, Henrik Oster
Publikováno v:
Molecular Metabolism, Vol 69, Iss , Pp 101691- (2023)
Objective: Snacking, i.e., the intake of small amounts of palatable food items, is a common behavior in modern societies, promoting overeating and obesity. Shifting food intake into the daily rest phase disrupts circadian rhythms and is also known to
Externí odkaz:
https://doaj.org/article/8ced6dcdd0ec49f79f8163cec6b39dee
Autor:
Alessandro Di Spiezio, Elvira Sonia Sandin, Riccardo Dore, Helge Müller-Fielitz, Steffen E. Storck, Mareike Bernau, Walter Mier, Henrik Oster, Olaf Jöhren, Claus U. Pietrzik, Hendrik Lehnert, Markus Schwaninger
Publikováno v:
Molecular Metabolism, Vol 8, Iss , Pp 13-22 (2018)
Objective: Leptin is a key hormone in the control of appetite and body weight. Predominantly produced by white adipose tissue, it acts on the brain to inhibit homeostatic feeding and food reward. Leptin has free access to circumventricular organs, su
Externí odkaz:
https://doaj.org/article/f16f2cfd419748e59d456e48e28cc416
Autor:
Daniel Stephan, Natalie Taege, Riccardo Dore, Julica Folberth, Olaf Jöhren, Markus Schwaninger, Hendrik Lehnert, Carla Schulz
Publikováno v:
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 54(11)
Nesfatin-1, the cleavage product of nucleobindin-2, is an anorexigenic peptide and major regulator of energy homeostasis. Beyond reducing food intake and increasing energy expenditure, it is also involved in regulating the stress response. Interactio
Autor:
Misa Hirose, Axel Künstner, Paul Schilf, Anna Katharina Tietjen, Olaf Jöhren, Patricia Huebbe, Gerald Rimbach, Jan Rupp, Markus Schwaninger, Hauke Busch, Saleh M. Ibrahim
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 9, p 2359 (2019)
In this study, we provide experimental evidence that a maternally inherited polymorphism in the mitochondrial cytochrome b gene (mt-Cytb; m.15124A>G, Ile-Val) in mitochondrial complex III resulted in middle-aged obesity and higher susceptibility to d
Externí odkaz:
https://doaj.org/article/3043b84b77174766b99c1d69387fc96c
Endogenous NUCB2/Nesfatin-1 Regulates Energy Homeostasis Under Physiological Conditions in Male Rats
Autor:
Olaf Jöhren, Kerstin Wernecke, Riccardo Dore, Carla Schulz, Johanna Kahrs, Anna-Maria Wilz, Hendrik Lehnert, Lena Appel
Publikováno v:
Hormone and Metabolic Research. 52:676-684
Nesfatin-1 is the proteolytic cleavage product of Nucleobindin 2, which is expressed both in a number of brain nuclei (e. g., the paraventricular nucleus of the hypothalamus) and peripheral tissues. While Nucleobindin 2 acts as a calcium binding prot
Autor:
Carla Schulz, Regina Krotenko, Olaf Jöhren, Tamas L. Horvath, Markus Schwaninger, Alessandro Di Spiezio, Jan Philipp Reising, Hendrik Lehnert, Jens Mittag, Luca Murru, Riccardo Dore, Helge Müller-Fielitz, Marya Shanabrough, Maria Passafaro, Sivaraj Mohana Sundaram
Publikováno v:
Neuropsychopharmacology. 45:1645-1655
Homeostatic and hedonic pathways distinctly interact to control food intake. Dysregulations of circuitries controlling hedonic feeding may disrupt homeostatic mechanisms and lead to eating disorders. The anorexigenic peptides nucleobindin-2 (NUCB2)/n