Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Ok-Ho Shin"'
Autor:
Ok-Ho, Shin, Ege T, Kavalali
Publikováno v:
The Journal of Cell Biology
Li et al. identify SNT-1 and SNT-3 as the primary and secondary Ca2+ sensors that trigger Ca2+-dependent exocytosis of synaptic vesicles at the Caenorhabditis elegans neuromuscular junction. These two Ca2+ sensors display differential domain structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1305433872a149e518f2eb0be28e9530
https://pubmed.ncbi.nlm.nih.gov/33570571
https://pubmed.ncbi.nlm.nih.gov/33570571
Autor:
Lisa M. Monteggia, Rong Sun, Ok-Ho Shin, Pei-Yi Lin, K Ian White, Baris Alten, Qiangjun Zhou, Axel T. Brunger, Ege T. Kavalali, Luis Esquivies, Wendy K. Chung
Publikováno v:
Neuron. 109(1)
SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptor) complex, composed of synaptobrevin, syntaxin, and SNAP25, forms the essential fusion machinery for neurotransmitter release. Recent studies have reported several mutations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc60365e64b9b94698f8b796b9ca85f2
https://pubmed.ncbi.nlm.nih.gov/33412092
https://pubmed.ncbi.nlm.nih.gov/33412092
Autor:
Natali L, Chanaday, Elena, Nosyreva, Ok-Ho, Shin, Hua, Zhang, Iltan, Aklan, Deniz, Atasoy, Ilya, Bezprozvanny, Ege T, Kavalali
Publikováno v:
Neuron
Store operated calcium entry (SOCE) is activated by depletion of Ca(2+) from the endoplasmic reticulum (ER) and mediated by stromal interaction molecule (STIM) proteins. Here, we show that in rat and mouse hippocampal neurons acute ER Ca(2+) depletio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::edfd360742ff9493b257cfbc2e788d33
https://pubmed.ncbi.nlm.nih.gov/33711258
https://pubmed.ncbi.nlm.nih.gov/33711258
Autor:
Mingshan Xue, Timothy K Craig, Ok-Ho Shin, Liyi Li, Chad A Brautigam, Diana R Tomchick, Thomas C Südhof, Christian Rosenmund, Josep Rizo
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
Synaptotagmins are known to mediate diverse forms of Ca2+-triggered exocytosis through their C2 domains, but the principles underlying functional differentiation among them are unclear. Synaptotagmin-1 functions as a Ca2+ sensor in neurotransmitter r
Externí odkaz:
https://doaj.org/article/1a0e4ff6bc3e445b8dcdc1a1a5cc2c74
Autor:
Ege T. Kavalali, Deniz Atasoy, Natali L. Chanaday, Hua Zhang, İltan Aklan, Ilya Bezprozvanny, Ok Ho Shin, Elena Nosyreva
Publikováno v:
Neuron. 109:1314-1332.e5
Store-operated calcium entry (SOCE) is activated by depletion of Ca2+ from the endoplasmic reticulum (ER) and mediated by stromal interaction molecule (STIM) proteins. Here, we show that in rat and mouse hippocampal neurons, acute ER Ca2+ depletion i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a2199a4a95b9c97fe684538551891cc
https://doi.org/10.1016/j.neuron.2021.02.023
https://doi.org/10.1016/j.neuron.2021.02.023
Autor:
Ok-Ho Shin1, Jun Lu1, Jeong-Seop Rhee1, Tomchick, Diana R.2, Pang, Zhiping P.3,4, Wojcik, Sonja M.5, Camacho-Perez, Marcial6,7, Brose, Nils5, Machius, Mischa2, Rizo, Josep2,8 jose@arnie.swmed.edu, Rosenmund, Christian6,8,9 rosenmun@bcm.tmc.edu, Südhof, Thomas C.3,4,10,11,12 tcs1@stanford.edu
Publikováno v:
Nature Structural & Molecular Biology. Mar2010, Vol. 17 Issue 3, p280-288. 9p. 2 Diagrams, 1 Chart, 5 Graphs.
Autor:
Han Dai1,2, Ok-Ho Shin3,4,5, Machius, Mischa1, Tomchick, Diana R.1, Südhof, Thomas C .3,4,5, Rizo, Josep1,2 jose@arnie.swmed.edu
Publikováno v:
Nature Structural & Molecular Biology. Sep2004, Vol. 11 Issue 9, p844-849. 6p.
Autor:
Alvin M. Shih, Ok Ho Shin
Publikováno v:
Analytical Biochemistry. 416:107-111
Exocytosis is one of the most crucial and ubiquitous processes in all of biology. This event is mediated by the formation of SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complexes, ternary assemblies of syntaxin, SNAP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e1d245c2f9c3c52ff5bd3bc5626229a
https://doi.org/10.1016/j.ab.2011.05.010
https://doi.org/10.1016/j.ab.2011.05.010
Autor:
Thomas C. Südhof, Jeong-Seop Rhee, Ok Ho Shin, Diana R. Tomchick, Christian Rosenmund, Sonja M. Wojcik, Nils Brose, Marcial Camacho-Perez, Josep Rizo, Jun Lu, Zhiping P. Pang, Mischa Machius
Publikováno v:
Nature structural & molecular biology
Munc13 is a multidomain protein present in presynaptic active zones that mediates the priming and plasticity of synaptic vesicle exocytosis, but the mechanisms involved remain unclear. Here we use biophysical, biochemical and electrophysiological app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0fbaa8c8d54d649a793cf049218d78
http://europepmc.org/articles/PMC2916016
http://europepmc.org/articles/PMC2916016
Publikováno v:
Proceedings of the National Academy of Sciences. 106:16469-16474
Neurotransmitter release is triggered by cooperative Ca 2+ -binding to the Ca 2+ -sensor protein synaptotagmin-1. Synaptotagmin-1 contains two C2 domains, referred to as the C2A and C2B domains, that bind Ca 2+ with similar properties and affinities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38dc78274410199ea3419c5a8527d0ac
https://doi.org/10.1073/pnas.0908798106
https://doi.org/10.1073/pnas.0908798106