Selective Inhibition of ICAM-1 and E-Selectin Expression in Human Endothelial Cells. 2. Aryl Modifications of 4-(Aryloxy)thieno[2,3-c]pyridines with Fine-Tuning at C-2 Carbamides

Autor: Zhu, G.-D., Arendsen, D. L., Gunawardana, I. W., Boyd, S. A., Stewart, A. O., Fry, D. G., Cool, B. L., Kifle, L., Schaefer, V., Meuth, J., Marsh, K. C., Kempf-Grote, A. J., Kilgannon, P., Gallatin, W. M., Okasinski, G. F.

Publikováno v: Journal of Medicinal Chemistry; October 2001, Vol. 44 Issue: 21 p3469-3487, 19p

Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 2. Mechanism of Inhibition and Structure-Based Improvement of Pharmaceutical Properties

Autor: Liu, G., Huth, J. R., Olejniczak, E. T., Mendoza, R., DeVries, P., Leitza, S., Reilly, E. B., Okasinski, G. F., Fesik, S. W., Geldern, T. W. von

Publikováno v: Journal of Medicinal Chemistry; April 2001, Vol. 44 Issue: 8 p1202-1210, 9p

Discovery of Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 1. Identification of an Additional Binding Pocket Based on an Anilino Diaryl Sulfide Lead

Autor: Liu, G., Link, J. T., Pei, Z., Reilly, E. B., Leitza, S., Nguyen, B., Marsh, K. C., Okasinski, G. F., Geldern, T. W. von, Ormes, M., Fowler, K., Gallatin, M.

Publikováno v: Journal of Medicinal Chemistry; October 19, 2000, Vol. 43 Issue: 21 p4025-4040, 16p

Analysis of intracellular feline leukemia virus proteins II. Generation of feline leukemia virus structural proteins from precursor polypeptides

Autor: Okasinski, G F, Velicer, L F

Publikováno v: The Journal of Virology; April 1977, Vol. 22 Issue: 1 p74-85, 12p

Discovery of potent antagonists of leukocyte function-associated antigen-1/intercellular adhesion molecule-1 interaction. 3. Amide (C-ring) structure-activity relationship and improvement of overall properties of arylthio cinnamides.

Autor: Pei Z; Department of Metabolic Disease Research, Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois 60064, USA. zhonghua.pei@abbott.com, Xin Z, Liu G, Li Y, Reilly EB, Lubbers NL, Huth JR, Link JT, von Geldern TW, Cox BF, Leitza S, Gao Y, Marsh KC, DeVries P, Okasinski GF

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2001 Aug 30; Vol. 44 (18), pp. 2913-20.