Zobrazeno 1 - 10 of 54 pro vyhledávání: '"Oksana Sirenko"'
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Akademický článek
Multifunctional profiling of triple-negative breast cancer patient-derived tumoroids for disease modeling
Autor: Evan F Cromwell, Oksana Sirenko, Ekaterina Nikolov, Matthew Hammer, Courtney K Brock, Margarite D Matossian, Madlin S Alzoubi, Bridgette M Collins-Burow, Matthew E Burow
Publikováno v: SLAS Discovery, Vol 27, Iss 3, Pp 191-200 (2022)
3D cell models derived from patient tumors are highly translational tools that can recapitulate the complex genetic and molecular compositions of solid cancers and accelerate identification of drug targets and drug testing. However, the complexity of
Externí odkaz: https://doaj.org/article/434a840853bb4244814deff2f67e2e23
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2
Disease Modeling with 3D Cell-Based Assays Using a Novel Flowchip System and High-Content Imaging
Autor: Rashmi Rajendra, Michelle Leung, Matthew Hammer, Evan F. Cromwell, Anthony Thai, Oksana Sirenko
Publikováno v: SLAS Technology. 26:237-248
There is an increasing interest in using three-dimensional (3D) cell structures for modeling tumors, organs, and tissue to accelerate translational research. We describe here a novel automated organoid assay system (the Pu·MA System) combined with m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::624a1de7e2b2e7801878ba4b742cf2e3
https://doi.org/10.1177/24726303211000688
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3
Evaluating Drug Response in 3D Triple Negative Breast Cancer Tumoroids with High Content Imaging and Analysis
Autor: Oksana Sirenko, Courtney K Brock, Angeline Lim, Prathyushakrishna Macha, Ekaterina Nikolov, Cathy Olsen, Emily C. McConnell, Maryl Wright, Bridgette M Collins-Burow, Evan F Cromwell, Matthew E Burow
There is a critical need to develop methods for efficient testing of drug efficacy in patient-derived tumor samples to discover new therapeutics. Two-dimensional (2D) cell culture remains the primary method of drug screening, despite being considered
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f5d63b29e631f183791f75b282cc7b6
https://doi.org/10.21203/rs.3.rs-1859525/v1
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4
Abstract LB113: Bio-printed 3D cell models and high-content imaging for testing anti-cancer compounds
Autor: Prathyushakrishna Macha, John Huang, Zhisong Tong, James B. Hoying, Oksana Sirenko
Publikováno v: Cancer Research. 83:LB113-LB113
The discovery and screening of anti-cancer drugs is a vast field that is constantly evolving. More advanced cell-based models are needed to have an efficient way of studying cellular and subcellular effects of compound treatments, especially in early
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aad3234e459cbb53878119bbd90f30d1
https://doi.org/10.1158/1538-7445.am2023-lb113
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7
Abstract 185: Monitoring metabolite dynamics in patient-derived tumoroids using automated microfluidic Pu·MA System
Autor: Ekaterina Nikolov, Oksana Sirenko, Matthew Hammer, Courtney Brock, Anthony Thai, Matthew Burow, Bridgette Collins-Burow, Evan Cromwell
Publikováno v: Cancer Research. 82:185-185
Introduction: Cancer cells are characterized by metabolic modifications to meet high bioenergetic and anabolic demand during tumorigenesis. For most tumors aerobic glycolysis is a major driver of cancer progression, resistance to therapy, poor patien
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa19dd63ff2fb11d7f459fd9854d8fd5
https://doi.org/10.1158/1538-7445.am2022-185
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8
Abstract 180: Automation and high content imaging of 3D triple negative breast cancer patient-derived tumoroids assay for compound screening
Autor: Oksana Sirenko, Angeline Lim, Courtney K. Brock, Katya Nikolov, Cathy Olsen, Evan F. Cromwell, Margarite D. Matossian, Matthew E. Burow
Publikováno v: Cancer Research. 82:180-180
Introduction: Currently there are no clinically approved small molecule targeted therapies for triple negative breast cancer, underlining the critical need to discover new therapeutic targets. Patient-derived cell-based 3D cancer models are highly va
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f26d511c4a0fc728e7f0d2cfbb842e44
https://doi.org/10.1158/1538-7445.am2022-180
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10
Effect of Combination of L-Arginine and L-Carnitine on Serum AGEs Level, Kidney and Endothelial Function in Patients with Chronic Heart Fa
Autor: Oksana Sirenko, Abdunaser A. Zabida, Olexandr Kuryata
Publikováno v: Journal of Nutritional Therapeutics. 7:77-83
The aim of the study to evaluate the effect of combination of L-Arginine with L-Carnitine on GFR, serum AGEs level and endothelial function in chronic heart failure (HF) patients with preserved ejection fraction (HFpEF). Materials and Methods: 35 pat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d9e3fe51ef2396e16e00d02c2b7e2b1
https://doi.org/10.6000/1929-5634.2018.07.03.2
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