Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Oksana Tsyklauri"'
Autor:
Oksana Tsyklauri, Tereza Chadimova, Veronika Niederlova, Jirina Kovarova, Juraj Michalik, Iva Malatova, Sarka Janusova, Olha Ivashchenko, Helene Rossez, Ales Drobek, Hana Vecerova, Virginie Galati, Marek Kovar, Ondrej Stepanek
Publikováno v:
eLife, Vol 12 (2023)
Regulatory T cells (Tregs) are indispensable for maintaining self-tolerance by suppressing conventional T cells. On the other hand, Tregs promote tumor growth by inhibiting anticancer immunity. In this study, we identified that Tregs increase the quo
Externí odkaz:
https://doaj.org/article/1259c927d0e9455aaea1c7377dffc5bd
Autor:
Matouš Vobořil, Tomáš Brabec, Jan Dobeš, Iva Šplíchalová, Jiří Březina, Adéla Čepková, Martina Dobešová, Aigerim Aidarova, Jan Kubovčiak, Oksana Tsyklauri, Ondřej Štěpánek, Vladimír Beneš, Radislav Sedláček, Ludger Klein, Michal Kolář, Dominik Filipp
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Immune tolerance is mediated by the deletion of autoreactive T cells via medullary thymic epithelial cells (mTEC) and dendritic cells (DC), and by the induction of regulatory T cells (Treg). Here the authors show that mTEC receiving toll-like recepto
Externí odkaz:
https://doaj.org/article/17ae763d83f941499c6713566243bf8e
Autor:
Veronika Horkova, Ales Drobek, Darina Paprckova, Veronika Niederlova, Avishek Prasai, Valeria Uleri, Daniela Glatzova, Markus Kraller, Michaela Cesnekova, Sarka Janusova, Eva Salyova, Oksana Tsyklauri, Theresa A. Kadlecek, Katerina Krizova, René Platzer, Kilian Schober, Dirk H. Busch, Arthur Weiss, Johannes B. Huppa, Ondrej Stepanek
Publikováno v:
Nature Immunology. 24:174-185
The kinase LCK and CD4/CD8 co-receptors are crucial components of the T cell antigen receptor (TCR) signaling machinery, leading to key T cell fate decisions. Despite decades of research, the roles of CD4–LCK and CD8–LCK interactions in TCR trigg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558e5771858f2dd70484f422099c8b4e
https://doi.org/10.1038/s41590-022-01366-0
https://doi.org/10.1038/s41590-022-01366-0
Autor:
Oksana Tsyklauri, Tereza Chadimova, Veronika Niederlova, Jirina Kovarova, Juraj Michalik, Iva Malatova, Sarka Janusova, Olha Ivashchenko, Helene Rossez, Ales Drobek, Hana Vecerova, Virginie Galati, Marek Kovar, Ondrej Stepanek
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2857041c2c03a18ec255c7325fd3a87
https://doi.org/10.7554/elife.79342.sa2
https://doi.org/10.7554/elife.79342.sa2
Publikováno v:
European Journal of Immunology. 51:512-530
Regulatory T cells (Tregs) play a key role in the peripheral self-tolerance and preventing autoimmunity. While classical CD4+ Foxp3+ Tregs are well established, their CD8+ counterparts are still controversial in many aspects including their phenotypi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1067358bac9f6f48710b424e5f6725a
https://doi.org/10.1002/eji.202048614
https://doi.org/10.1002/eji.202048614
Autor:
Adéla Čepková, Radislav Sedlacek, Jan Kubovciak, Martina Dobešová, Aigerim Aidarova, Iva Splichalova, Dominik Filipp, Matouš Vobořil, Oksana Tsyklauri, Jan Dobeš, Vladimir Benes, Ludger Klein, Jiří Březina, Tomáš Brabec, Ondřej Štěpánek, Michal Kolář
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
The development of thymic regulatory T cells (Treg) is mediated by Aire-regulated self-antigen presentation on medullary thymic epithelial cells (mTECs) and dendritic cells (DCs), but the cooperation between these cells is still poorly understood. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1c9835ed04cea2d64ce66fde601727
https://doaj.org/article/17ae763d83f941499c6713566243bf8e
https://doaj.org/article/17ae763d83f941499c6713566243bf8e
Autor:
Ales Drobek, Juraj Michalik, Helene Rossez, Iva Malatova, Ondrej Stepanek, Marek Kovar, Hana Vecerova, Veronika Niederlova, Sarka Janusova, Virginie Galati, Jirina Kovarova, Oksana Tsyklauri, Tereza Chadimova
Regulatory T cells (Tregs) are indispensable for maintaining self-tolerance by suppressing conventional T cells. On the other hand, Tregs promote tumor growth by inhibiting anti-cancer immunity. In this study, we identified that Tregs increase the qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::599aeca3e9b07d430f109c214a4a66f9
https://doi.org/10.1101/2021.11.10.467495
https://doi.org/10.1101/2021.11.10.467495
Autor:
Daniela Knizkova, Michaela Pribikova, Helena Draberova, Tereza Semberova, Tijana Trivic, Alzbeta Synackova, Andrea Ujevic, Jana Stefanovic, Ales Drobek, Martina Huranova, Veronika Niederlova, Oksana Tsyklauri, Ales Neuwirth, Jolana Tureckova, Ondrej Stepanek, Peter Draber
Publikováno v:
Nature immunology. 23(11)
Interleukin-17A (IL-17A) is a key mediator of protective immunity to yeast and bacterial infections but also drives the pathogenesis of several autoimmune diseases, such as psoriasis or psoriatic arthritis. Here we show that the tetra-transmembrane p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceabebc79faeda124acb3b1e6f53ce94
https://pubmed.ncbi.nlm.nih.gov/36445938
https://pubmed.ncbi.nlm.nih.gov/36445938
Publikováno v:
Human Mutation. 40:2068-2087
Bardet-Biedl syndrome (BBS) is a recessive genetic disease causing multiple organ anomalies. Most patients carry mutations in genes encoding for the subunits of the BBSome, an octameric ciliary transport complex, or accessory proteins involved in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01549227170c15618e98d81e42411d6
https://doi.org/10.1002/humu.23862
https://doi.org/10.1002/humu.23862
Autor:
Martina Huranova, Oksana Tsyklauri, Ales Drobek, Radislav Sedlacek, Kathryn Sparks, Jan Prochazka, Ondrej Stepanek, Petr Kasparek, Avishek Prasai, Philip L. Beales, Zdenek Trachtulec, Elizabeth Forsythe, Veronika Niederlova
Publikováno v:
EMBO Rep
Bardet-Biedl Syndrome (BBS) is a pleiotropic genetic disease caused by the dysfunction of primary cilia. The immune system of patients with ciliopathies has not been investigated. However, there are multiple indications that the impairment of the pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30c61231b232ece70ac6ba8ed4549eb2
https://doi.org/10.15252/embr.202050785
https://doi.org/10.15252/embr.202050785