Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Oksana, Shynlova"'
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0297847 (2024)
The uterine muscular layer, or myometrium, undergoes profound changes in global gene expression during its progression from a quiescent state during pregnancy to a contractile state at the onset of labor. In this study, we investigate the role of SOX
Externí odkaz:
https://doaj.org/article/d9f66f9ca31f451081adf56211694d94
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0271081 (2023)
Spontaneous uterine contractions are initiated when smooth muscle cells (SMCs) within the uterine muscle, or myometrium, transition from a functionally dormant to an actively contractile phenotype at the end of the pregnancy period. We know that this
Externí odkaz:
https://doaj.org/article/30299aa98be2435d8e6759479db11914
Autor:
Antara Chatterjee, Rojan Saghian, Anna Dorogin, Lindsay S. Cahill, John G. Sled, Stephen Lye, Oksana Shynlova
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract The cervix is responsible for maintaining pregnancy, and its timely remodeling is essential for the proper delivery of a baby. Cervical insufficiency, or “weakness”, may lead to preterm birth, which causes infant morbidities and mortalit
Externí odkaz:
https://doaj.org/article/7f7f92da7b084b499d328e58cdfe9ed9
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Abstract Preterm birth (PTB) is a multifactorial syndrome affecting millions of neonates worldwide. Intrauterine infection can induce PTB through the secretion of pro-inflammatory cytokines and untimely activation of uterine contractions. In pregnant
Externí odkaz:
https://doaj.org/article/7787bd88bc434e018b5ce6375e38ae9f
Publikováno v:
EBioMedicine, Vol 39, Iss , Pp 531-539 (2019)
Background: Decidual natural killer (dNK) cells are the predominant lymphocytes accumulated at the maternal-fetal interface. Regulatory mechanism of dNK cells in preeclampsia, a gestational complication characterized by high blood pressure and increa
Externí odkaz:
https://doaj.org/article/dad2fa54c593493393c4c5142f582d85
Autor:
Virlana M Shchuka, Luis E Abatti, Huayun Hou, Nawrah Khader, Anna Dorogin, Michael D Wilson, Oksana Shynlova, Jennifer A Mitchell
Publikováno v:
PLoS Biology, Vol 18, Iss 7, p e3000710 (2020)
During gestation, uterine smooth muscle cells transition from a state of quiescence to one of contractility, but the molecular mechanisms underlying this transition at a genomic level are not well-known. To better understand these events, we evaluate
Externí odkaz:
https://doaj.org/article/0d7f135a0a884ad281c49325f3d0ca50
Autor:
Michelle Coleman, Austyn Orvis, Tsung-Yen Wu, Matthew Dacanay, Sean Merillat, Jason Ogle, Audrey Baldessari, Nicole M. Kretzer, Jeff Munson, Adam J. Boros-Rausch, Oksana Shynlova, Stephen Lye, Lakshmi Rajagopal, Kristina M. Adams Waldorf
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Leukocyte activation within the chorioamniotic membranes is strongly associated with inflammation and preterm labor (PTL). We hypothesized that prophylaxis with a broad-spectrum chemokine inhibitor (BSCI) would downregulate the inflammatory microenvi
Externí odkaz:
https://doaj.org/article/619350db505e447abea1a049a5ff98a9
Publikováno v:
Cells, Vol 11, Iss 1, p 128 (2021)
Prophylactic administration of the broad-spectrum chemokine inhibitor (BSCI) FX125L has been shown to suppress uterine contraction, prevent preterm birth (PTB) induced by Group B Streptococcus in nonhuman primates, and inhibit uterine cytokine/chemok
Externí odkaz:
https://doaj.org/article/4085030da0cc4ee7a6f272259e0f8358
Autor:
Marianna Alperin, Steven Abramowitch, May Alarab, Maria Bortolini, Bryan Brown, Lindsey A. Burnett, Kathleen A. Connell, Margot Damaser, Raffaella de Vita, Caroline E. Gargett, Marsha K. Guess, Zeliha Guler, Renato Natal Jorge, Robert S. Kelley, Mark Kibschull, Kristin Miller, Pamela A. Moalli, Indira U. Mysorekar, Megan R. Routzong, Oksana Shynlova, Carolyn W. Swenson, Marrisa A. Therriault, Gina M. Northington
Publikováno v:
Int Urogynecol J
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e5027b19caf783ae37f513dbcf7e087
https://doi.org/10.1007/s00192-022-05253-y
https://doi.org/10.1007/s00192-022-05253-y
Autor:
Lubna Nadeem, Oksana Shynlova, Elzbieta Matysiak-Zablocki, Sam Mesiano, Xuesen Dong, Stephen Lye
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
How human labour is initiated in the presence of high circulating progesterone is still unclear. Here, the authors show that during a reduction in myometrial nuclear progesterone levels, there is an increased transcription of the key labour gene, Cx4
Externí odkaz:
https://doaj.org/article/a9cbb860df8546a38946568c449db560