Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Oksana Sintsova"'
Autor:
Oksana Sintsova, Darya Popkova, Aleksandr Kalinovskii, Anton Rasin, Natalya Borozdina, Elvira Shaykhutdinova, Anna Klimovich, Alexander Menshov, Natalia Kim, Stanislav Anastyuk, Mikhail Kusaykin, Igor Dyachenko, Irina Gladkikh, Elena Leychenko
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115743- (2023)
Diabetes mellitus is a serious threat to human health in both developed and developing countries. Optimal disease control requires the use of a diet and a combination of several medications, including oral hypoglycemic agents such as α-glucosidase i
Externí odkaz:
https://doaj.org/article/297f320926754531b825e09b094c4006
Autor:
Daria Popkova, Nadezhda Otstavnykh, Oksana Sintsova, Sergey Baldaev, Rimma Kalina, Irina Gladkikh, Marina Isaeva, Elena Leychenko
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2682 (2023)
Diabetes mellitus is one of the most serious diseases of our century. The drugs used are limited or have serious side effects. The search for new sources of compounds for effective treatment is relevant. Magnificamide, a peptide inhibitor of mammalia
Externí odkaz:
https://doaj.org/article/c08bd79ea261445b8cf2681916c1d8f2
Autor:
Oksana Sintsova, Irina Gladkikh, Anna Klimovich, Yulia Palikova, Viktor Palikov, Olga Styshova, Margarita Monastyrnaya, Igor Dyachenko, Sergey Kozlov, Elena Leychenko
Publikováno v:
Biomedicines, Vol 9, Iss 7, p 716 (2021)
Currently the TRPV1 (transient receptor potential vanilloid type 1) channel is considered to be one of the main targets for pro-inflammatory mediators including TNF-α. Similarly, the inhibition of TRPV1 activity in the peripheral nervous system affe
Externí odkaz:
https://doaj.org/article/730f420cbea54d599b0359b09e8e4ce6
Autor:
Oksana Sintsova, Irina Gladkikh, Margarita Monastyrnaya, Valentin Tabakmakher, Ekaterina Yurchenko, Ekaterina Menchinskaya, Evgeny Pislyagin, Yaroslav Andreev, Sergey Kozlov, Steve Peigneur, Jan Tytgat, Dmitry Aminin, Emma Kozlovskaya, Elena Leychenko
Publikováno v:
Biomedicines, Vol 9, Iss 3, p 283 (2021)
Kunitz-type peptides from venomous animals have been known to inhibit different proteinases and also to modulate ion channels and receptors, demonstrating analgesic, anti-inflammatory, anti-histamine and many other biological activities. At present,
Externí odkaz:
https://doaj.org/article/1e1b34edb4d842bf990c4fef7e0d9233
Autor:
Irina Gladkikh, Steve Peigneur, Oksana Sintsova, Ernesto Lopes Pinheiro-Junior, Anna Klimovich, Alexander Menshov, Anatoly Kalinovsky, Marina Isaeva, Margarita Monastyrnaya, Emma Kozlovskaya, Jan Tytgat, Elena Leychenko
Publikováno v:
Biomedicines, Vol 8, Iss 11, p 473 (2020)
The Kunitz/BPTI peptide family includes unique representatives demonstrating various biological activities. Electrophysiological screening of peptides HCRG1 and HCRG2 from the sea anemone Heteractis crispa on six Kv1.x channel isoforms and insect Sha
Externí odkaz:
https://doaj.org/article/5459fee03f8a4f228f7f7edb12628d46
Autor:
Irina Gladkikh, Margarita Monastyrnaya, Elena Zelepuga, Oksana Sintsova, Valentin Tabakmakher, Oksana Gnedenko, Alexis Ivanov, Kuo-Feng Hua, Emma Kozlovskaya
Publikováno v:
Marine Drugs, Vol 13, Iss 10, Pp 6038-6063 (2015)
Sea anemones are a rich source of Kunitz-type polypeptides that possess not only protease inhibitor activity, but also Kv channels toxicity, analgesic, antihistamine, and anti-inflammatory activities. Two Kunitz-type inhibitors belonging to a new Het
Externí odkaz:
https://doaj.org/article/fcb6c6c1946d4fb4a4c4709bd47ab617
Autor:
Oksana Sintsova, Irina Gladkikh, Aleksandr Kalinovskii, Elena Zelepuga, Margarita Monastyrnaya, Natalia Kim, Lyudmila Shevchenko, Steve Peigneur, Jan Tytgat, Emma Kozlovskaya, Elena Leychenko
Publikováno v:
Marine Drugs, Vol 17, Iss 10, p 542 (2019)
Sea anemones’ venom is rich in peptides acting on different biological targets, mainly on cytoplasmic membranes and ion channels. These animals are also a source of pancreatic α-amylase inhibitors, which have the ability to control the glucose lev
Externí odkaz:
https://doaj.org/article/71f1ac1df57149ff80b76811bcf6b041
Autor:
Margarita Monastyrnaya, Steve Peigneur, Elena Zelepuga, Oksana Sintsova, Irina Gladkikh, Elena Leychenko, Marina Isaeva, Jan Tytgat, Emma Kozlovskaya
Publikováno v:
Marine Drugs, Vol 14, Iss 12, p 229 (2016)
Sea anemone venoms comprise multifarious peptides modulating biological targets such as ion channels or receptors. The sequence of a new Kunitz-type peptide, HCRG21, belonging to the Heteractis crispa RG (HCRG) peptide subfamily was deduced on the ba
Externí odkaz:
https://doaj.org/article/29e6a5f8c8c54a60b80ba60c40b249d6
Autor:
Y. A. Palikova, V. A. Palikov, Igor A. Dyachenko, N. A. Borozdina, Oksana Sintsova, V. A. Kazakov, E. N. Kazakova, E. S. Sadovnikova
Publikováno v:
Bulletin of Experimental Biology and Medicine. 172:367-371
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cae2881b9bd4f08300ed45b59a080dc
https://doi.org/10.47056/0365-9615-2021-172-9-367-371
https://doi.org/10.47056/0365-9615-2021-172-9-367-371
Publikováno v:
Biochemistry (Moscow). 86:S50-S70
Although TRPV1 ion channel has been attracting researchers' attention for many years, its functions in animal organisms, the principles of regulation, and the involvement in pathological processes have not yet been fully clarified. Mutagenesis experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2f8bc43ca08220fb6b95996bfc1f7c2
https://doi.org/10.1134/s0006297921140054
https://doi.org/10.1134/s0006297921140054