Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Ola H Negm"'
Autor:
Ola H Negm, Mohamed R Hamed, Robert E Schoen, Richard L Whelan, Robert J Steele, John Scholefield, Elizabeth M Dilnot, H M C Shantha Kumara, John F R Robertson, Herbert F Sewell
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0156971 (2016)
Colorectal cancer (CRC) is the second most common malignancy in the western world. Early detection and diagnosis of all cancer types is vital to improved prognosis by enabling early treatment when tumours should be both resectable and curable. Sera f
Externí odkaz:
https://doaj.org/article/c8dee0905a3840ccbf39eb0bb574f986
Publikováno v:
Immunology
The tumour necrosis factor receptor superfamily (TNFRSF) members contain cysteine-rich domains (CRD) in their extracellular regions, and the membrane-distal CRD1 forms homologous interactions in the absence of ligand. The CRD1 is therefore termed a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568a1598da3fbd8ece6a516ec9a25a0f
https://europepmc.org/articles/PMC8517588/
https://europepmc.org/articles/PMC8517588/
Autor:
Elizabeth M. McDermott, Ola H. Negm, W Abduljabbar, Patrick J. Tighe, Lucy C. Fairclough, Paul M. Radford, Elizabeth Drewe, Sonali Singh, Mohamed R. Hamed, Ian Todd
Publikováno v:
Clin Exp Immunol
Summary Tumour necrosis factor receptor-associated periodic syndrome (TRAPS) is a hereditary autoinflammatory disorder characterized by recurrent episodes of fever and inflammation. It is associated with autosomal dominant mutations in TNFRSF1A, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ea14307a581ff534cb67654460067e
https://doi.org/10.1111/cei.13306
https://doi.org/10.1111/cei.13306
Autor:
Senthooran Selvarajah, Ola H. Negm, Mohamed R. Hamed, Carolyn Tubby, Ian Todd, Patrick J. Tighe, Tim Harrison, Lucy C. Fairclough
Publikováno v:
Mediators of Inflammation, Vol 2014 (2014)
Externí odkaz:
https://doaj.org/article/40ec4b9e0b24412f982bf4416de56ddf
Publikováno v:
Toxicology Letters. 299:40-46
Cigarette smoke has significant toxic effects on the immune system, and increases the risk of developing autoimmune diseases; one immunosuppressive effect of cigarette smoke is that it inhibits the T cell-stimulating, immunogenic properties of myeloi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d502f5806bb982199176ed4c29d3f37b
https://doi.org/10.1016/j.toxlet.2018.09.002
https://doi.org/10.1016/j.toxlet.2018.09.002
Autor:
Patrick J. Tighe, Peter Wigmore, Lucy C. Fairclough, S.E. Shortall, Ola H. Negm, Madeleine V. King, Maxine J Fowler
Publikováno v:
Molecular Neurobiology. 55:7413-7430
Post-weaning social isolation of rats produces neuroanatomical, neurochemical and behavioral alterations resembling some core features of schizophrenia. This study examined the ability of the 5-HT6 receptor antagonist SB-399885 to reverse isolation-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79d00af2cce7f1e32647f31b92ab50e8
https://doi.org/10.1007/s12035-018-0940-0
https://doi.org/10.1007/s12035-018-0940-0
Autor:
Paul M. Radford, Mohamed R. Hamed, Jon Garibaldi, Patrick J. Tighe, Sharon Patricia Mary Crouch, Lucy C. Fairclough, Ola H. Negm, Grazziela P. Figueredo, Ian Todd, Elizabeth M. McDermott, Steve St-Gallay, Jenna Reps, Elizabeth Drewe, Richard J. Powell, Susan E. Bainbridge
Publikováno v:
Pharmacological Research. 125:188-200
TNF Receptor Associated Periodic Syndrome (TRAPS) is an autoinflammatory disease caused by mutations in TNF Receptor 1 (TNFR1). Current therapies for TRAPS are limited and do not target the pro-inflammatory signalling pathways that are central to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf40a79a3432fb9ed5b2ec4a6ffc5c6
https://doi.org/10.1016/j.phrs.2017.08.012
https://doi.org/10.1016/j.phrs.2017.08.012
Autor:
Mohamed R. Hamed, Clifford C. Shone, Brendon MacKenzie, K. Ravi Acharya, Tanya Monaghan, Ola H. Negm, Mark H. Wilcox, David P. Humphreys
Publikováno v:
Clinical and Experimental Gastroenterology. 10:169-175
Objectives: Despite multiple risk factors and a high rate of colonization for Clostridium difficile, the occurrence of C. difficile infection in patients with cystic fibrosis is rare. The aim of this study was to compare the prevalence of binding C.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::625f4a91fecd62d98364c7bf2bb481e2
https://doi.org/10.2147/ceg.s133939
https://doi.org/10.2147/ceg.s133939
Autor:
Patrick J. Tighe, John F.R. Robertson, Keith Evans, Ola H. Negm, Peng Shi, Herbert F. Sewell, Jonathan M. Garibaldi, Grazziela P. Figueredo, Andrew J. Parkes
Publikováno v:
CEC
Current methods to identify cut-off values for tumour-associated molecules (antigens) discrimination are based on statistics and brute force. These methods applied to cancer screening problems are very inefficient, especially with large data sets wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d10caad5fb74c9fa18a42dd9011b199
https://doi.org/10.1109/cec.2019.8790316
https://doi.org/10.1109/cec.2019.8790316
Autor:
Mohamed R. Hamed, M. Layth Alabdullah, Vimla Band, Ian O. Ellis, Dena Ahmad, Ola H. Negm, Sameer Mirza, Emad A. Rakha, Andrew R. Green
Publikováno v:
Breast Cancer Research and Treatment
Background Mitogen-activated protein kinases (MAPKs) are signalling transduction molecules that have different functions and diverse behaviour in cancer. In breast cancer, MAPK is related to oestrogen receptor (ER) and HER2. Methods Protein expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6bc1bd239dd474fa53391ead46b25a
http://europepmc.org/articles/PMC5021722
http://europepmc.org/articles/PMC5021722