Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Oksana I. Leszczyszyn"'
Autor:
Markos Trikeriotis, Sergey Akbulatov, Umberto Esposito, Athanasios Anastasiou, Oksana I. Leszczyszyn
Publikováno v:
Pharmaceutical Research. 40:487-500
Purpose Forming accurate data models that assist the design of developability assays is one area that requires a deep and practical understanding of the problem domain. We aim to incorporate expert knowledge into the model building process by creatin
Autor:
Oksana I. Leszczyszyn, John M. Charnock, Claudia A. Blindauer, Stephen R. Stürzenbaum, Mark E. Hodson, Sukaina Zeitoun-Ghandour
Publikováno v:
FEBS Journal. 277:2531-2542
The nematode Caenorhabditis elegans expresses two metallothioneins (MTs), CeMT-1 and CeMT-2, that are believed to be key players in the protection against metal toxicity. In this study, both isoforms were expressed in vitro in the presence of either
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 68:922-935
Early cysteine labeled (E(C)) proteins are plant metallothioneins, which were first identified in wheat embryos and are thought to be seed-specific. An exhaustive analysis of expressed sequence tag (EST) entries reveals that homologs are expressed in
Autor:
Stella E. Keiper, Gemma Z. L. Warren, Claudia A. Blindauer, Oksana I. Leszczyszyn, Christine D. Evans
Publikováno v:
Inorganica Chimica Acta. 360:3-13
The bacterial metallothionein SmtA binds four zinc ions with high affinity and specificity in a Zn4S9N2 cluster. We have explored the reactivity of these zinc ions towards the metal-chelator EDTA. Under pseudo-first-order conditions, initial break-do
Autor:
Stephen R. Stürzenbaum, Claudia A. Blindauer, Sukaina Zeitoun-Ghandour, Oksana I. Leszczyszyn
Publikováno v:
Chem. Commun.. 47:448-450
In vitro evidence for the isoform-specific partitioning of cadmium and zinc ions between the two C. elegans metallothioneins is presented. This observation is discussed in terms of isoform-specific affinities towards zinc and cadmium and the implicat
Publikováno v:
Metallomics : integrated biometal science. 5(9)
More than 30 years have passed since the discovery of the first plant metallothionein in wheat embryos, from which the emergence of a uniquely diverse metallothionein family with a fascinating array of structural nuances and molecular properties has
Publikováno v:
ChemInform. 41
Covering: 1999 to 2009 Metallothioneins have been the subject of intense study for five decades, and have greatly inspired the development of bio-analytical methodologies including multi-dimensional and multi-nuclear NMR. With further advancements in
Autor:
Sukaina, Zeitoun-Ghandour, John M, Charnock, Mark E, Hodson, Oksana I, Leszczyszyn, Claudia A, Blindauer, Stephen R, Stürzenbaum
Publikováno v:
The FEBS journal. 277(11)
The nematode Caenorhabditis elegans expresses two metallothioneins (MTs), CeMT-1 and CeMT-2, that are believed to be key players in the protection against metal toxicity. In this study, both isoforms were expressed in vitro in the presence of either
Publikováno v:
Molecular bioSystems. 6(9)
The selectivity of proteins involved in metal ion homeostasis is an important part of the puzzle to understand how cells allocate the correct metal ions to the correct proteins. Due to their similar ligand-binding properties, and their frequent co-ex
Autor:
Oksana I. Leszczyszyn, Claudia A. Blindauer, Florian M. Geier, Stephen R. Stürzenbaum, Jacob G. Bundy, Sukaina Zeitoun-Ghandour
Publikováno v:
Molecular BioSystems. 7:2397
The genome of the nematode Caenorhabditis elegans encodes for two multifunctional metal binding metallothioneins (MTs), CeMT-1 and CeMT-2. Here we applied qPCR to identify a transcriptional up-regulation following the exposure to free radical generat