Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Oksana Weichel"'
Excitotoxic Hippocampal Membrane Breakdown and its Inhibition by Bilobalide: Role of Chloride Fluxes
Publikováno v:
Pharmacopsychiatry. 36:78-83
We have previously shown that hypoxia and N-methyl-D-aspartate (NMDA) receptor activation induce breakdown of choline-containing phospholipids in rat hippocampus, a process which is mediated by calcium influx and phospholipase A (2) activation. Bilob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22345157a459117d8ba50befd3be5700
https://doi.org/10.1055/s-2003-40453
https://doi.org/10.1055/s-2003-40453
Publikováno v:
Journal of Neurochemistry. 80:843-849
Choline (Ch) is an essential nutrient as the biosynthetic precursor of acetylcholine (ACh) and phospholipids. Under resting conditions, the intracellular accumulation of Ch (above 10-fold), which is positively charged, is governed by the membrane pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c2b1cba61b57bd131caf0fca0cbe23
https://doi.org/10.1046/j.0022-3042.2001.00754.x
https://doi.org/10.1046/j.0022-3042.2001.00754.x
Autor:
Ulrike Kempter, Petra Seimetz, Ira Böckmann, Jan Drappatz, Mark Waring, Oksana Weichel, Elisabet Sarri, Angela Valeva, Jochen Klein
Publikováno v:
FEBS Letters. 464:21-24
Neuronal phospholipase D (PLD) activity was hypothesized to be involved in vesicle trafficking and endocytosis and, possibly, transmitter release. We here report that prolonged depolarization of rat hippocampal slices by potassium chloride (KCl) or 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ab3161804e742a3858fde36a6dbd0c1
https://doi.org/10.1016/s0014-5793(99)01669-5
https://doi.org/10.1016/s0014-5793(99)01669-5
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 360:609-615
In rat hippocampal slices superfused with magnesium-free buffer, glutamate (1 mM) caused the release of large amounts of choline due to phospholipid breakdown. This phenomenon was mimicked by N-methyl-D-aspartate (NMDA) in a calcium-sensitive manner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c80a5b00fbafe7536aebfc85d2b7a8
https://doi.org/10.1007/s002109900131
https://doi.org/10.1007/s002109900131
Autor:
Ulrike Korth, Joachim Hartmann, Andrea Schmitt, Marion Hilgert, Klaus Fassbender, Jochen Klein, Oksana Weichel, Michael Hilgert, Anna Walter
Publikováno v:
Neurobiology of aging. 25(10)
Experimental and clinical studies give evidence for breakdown of membrane phospholipids during neurodegeneration. In the present study, we measured the levels of glycerophosphocholine (GPCh), phosphocholine (PCh), and choline, that is, water-soluble
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e286bfecdb31b39bae376cf487ae12
https://pubmed.ncbi.nlm.nih.gov/15465626
https://pubmed.ncbi.nlm.nih.gov/15465626
Publikováno v:
Biochemical and biophysical research communications. 297(3)
Induction of expression and proteolytic breakdown of phospholipase D (PLD) isoforms in primary astrocyte cultures have been investigated. Astrocytes express both PLD1 and 2 and are dependent on PLD activity for cell proliferation [K. Kotter, J. Klein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a7cc7d1275a5c6c341825bb00a65d0
https://pubmed.ncbi.nlm.nih.gov/12270129
https://pubmed.ncbi.nlm.nih.gov/12270129
Autor:
Susanne Strauch, Iwan Walev, Sucharit Bhakdi, Angela Valeva, Jochen Klein, Matthias Husmann, Oksana Weichel, Heiner Wirtz
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 164(10)
We report that potassium leakage from cells leads to activation of the Ca2+-independent phospholipase A2 (iPLA2), and the latter plays a pivotal role in regulating the cleavage of pro-IL-1β by the IL-converting enzyme caspase-1 in human monocytes. K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0f98e73d1963ae3527fb267cf2a180
https://pubmed.ncbi.nlm.nih.gov/10799869
https://pubmed.ncbi.nlm.nih.gov/10799869
Autor:
Elisabet Sarri, Ulrike Kempter, Jochen Klein, Ira Böckmann, Angela Valeva, Christoph von Eichel-Streiber, Oksana Weichel
Publikováno v:
FEBS letters. 440(3)
In order to investigate the regulation of presynaptic phospholipase D (PLD) activity by calcium and G proteins, we established a permeabilization procedure for rat cortical synaptosomes using Staphylococcus aureus alpha-toxin (30-100 microg/ml). In p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86661f4d75ee22adf15043c46fad8ba8
https://pubmed.ncbi.nlm.nih.gov/9872388
https://pubmed.ncbi.nlm.nih.gov/9872388