Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Oksana Voloshanenko"'
Allele-specific endogenous tagging and quantitative analysis of β-catenin in colorectal cancer cells
Autor:
Giulia Ambrosi, Oksana Voloshanenko, Antonia F Eckert, Dominique Kranz, G Ulrich Nienhaus, Michael Boutros
Publikováno v:
eLife, Vol 11 (2022)
Wnt signaling plays important roles in development, homeostasis, and tumorigenesis. Mutations in β-catenin that activate Wnt signaling have been found in colorectal and hepatocellular carcinomas. However, the dynamics of wild-type and mutant forms o
Externí odkaz:
https://doaj.org/article/6a4cebd9d4ab403c9ac8d82a751b22e4
Autor:
Benedikt Rauscher, Florian Heigwer, Luisa Henkel, Thomas Hielscher, Oksana Voloshanenko, Michael Boutros
Publikováno v:
Molecular Systems Biology, Vol 14, Iss 2, Pp 1-17 (2018)
Abstract Cancer genomes often harbor hundreds of molecular aberrations. Such genetic variants can be drivers or passengers of tumorigenesis and create vulnerabilities for potential therapeutic exploitation. To identify genotype‐dependent vulnerabil
Externí odkaz:
https://doaj.org/article/976451cedcc74a589433ae90e6e6e00f
Autor:
Giusi Moffa, Gerrit Erdmann, Oksana Voloshanenko, Christian Hundsrucker, Mohammad J Sadeh, Michael Boutros, Rainer Spang
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0155999 (2016)
Cellular signalling pathways consolidate multiple molecular interactions into working models of signal propagation, amplification, and modulation. They are described and visualized as networks. Adjusting network topologies to experimental data is a k
Externí odkaz:
https://doaj.org/article/eaee9ebd01ce49c3bd51a7aeaa48ac2a
Autor:
Ingmar Sören, Meyer, Xue, Li, Carina, Meyer, Oksana, Voloshanenko, Susann, Pohl, Michael, Boutros, Hugo Albert, Katus, Norbert, Frey, Florian, Leuschner
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 20; Pages: 12252
Wnt (a portmanteau of Wingless and Int-1) signaling in the adult heart is largely quiescent. However, there is accumulating evidence that it gets reactivated during the healing process after myocardial infarction (MI). We here tested the therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f594211566d2567f3f1c5a0eee69808
Autor:
Antonia Schubert, Oksana Voloshanenko, Franziska Ragaller, Philipp Gmach, Dominique Kranz, Christian Scheeder, Thilo Miersch, Matthias Schulz, Lorenz Trümper, Claudia Binder, Marko Lampe, Ulrike Engel, Michael Boutros
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(30)
During organismal development, homeostasis, and disease, Dishevelled (Dvl) proteins act as key signaling factors in beta-catenin–dependent and beta-catenin–independent Wnt pathways. While their importance for signal transmission has been genetica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753bfecdc16cd5d698c77749d3369317
https://pubmed.ncbi.nlm.nih.gov/35867833
https://pubmed.ncbi.nlm.nih.gov/35867833
Autor:
Giulia Ambrosi, Oksana Voloshanenko, Antonia F Eckert, Dominique Kranz, G Ulrich Nienhaus, Michael Boutros
Publikováno v:
eLife, 11
eLife
eLife, Vol 11 (2022)
eLife
eLife, Vol 11 (2022)
Wnt signaling plays important roles in development, homeostasis, and tumorigenesis. Mutations in β-catenin that activate Wnt signaling have been found in colorectal and hepatocellular carcinomas. However, the dynamics of wild-type and mutant forms o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0df2dbf602422c7c8a9ce13a3bc05fc
Autor:
Dominique Kranz, Antonia F. Eckert, Giulia Ambrosi, Oksana Voloshanenko, G. Ulrich Nienhaus, Michael Boutros
Wnt signaling plays important roles in embryonic development and during tissue homeostasis, and its deregulation contributes to the onset and progression of tumors. beta-catenin is a key component of the canonical Wnt pathway. Upon activation of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cacf002c26c21d04ee8e51d2b17faef
https://doi.org/10.1101/2020.06.18.159616
https://doi.org/10.1101/2020.06.18.159616
Autor:
Oksana Voloshanenko, Benedikt Rauscher, Dominique Kranz, Iris Augustin, Uwe Schwartz, Michael Boutros, Michael Linnebacher
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports
Scientific Reports
Wnt signaling is an evolutionarily conserved signaling route required for development and homeostasis. While canonical, β-catenin-dependent Wnt signaling is well studied and has been linked to many forms of cancer, much less is known about the role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d41e0a41574d908fe08ba1188818faa
http://link.springer.com/article/10.1038/s41598-018-20641-5
http://link.springer.com/article/10.1038/s41598-018-20641-5
Publikováno v:
The FASEB Journal
Signaling pathway modules are often encoded by several closely related paralogous genes that can have redundant roles and are therefore difficult to analyze by loss-of-function analysis. A typical example is the Wnt signaling pathway, which in mammal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::915bad63107e729383cd3fb64a8d2243
https://doi.org/10.1096/fj.201700144r
https://doi.org/10.1096/fj.201700144r