Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Olaf, Groß"'
Autor:
Isis Wolf, Jonas Storz, Susanne Schultze-Seemann, Philipp R. Esser, Stefan F. Martin, Susan Lauw, Peer Fischer, Marie Peschers, Wolfgang Melchinger, Robert Zeiser, Oliver Gorka, Olaf Groß, Christian Gratzke, Reinhard Brückner, Philipp Wolf
Publikováno v:
Bioactive Materials, Vol 41, Iss , Pp 537-552 (2024)
Photoimmunotherapy (PIT) combines the specificity of antibodies with the cytotoxicity of light activatable photosensitizers (PS) and is a promising new cancer therapy. We designed and synthesized, in a highly convergent manner, the silicon phthalocya
Externí odkaz:
https://doaj.org/article/ee35b5cb8cf245868148c021c5ec968b
Autor:
Fabian Hersperger, Tim Meyring, Pia Weber, Chintan Chhatbar, Gianni Monaco, Marc S Dionne, Katrin Paeschke, Marco Prinz, Olaf Groß, Anne-Kathrin Classen, Katrin Kierdorf
Publikováno v:
eLife, Vol 12 (2024)
Environmental factors, infection, or injury can cause oxidative stress in diverse tissues and loss of tissue homeostasis. Effective stress response cascades, conserved from invertebrates to mammals, ensure reestablishment of homeostasis and tissue re
Externí odkaz:
https://doaj.org/article/73eb2793298442e9a0c9ec15b7293262
Autor:
Anke Schumann, Marion Brutsche, Monique Havermans, Sarah C. Grünert, Stefan Kölker, Olaf Groß, Luciana Hannibal, Ute Spiekerkoetter
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Methylmalonic aciduria (MMA-uria) is caused by deficiency of the mitochondrial enzyme methylmalonyl-CoA mutase (MUT). MUT deficiency hampers energy generation from specific amino acids, odd-chain fatty acids and cholesterol. Chronic kidney d
Externí odkaz:
https://doaj.org/article/78c8d21b0a0844deb166ddcbdc7c3b6e
Autor:
Haihua Guo, Manuel Rogg, Julia Keller, Ann-Kathrin Scherzinger, Julia Jäckel, Charlotte Meyer, Alena Sammarco, Martin Helmstädter, Oliver Gorka, Olaf Groß, Christoph Schell, Wibke Bechtel-Walz
Publikováno v:
Antioxidants, Vol 13, Iss 1, p 81 (2024)
(1) Background: Differentiated podocytes are particularly vulnerable to oxidative stress and cellular waste products. The disease-related loss of postmitotic podocytes is a direct indicator of renal disease progression and aging. Podocytes use highly
Externí odkaz:
https://doaj.org/article/9d0e7c481d1746ec910e91b95688da91
Autor:
Laura Griewahn, Madeleine Müller, Lukas Peintner, Manuela Wissler, Martina Weiss, Prisca Brauns-Schubert, Ramin Massoumi, Christoph Borner, Olaf Groß, Monica Yabal, Céline Charvet, Ulrich Maurer
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111961- (2023)
Summary: SPATA2 mediates the recruitment of CYLD to immune receptor complexes by bridging the interaction of CYLD with the linear ubiquitylation assembly complex (LUBAC) component HOIP. Whether SPATA2 exhibits functions independently of CYLD is uncle
Externí odkaz:
https://doaj.org/article/e86bc9e4cce94274b37f594cfa34c61e
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Oncogenic signalling has been historically associated with sustained cancer cell-intrinsic proliferation, however its role in promoting tumour immunoresistance has also become evident. Here, Hamarsheh and colleagues review and discuss the preclinical
Externí odkaz:
https://doaj.org/article/bab2055f90cc4a4aa21071e579d430b6
Autor:
Shaima’a Hamarsheh, Lena Osswald, Benedikt S. Saller, Susanne Unger, Donatella De Feo, Janaki Manoja Vinnakota, Martina Konantz, Franziska M. Uhl, Heiko Becker, Michael Lübbert, Khalid Shoumariyeh, Christoph Schürch, Geoffroy Andrieux, Nils Venhoff, Annette Schmitt-Graeff, Sandra Duquesne, Dietmar Pfeifer, Matthew A. Cooper, Claudia Lengerke, Melanie Boerries, Justus Duyster, Charlotte M. Niemeyer, Miriam Erlacher, Bruce R. Blazar, Burkard Becher, Olaf Groß, Tilman Brummer, Robert Zeiser
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Oncogenic Ras mutations are common drivers in myeloid leukemia. Here, the authors show in patient cells and in mice that oncogenic K-Ras activates NLRP3 inflammasome to drive myeloproliferation, which can be reversed by genetic or pharmacologic NLRP3
Externí odkaz:
https://doaj.org/article/8d60e15645a540748f0978aece6a6bc5
Autor:
Ying-Yin Chao, Alisa Puhach, David Frieser, Mahima Arunkumar, Laurens Lehner, Thomas Seeholzer, Albert Garcia-Lopez, Marlot van der Wal, Silvia Fibi-Smetana, Axel Dietschmann, Thomas Sommermann, Tamara Ćiković, Leila Taher, Mark S. Gresnigt, Sebastiaan J. Vastert, Femke van Wijk, Gianni Panagiotou, Daniel Krappmann, Olaf Groß, Christina E. Zielinski
Publikováno v:
Nature Immunology. 24:295-308
It has been shown that innate immune responses can adopt adaptive properties such as memory. Whether T cells utilize innate immune signaling pathways to diversify their repertoire of effector functions is unknown. Gasdermin E (GSDME) is a membrane po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92bcd8312dc3f137a187cc7cbaa49676
https://doi.org/10.1038/s41590-022-01386-w
https://doi.org/10.1038/s41590-022-01386-w
Autor:
Katrin Kierdorf, Fabian Hersperger, Jessica Sharrock, Crystal M Vincent, Pinar Ustaoglu, Jiawen Dou, Attila Gyoergy, Olaf Groß, Daria E Siekhaus, Marc S Dionne
Publikováno v:
eLife, Vol 9 (2020)
Unpaired ligands are secreted signals that act via a GP130-like receptor, domeless, to activate JAK/STAT signalling in Drosophila. Like many mammalian cytokines, unpaireds can be activated by infection and other stresses and can promote insulin resis
Externí odkaz:
https://doaj.org/article/cfd49166d2854e07bbaa0911e97a29c0
Autor:
Lydia Kasper, Annika König, Paul-Albert Koenig, Mark S. Gresnigt, Johannes Westman, Rebecca A. Drummond, Michail S. Lionakis, Olaf Groß, Jürgen Ruland, Julian R. Naglik, Bernhard Hube
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-20 (2018)
Phagocytic cells of the innate immune system play critical roles in defence against invading pathogens including the opportunistic pathogen Candida albicans. Here the authors show that C. albicans derived Candidalysin in addition to being a cell-dama
Externí odkaz:
https://doaj.org/article/5324ba10a64d4c6bbae3366e1c0cfbac