Astrocyte-derived MFG-E8 facilitates microglial synapse elimination in Alzheimer's disease mouse models.

Autor: Sokolova D; UK Dementia Research Institute, Institute of Neurology, University College London, Gower Street, London, WC1E 6BT, United Kingdom.; Neuroscience BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom., Ghansah SA; UK Dementia Research Institute, Institute of Neurology, University College London, Gower Street, London, WC1E 6BT, United Kingdom., Puletti F; UK Dementia Research Institute, Institute of Neurology, University College London, Gower Street, London, WC1E 6BT, United Kingdom., Georgiades T; UK Dementia Research Institute, Institute of Neurology, University College London, Gower Street, London, WC1E 6BT, United Kingdom., De Schepper S; UK Dementia Research Institute, Institute of Neurology, University College London, Gower Street, London, WC1E 6BT, United Kingdom., Zheng Y; UK Dementia Research Institute, Institute of Neurology, University College London, Gower Street, London, WC1E 6BT, United Kingdom., Crowley G; UK Dementia Research Institute, Institute of Neurology, University College London, Gower Street, London, WC1E 6BT, United Kingdom., Wu L; Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1751, USA; Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1751, USA., Rueda-Carrasco J; UK Dementia Research Institute, Institute of Neurology, University College London, Gower Street, London, WC1E 6BT, United Kingdom., Koutsiouroumpa A; UK Dementia Research Institute, Institute of Neurology, University College London, Gower Street, London, WC1E 6BT, United Kingdom., Muckett P; UK Dementia Research Institute, Institute of Neurology, University College London, Gower Street, London, WC1E 6BT, United Kingdom., Freeman OJ; Neuroscience BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom., Khakh BS; Department of Physiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1751, USA; Department of Neurobiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1751, USA., Hong S; UK Dementia Research Institute, Institute of Neurology, University College London, Gower Street, London, WC1E 6BT, United Kingdom.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Dec 30. Date of Electronic Publication: 2024 Dec 30.

Microglia-synapse engulfment via PtdSer-TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models.

Autor: Rueda-Carrasco J; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Sokolova D; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK.; Neuroscience BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Lee SE; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK.; Department of Physiology and Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea., Childs T; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Jurčáková N; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK.; Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK., Crowley G; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., De Schepper S; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Ge JZ; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Lachica JI; The Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK., Toomey CE; The Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK., Freeman OJ; Neuroscience BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Hardy J; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK., Barnes SJ; UK Dementia Research Institute, Department of Brain Sciences, Imperial College London, London, UK., Lashley T; The Queen Square Brain Bank for Neurological Disorders, UCL Queen Square Institute of Neurology, London, UK.; Department of Neurodegenerative Diseases, UCL Queen Square Institute of Neurology, London, UK., Stevens B; F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA, USA., Chang S; Department of Physiology and Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea., Hong S; UK Dementia Research Institute, Institute of Neurology, University College London, London, UK.

Publikováno v: The EMBO journal [EMBO J] 2023 Oct 04; Vol. 42 (19), pp. e113246. Date of Electronic Publication: 2023 Aug 14.

The UPR and synaptic dysfunction in neurodegeneration.

Autor: Freeman OJ; Department of Clinical Neurosciences, Clifford Allbutt Building, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0AH, UK. Electronic address: ojf28@medschl.cam.ac.uk., Mallucci GR; Department of Clinical Neurosciences, Clifford Allbutt Building, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0AH, UK. Electronic address: gm522@cam.ac.uk.

Publikováno v: Brain research [Brain Res] 2016 Oct 01; Vol. 1648 (Pt B), pp. 530-537. Date of Electronic Publication: 2016 Mar 26.

Metabolic Dysfunction Is Restricted to the Sciatic Nerve in Experimental Diabetic Neuropathy.

Autor: Freeman OJ; Faculty of Life Sciences, The University of Manchester, Manchester, U.K. Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, U.K., Unwin RD; Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, U.K. Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, U.K., Dowsey AW; Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, U.K. Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, U.K., Begley P; Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, U.K. Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, U.K., Ali S; Faculty of Life Sciences, The University of Manchester, Manchester, U.K., Hollywood KA; Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, U.K. Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, U.K., Rustogi N; Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, U.K. Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, U.K., Petersen RS; Faculty of Life Sciences, The University of Manchester, Manchester, U.K., Dunn WB; Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, U.K. Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, U.K., Cooper GJ; Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, U.K. Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical and Human Sciences, The University of Manchester, Manchester, U.K. School of Biological Sciences, The University of Auckland, Auckland, New Zealand Department of Pharmacology, Medical Sciences Division, University of Oxford, Oxford, U.K. natalie.gardiner@manchester.ac.uk garth.cooper@manchester.ac.uk., Gardiner NJ; Faculty of Life Sciences, The University of Manchester, Manchester, U.K. natalie.gardiner@manchester.ac.uk garth.cooper@manchester.ac.uk.

Publikováno v: Diabetes [Diabetes] 2016 Jan; Vol. 65 (1), pp. 228-38. Date of Electronic Publication: 2015 Oct 15.

Low-dimensional sensory feature representation by trigeminal primary afferents.

Autor: Bale MR; Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom., Davies K, Freeman OJ, Ince RA, Petersen RS

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2013 Jul 17; Vol. 33 (29), pp. 12003-12.