Discovery of Pyrazolopyrazines as Selective, Potent, and Mutant-Active MET Inhibitors with Intracranial Efficacy.

Autor: Bumpers QA; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Pipal RW; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Benz-Weeden AM; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Brewster JT 2nd; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Cook A; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Crooks AL; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Cruz C; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Dwulet NC; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Gaudino JJ; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Golec D; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Harrison JA; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Hartley DP; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Hassanien SH; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Hicken EJ; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Kahn D; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Laird ER; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Lemieux C; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Lewandowski N; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., McCown J; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., McDonald MG; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., McNulty O; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Mou TC; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Nguyen P; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Oko L; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Opie LP; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Otten J; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Peck SC; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Polites VC; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Randall SD; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Rosen RZ; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Savechenkov P; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Simpson H; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Singh A; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Sparks D; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Wickersham K; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Wollenberg L; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Wong CE; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Wong J; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Wu WI; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Elsayed MSA; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Hinklin RJ; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States., Tang TP; Pfizer Research & Development 3200 Walnut Street, Boulder, Colorado 80301, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Aug 22; Vol. 67 (16), pp. 14466-14477. Date of Electronic Publication: 2024 Aug 01.

Azadirachta indica A. Juss bark extract and its Nimbin isomers restrict β-coronaviral infection and replication.

Autor: Sarkar L; Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, Nadia, India., Oko L; Department of Neurology, University of Colorado School of Medicine, Aurora, CO, 80045, USA., Gupta S; The Systems Virology Lab, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden., Bubak AN; Department of Neurology, University of Colorado School of Medicine, Aurora, CO, 80045, USA., Das B; Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, Nadia, India., Gupta P; Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, Nadia, India., Safiriyu AA; Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, Nadia, India., Singhal C; Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, Nadia, India., Neogi U; The Systems Virology Lab, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden., Bloom D; Department of Molecular Genetics and Microbiology, University of Florida College of Medicine, Gainesville, FL, USA., Banerjee A; Laboratory of Virology, Regional Centre for Biotechnology, and Translational Health Science & Technology Institute Faridabad, Haryana, India., Mahalingam R; Department of Neurology, University of Colorado School of Medicine, Aurora, CO, 80045, USA., Cohrs RJ; Department of Neurology, University of Colorado School of Medicine, Aurora, CO, 80045, USA., Koval M; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, 30322, USA., Shindler KS; Departments of Ophthalmology and Neurology, University of Pennsylvania, Scheie Eye Institute, Philadelphia, PA, USA., Pal D; Department of Computational and Data Sciences, Indian Institute of Science, Bangalore Karnataka, 560012, India., Nagel M; Department of Neurology, University of Colorado School of Medicine, Aurora, CO, 80045, USA., Sarma JD; Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, Nadia, India; Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: dassarmaj@iiserkol.ac.in.

Publikováno v: Virology [Virology] 2022 Apr; Vol. 569, pp. 13-28. Date of Electronic Publication: 2022 Feb 15.

Attenuating Mutations in nsP1 Reveal Tissue-Specific Mechanisms for Control of Ross River Virus Infection

Autor: Gunn, B. M., Jupille, H. J., Hawman, D. W., Long, K. M., Morrison, T. E., Oko, L., Minor, M., Stoermer Burrack, K. A., Shives, K. D.

Ross River virus (RRV) is one of a group of mosquito-transmitted alphaviruses that cause debilitating, and often chronic, musculoskeletal disease in humans. Previously, we reported that replacement of the nonstructural protein 1 (nsP1) gene of the mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::484e008939235b0261156cdf24e6374d

Analyzing the Immunomodulatory Effects of Tea PolyPhenols and in management of COVID-19.

Autor: Verma, Tanishque¹, Kumar Mishra, Rudra Awdhesh¹, Easwaran, Nalini¹, Muthukaliannan, Gothandam Kodiveri¹ gothandam@gmail.com

Publikováno v: Current Trends in Biotechnology & Pharmacy. Oct2024, Vol. 18 Issue 4, p1999-2014. 16p.

Building a human lung from pluripotent stem cells to model respiratory viral infections.

Autor: Turner, Declan L.^1,2,3 (AUTHOR), Amoozadeh, Sahel^1,2,3 (AUTHOR), Baric, Hannah^1,2,3 (AUTHOR), Stanley, Ed^1,2,3 (AUTHOR), Werder, Rhiannon B.^1,2,3 (AUTHOR) rhiannon.werder@mcri.edu.au

Publikováno v: Respiratory Research. 7/15/2024, Vol. 25 Issue 1, p1-20. 20p.