Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Oksana Berezovska"'
Autor:
Steven S Hou, Yuya Ikegawa, Yeseo Kwon, Natalia Wieckiewicz, Mei CQ Houser, Brianna Lundin, Brian J Bacskai, Oksana Berezovska, Masato Maesako
Publikováno v:
eLife, Vol 13 (2024)
γ-Secretase plays a pivotal role in the central nervous system. Our recent development of genetically encoded Förster resonance energy transfer (FRET)-based biosensors has enabled the spatiotemporal recording of γ-secretase activity on a cell-by-c
Externí odkaz:
https://doaj.org/article/ff11a7dff0964b278922b4ba3c0fa4b1
Autor:
Katarzyna Marta Zoltowska, Utpal Das, Sam Lismont, Thomas Enzlein, Masato Maesako, Mei CQ Houser, Maria Luisa Franco, Burcu Özcan, Diana Gomes Moreira, Dmitry Karachentsev, Ann Becker, Carsten Hopf, Marçal Vilar, Oksana Berezovska, William Mobley, Lucía Chávez-Gutiérrez
Publikováno v:
eLife, Vol 12 (2024)
Amyloid β (Aβ) peptides accumulating in the brain are proposed to trigger Alzheimer’s disease (AD). However, molecular cascades underlying their toxicity are poorly defined. Here, we explored a novel hypothesis for Aβ42 toxicity that arises from
Externí odkaz:
https://doaj.org/article/2631ca395939430b962c9f2eb0249faf
Autor:
Priyanka Sinha, Yuliia Turchyna, Shane Patrick Clancy Mitchell, Michael Sadek, Gokce Armagan, Florian Perrin, Masato Maesako, Oksana Berezovska
Publikováno v:
Cells, Vol 13, Iss 19, p 1600 (2024)
Glutamate transporter-1 (GLT-1) dynamics are implicated in excitotoxicity and Alzheimer’s disease (AD) progression. Early stages of AD are often marked by hyperactivity and increased epileptiform activity preceding cognitive decline. Previously, we
Externí odkaz:
https://doaj.org/article/3969f56997554ee5b81d014eef26075a
Autor:
Evangelos Konstantinidis, Agnieszka Molisak, Florian Perrin, Linn Streubel-Gallasch, Sarah Fayad, Daniel Y. Kim, Karl Petri, Martin J. Aryee, Ximena Aguilar, Bence György, Vilmantas Giedraitis, J. Keith Joung, Vikram Pattanayak, Magnus Essand, Anna Erlandsson, Oksana Berezovska, Martin Ingelsson
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 450-461 (2022)
Presenilin 1 (PS1) is a central component of γ-secretase, an enzymatic complex involved in the generation of the amyloid-β (Aβ) peptide that deposits as plaques in the Alzheimer’s disease (AD) brain. The M146L mutation in the PS1 gene (PSEN1) le
Externí odkaz:
https://doaj.org/article/503c1c5367834e719f03a069aa99c40b
Autor:
Mei C. Q. Houser, Shane P. C. Mitchell, Priyanka Sinha, Brianna Lundin, Oksana Berezovska, Masato Maesako
Publikováno v:
Sensors, Vol 23, Iss 5, p 2651 (2023)
Our unique multiplexed imaging assays employing FRET biosensors have previously detected that γ-secretase processes APP C99 primarily in late endosomes and lysosomes in live/intact neurons. Moreover we have shown that Aβ peptides are enriched in th
Externí odkaz:
https://doaj.org/article/feff77a0dfd94dfb90e66cb1b7edaf28
Autor:
Alec K. McKendell, Mei C. Q. Houser, Shane P. C. Mitchell, Michael S. Wolfe, Oksana Berezovska, Masato Maesako
Publikováno v:
Biosensors, Vol 12, Iss 8, p 663 (2022)
Amyloid-beta (Aβ) peptides are produced within neurons. Some peptides are released into the brain parenchyma, while others are retained inside the neurons. However, the detection of intracellular Aβ remains a challenge since antibodies against Aβ
Externí odkaz:
https://doaj.org/article/fd9e8fa427f84466aa0ca2ba63adb949
Autor:
Masato Maesako, Nicole M. Sekula, Anna Aristarkhova, Polina Feschenko, Lauren C. Anderson, Oksana Berezovska
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101139- (2020)
Summary: A change in Presenilin (PS)/γ-secretase activity is linked to essential biological events as well as to the progression of many diseases. However, not much is known about how PS/γ-secretase activity is spatiotemporally regulated in cells.
Externí odkaz:
https://doaj.org/article/6a2fba5afd814e7ab312c1cf43d7c2b6
Autor:
Mei C. Q. Houser, Yuliia Turchyna, Florian Perrin, Lori Chibnik, Oksana Berezovska, Masato Maesako
Publikováno v:
Biosensors, Vol 11, Iss 6, p 169 (2021)
Presenilin (PS)/γ-secretase is an aspartyl protease that processes a wide range of transmembrane proteins such as the amyloid precursor protein (APP) and Notch1, playing essential roles in normal biological events and diseases. However, whether ther
Externí odkaz:
https://doaj.org/article/a33e9e7e9c9540cf8abd6d6be3653847
Autor:
Frank Raven, Joseph F. Ward, Katarzyna M. Zoltowska, Yu Wan, Enjana Bylykbashi, Sean J. Miller, Xunuo Shen, Se Hoon Choi, Kevin D. Rynearson, Oksana Berezovska, Steven L. Wagner, Rudolph E. Tanzi, Can Zhang
Publikováno v:
EBioMedicine, Vol 24, Iss C, Pp 93-101 (2017)
A central pathogenic event of Alzheimer's disease (AD) is the accumulation of the Aβ42 peptide, which is generated from amyloid-β precursor protein (APP) via cleavages by β- and γ-secretase. We have developed a class of soluble 2-aminothiazole γ
Externí odkaz:
https://doaj.org/article/8a8ad0d1c493496387f9e9c4027a02a7
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226368 (2019)
It has been revealed that β-amyloid (Aβ) is generated and released from the presynaptic terminals in activity-dependent manner. However, molecules modulating the presynaptic Aβ generation remain elusive. Here we test the hypothesis that Synapsin 1
Externí odkaz:
https://doaj.org/article/1f425d3733cc405c8b4b7712d44d3755