Zobrazeno 1 - 10
of 349
pro vyhledávání: '"Okio Hino"'
Autor:
Yu Koyama, Hiroya Okazaki, Yang Shi, Yoshihiro Mezawa, Zixu Wang, Mizuki Sakimoto, Akane Ishizuka, Yasuhiko Ito, Takumi Koyama, Yataro Daigo, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Keisuke Sugahara, Okio Hino, Liying Yang, Reo Maruyama, Akira Katakura, Takehiro Yasukawa, Akira Orimo
Publikováno v:
Cancer Medicine, Vol 12, Iss 17, Pp 18062-18077 (2023)
Abstract Background Cancer‐associated fibroblasts (CAFs) are a major stromal component of human breast cancers and often promote tumor proliferation, progression and malignancy. We previously established an experimental CAF (exp‐CAF) cell line eq
Externí odkaz:
https://doaj.org/article/96ae5b868f724f33af3c3e73ed1001ff
Autor:
Hirofumi Kashii, Shinya Kasai, Atsushi Sato, Yoko Hagino, Yasumasa Nishito, Toshiyuki Kobayashi, Okio Hino, Masashi Mizuguchi, Kazutaka Ikeda
Publikováno v:
Human Genomics, Vol 17, Iss 1, Pp 1-13 (2023)
Abstract Background Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that is associated with neurological symptoms, including autism spectrum disorder. Tuberous sclerosis complex is caused by pathogenic germline mutations of either
Externí odkaz:
https://doaj.org/article/a39b296936a646239a528d815f67eade
Autor:
Tadaaki Inano, Hajime Yasuda, Yutaka Tsukune, Miyuki Tsutsui, Nadila Wali, Harumi Saeki, Kazunori Kajino, Okio Hino, Yasufumi Masaki, Norio Komatsu
Publikováno v:
Case Reports in Oncology, Vol 15, Iss 1, Pp 7-11 (2022)
TAFRO syndrome is a relatively new disease entity first reported in 2010. We report a case of TAFRO syndrome accommodated by abnormal exacerbation of moderately differentiated gastric adenocarcinoma. The pathophysiology of TAFRO syndrome is largely u
Externí odkaz:
https://doaj.org/article/81d3b577c4334051b5dc92c9fa622d6c
Autor:
Bo Han, Hyeon‐Cheol Lee‐Okada, Momoko Ishimine, Hajime Orita, Keiko Nishikawa, Tetsuya Takagaki, Kazunori Kajino, Takehiko Yokomizo, Okio Hino, Toshiyuki Kobayashi
Publikováno v:
FEBS Open Bio, Vol 10, Iss 11, Pp 2375-2387 (2020)
Malignant mesothelioma (MM) is an aggressive malignant neoplasm which rapidly invades pleural tissues and has a poor prognosis. Here, we explore enhancement of the effect of irinotecan [camptothecin‐11 (CPT‐11)] by the p53‐dependent induction o
Externí odkaz:
https://doaj.org/article/95ef359e025a429ea89d075c8971ea0a
Autor:
Masataka Kojima, Kazunori Kajino, Shuji Momose, Nadila Wali, May Thinzar Hlaing, Bo Han, Liang Yue, Masaaki Abe, Tomoaki Fujii, Katsuhisa Ikeda, Okio Hino
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-11 (2020)
Abstract Background Mesothelioma is histologically divided into three subgroups: epithelioid, sarcomatoid, and biphasic types. The epithelioid or sarcomatoid type is morphologically defined by polygonal or spindle-like forms of cells, respectively. T
Externí odkaz:
https://doaj.org/article/82efa4384deb4481b5575811406a21b4
Autor:
Yoshitomo Hamano, Fuyu Ito, Osamu Suzuki, Minako Koura, Shuji Matsuoka, Toshiyuki Kobayashi, Yoshinobu Sugitani, Nadila Wali, Ai Koyanagi, Okio Hino, Shoichi Suzuki, Ryuichi Sugamata, Hiromichi Yoshizawa, Wako Yumura, Naoki Maruyama, Yosuke Kameoka, Yoshihiro Noda, Yasuko Hasegawa, Tomio Arai, Kazuo Suzuki
Publikováno v:
Autoimmunity, Vol 52, Iss 5-6, Pp 208-219 (2019)
Lupus nephritis (LN) is the secondary glomerulonephritis (GN) involved in systemic lupus erythematosus (SLE) and a typical immune complex-type GN. Antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is an autoimmune disease cha
Externí odkaz:
https://doaj.org/article/c5f3a97726434216bf49c6f8ddfda190
Autor:
Yoshihiro Mezawa, Yataro Daigo, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Chikao Morimoto, Okio Hino, Akira Orimo
Publikováno v:
Cancer Medicine, Vol 8, Iss 8, Pp 3936-3948 (2019)
Abstract Human breast carcinoma‐associated fibroblasts (CAFs) increasingly acquire both transforming growth factor‐β (TGF‐β) and stromal cell‐derived factor‐1 (SDF‐1) signaling in an autocrine fashion during tumor progression. Such sign
Externí odkaz:
https://doaj.org/article/3cb462969a8e43af962fd30472279db1
Autor:
Shuji Matsuoka, Yasuyuki Ishii, Atsuhito Nakao, Masaaki Abe, Naomi Ohtsuji, Shuji Momose, Hui Jin, Hisashi Arase, Koichi Sugimoto, Yusuke Nakauchi, Hiroshi Masutani, Michiyuki Maeda, Hideo Yagita, Norio Komatsu, Okio Hino
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150496 (2016)
To develop a new therapeutic monoclonal Antibody (mAb) for Hodgkin lymphoma (HL), we immunized a BALB/c mouse with live HL cell lines, alternating between two HL cell lines. After hybridization, we screened the hybridoma clones by assessing direct cy
Externí odkaz:
https://doaj.org/article/d364300c7b7948fdb551b743738da2ba
Autor:
Katsumi Fukamachi, Masaaki Iigo, Yoshiaki Hagiwara, Koji Shibata, Mitsuru Futakuchi, David B Alexander, Okio Hino, Masumi Suzui, Hiroyuki Tsuda
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111481 (2014)
Pancreatic ductal adenocarcinoma (PDA) is a highly lethal disease, which is usually diagnosed in an advanced stage. We have established transgenic rats carrying a mutated K-ras gene controlled by Cre/loxP activation. The animals develop PDA which is
Externí odkaz:
https://doaj.org/article/ddd7ed4e5d06403b87338e8ccd9ba5ef
Autor:
Maki Ohsawa, Toshiyuki Kobayashi, Hidehiro Okura, Takashi Igarashi, Masashi Mizuguchi, Okio Hino
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54503 (2013)
The tumor-suppressor genes TSC1 and TSC2 are mutated in tuberous sclerosis, an autosomal dominant multisystem disorder. The gene products of TSC1 and TSC2 form a protein complex that inhibits the signaling of the mammalian target of rapamycin complex
Externí odkaz:
https://doaj.org/article/cf43953a82e54fbfa932899f9e265d01