Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Ok-Seon Kwon"'
Publikováno v:
Stem Cell Research, Vol 65, Iss , Pp 102950- (2022)
Given the advantage of being able to be extracted by a minimally invasive method, blood is regarded as a suitable cell source for reprogramming to establish induced pluripotent stem cells (iPSCs). Therefore, iPSCs established from patient derived per
Externí odkaz:
https://doaj.org/article/63aa25aca5044de6a4b9f44e82e3535a
Publikováno v:
Molecular Oncology, Vol 15, Iss 2, Pp 679-696 (2021)
The acquisition of chemoresistance remains a major cause of cancer mortality due to the limited accessibility of targeted or immune therapies. However, given that severe alterations of molecular features during epithelial‐to‐mesenchymal transitio
Externí odkaz:
https://doaj.org/article/34b15c9e56bc4925bbe359f4f2330c65
Autor:
Soon-Ki Hong, Haeseung Lee, Ok-Seon Kwon, Na-Young Song, Hyo-Ju Lee, Seungmin Kang, Jeong-Hwan Kim, Mirang Kim, Wankyu Kim, Hyuk-Jin Cha
Publikováno v:
Molecular Cancer, Vol 17, Iss 1, Pp 1-7 (2018)
Abstract Even when targets responsible for chemoresistance are identified, drug development is often hampered due to the poor druggability of these proteins. We systematically analyzed therapy-resistance with a large-scale cancer cell transcriptome a
Externí odkaz:
https://doaj.org/article/fe9f31f955e54799840c26ecbf0213d0
Autor:
Ok-Seon Kwon, Eun-Ji Kwon, Hyeon-Joon Kong, Jeong-Yoon Choi, Yun-Jeong Kim, Eun-Woo Lee, Wankyu Kim, Haeseung Lee, Hyuk-Jin Cha
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101719- (2020)
Erastin, a synthetic lethal compound against cancer expressing an oncogenic RAS, inhibits cystine/glutamate antiporters and causes ferroptosis. However, despite recent evidence for the mechanisms underlying ferroptosis, molecular biomarkers of erasti
Externí odkaz:
https://doaj.org/article/9f43a3232f5943e0bce94ef45fafad38
Autor:
Seung-Ju Cho, Keun-Tae Kim, Ho-Chang Jeong, Ju-Chan Park, Ok-Seon Kwon, Yun-Ho Song, Joong-Gon Shin, Seungmin Kang, Wankyu Kim, Hyoung Doo Shin, Mi-Ok Lee, Sung-Hwan Moon, Hyuk-Jin Cha
Publikováno v:
Stem Cell Reports, Vol 11, Iss 5, Pp 1244-1256 (2018)
Summary: The selective survival advantage of culture-adapted human embryonic stem cells (hESCs) is a serious safety concern for their clinical application. With a set of hESCs with various passage numbers, we observed that a subpopulation of hESCs at
Externí odkaz:
https://doaj.org/article/592605e5a71c47feab63b767afa74cf0
Autor:
Young-Hyun Go, Changjin Lim, Ho-Chang Jeong, Ok-Seon Kwon, Sungkyun Chung, Haeseung Lee, Wankyu Kim, Young-Ger Suh, Woo Sung Son, Mi-Ok Lee, Hyuk-Jin Cha, Seok-Ho Kim
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
Despite great potential for regenerative medicine, the high tumorigenic potential of human pluripotent stem cells (hPSCs) to form undesirable teratoma is an important technical hurdle preventing safe cell therapy. Various small molecules that induce
Externí odkaz:
https://doaj.org/article/6494ba0c258f42d4b5b4cbe7dc525f06
Autor:
Young-Hyun Go, Hyo-Ju Lee, Hyeon-Joon Kong, Ho-Chang Jeong, Dong Young Lee, Soon-Ki Hong, Sang Hyun Sung, Ok-Seon Kwon, Hyuk-Jin Cha
Publikováno v:
Royal Society Open Science, Vol 5, Iss 12 (2018)
The Fluorescent Ubiquitination-based Cell Cycle Indicator (FUCCI) system can be used not only to study gene expression at a specific cell cycle stage, but also to monitor cell cycle transitions in real time. In this study, we used a single clone of F
Externí odkaz:
https://doaj.org/article/73015de21a2a450c8ff0cd08a0c04f00
Autor:
Ok-Seon Kwon, Keun-Tae Kim, Eunioo Lee, Myoungjae Kim, Seo-Hyun Choi, Henghong Li, Albert J Fornace, Jae-Ho Cho, Yun-Sil Lee, Ji-Seon Lee, Yoon-Jin Lee, Hyuk-Jin Cha
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154942 (2016)
Radiation-induced lung fibrosis, the most serious effect of lung cancer radiotherapy on normal tissue, remains a major technical obstacle to the broader application of radiotherapy to patients with lung cancer. This study describes the use of an imag
Externí odkaz:
https://doaj.org/article/b04a771e4a984e25897b6ddaed92eefb
Autor:
Ho‐Joon Lee, Seon Ju Mun, Cho‐Rok Jung, Hyun‐Mi Kang, Jae‐Eun Kwon, Jae‐Sung Ryu, Hyo‐Suk Ahn, Ok‐Seon Kwon, Jiwon Ahn, Kyung‐Sik Moon, Myung Jin Son, Kyung‐Sook Chung
Publikováno v:
Biotechnology and Bioengineering. 120:1241-1253
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee12ff633fe90753d00256e00c31c04c
https://doi.org/10.1002/bit.28333
https://doi.org/10.1002/bit.28333
Publikováno v:
Molecular Oncology, Vol 15, Iss 2, Pp 679-696 (2021)
Molecular Oncology
Molecular Oncology
Through integration of multiple large database, two oncogenic signatures (YAP conserved and TGFβ‐up signatures) were commonly upregulated in the cancer cell lines with the mesenchymal properties. AXL, the expression of which is highly induced in E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a5f4f3bfb8b236c1ae2e38c5ec5d7a
https://doaj.org/article/34b15c9e56bc4925bbe359f4f2330c65
https://doaj.org/article/34b15c9e56bc4925bbe359f4f2330c65