Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Oivin M. Guicherit"'
Autor:
Yin Xu, Beatrice I. Zaharian, Hynek Wichterle, Oivin M. Guicherit, Christine L. Gatchalian, Ling Chai, Lee L. Rubin, Charlene Kon, Frank Wang, Juliet A. Williams, Jeffery A. Porter
Publikováno v:
Proceedings of the National Academy of Sciences. 100:4616-4621
The link between basal cell carcinoma (BCC) and aberrant activation of the Hedgehog (Hh) signaling pathway has been well established in humans and in mouse models. Here we report the development of assays, including two novel in vitro BCC models, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11efb08d0fa64089659030ae6baa4aa
https://doi.org/10.1073/pnas.0732813100
https://doi.org/10.1073/pnas.0732813100
Publikováno v:
Molecular Cell. 6(3):723-728
Individual cells translate concentration gradients of extracellular factors into all-or-none threshold responses leading to discrete patterns of gene expression. Signaling cascades account for some but not all such threshold responses, suggesting the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3debcad00ad7ab799fad59ce914f2aab
Publikováno v:
Journal of Biological Chemistry. 271:22647-22656
A muscle-specific isoform of adenylosuccinate synthetase (AdSS1, EC) is one of three enzymes that constitute the purine nucleotide cycle, a muscle-specific metabolic cycle. Previously, we showed that the muscle Adss1 gene was highly expressed in both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8caf354bca6ede8d156610eec78bd9b5
https://doi.org/10.1074/jbc.271.37.22647
https://doi.org/10.1074/jbc.271.37.22647
Publikováno v:
Journal of Biological Chemistry. 269:4488-4496
Adenylosuccinate synthetase (EC 6.3.4.4) catalyzes the initial step in the conversion of IMP to AMP. Two isoforms of this enzyme have been observed in vertebrates. A muscle isozyme is highly abundant in cardiac and skeletal muscle tissue and is thoug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79c8dd146a761a938cbcc17e30b7a3e8
https://doi.org/10.1016/s0021-9258(17)41805-9
https://doi.org/10.1016/s0021-9258(17)41805-9
Publikováno v:
Journal of Biological Chemistry. 268:23728-23733
Recent studies on the tissue distribution and developmental regulation of adenosine deaminase (ADA) activity in mice show that very high ADA levels exist in the murine alimentary tract (tongue, esophagus, forestomach, proximal small intestine) and at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::769271ee26d705080a4d60d347afc2e3
https://doi.org/10.1016/s0021-9258(19)49521-5
https://doi.org/10.1016/s0021-9258(19)49521-5
Autor:
John H. A. Stibbard, Lee L. Rubin, Raffaella Di Lucrezia, Shirley A. Brunton, Stephen Price, Edward Andrew Boyd, L. I. Kruse, Oivin M. Guicherit, Alaric Avery, Colin H. MacKinnon, Danielle Buxton, Yvonne Park
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(15)
A family of biaryl substituted 1,4-diaminocyclohexanamides of 3-chlorobenzothiophene-2-carboxylic acid is reported as picomolar modulators of Hedgehog protein function. SAR for the 1,4-diaminocyclohexane group is shown to be exquisitely sensitive to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fca7d5f894a95789f0f284f494ed03d
https://pubmed.ncbi.nlm.nih.gov/19500978
https://pubmed.ncbi.nlm.nih.gov/19500978
Publikováno v:
Journal of Biological Chemistry. 266:22582-22587
Adenylosuccinate synthetase (EC 6.3.4.4) catalyzes the first step in formation of AMP from IMP. At least two isozymes exist in vertebrate tissue. An acidic form, present in most tissues, has been suggested to be involved in de novo biosynthesis while
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::989e15f88c034f827c38f9f47f954d10
https://doi.org/10.1016/s0021-9258(18)54611-1
https://doi.org/10.1016/s0021-9258(18)54611-1
Autor:
Fabio M.V. Rossi, Bruce T. Blakely, Andrew M. Kringstein, Oivin M. Guicherit, Károly Fátyol, Albert Spicher, Helen M. Blau
Publikováno v:
Nature genetics. 20(4)
Continuous regulation is required to maintain a given cell state or to allow it to change in response to the environment. Studies of the mechanisms underlying such regulation have often been hindered by the inability to control gene expression at wil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dd9c776b91d2428d44b9e58677634f0
https://pubmed.ncbi.nlm.nih.gov/9843215
https://pubmed.ncbi.nlm.nih.gov/9843215
Publikováno v:
Purine and Pyrimidine Metabolism in Man VIII ISBN: 9781461361053
Adenylosuccinate synthetase (AdSS) catalyzes the first of two steps leading to the synthesis of AMP from IMP. Two isoforms of AdSS have been observed in all mammalian species examined (Stayton et al., 1983). One isoform, termed the nonmuscle isozyme,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1953019ea6cb2231661bbcb2ba355e71
https://doi.org/10.1007/978-1-4615-2584-4_122
https://doi.org/10.1007/978-1-4615-2584-4_122
Publikováno v:
Somatic cell and molecular genetics. 20(5)
Adenylosuccinate synthetase (AdSS) functions at the branchpoint of purine nucleotide metabolism leading to the synthesis of AMP. The enzyme is inhibited by a metabolite of alanosine, an aspartic acid analog that is highly cytotoxic for most cells. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dd5f8ecde63e90376a9c4509a466069
https://pubmed.ncbi.nlm.nih.gov/7825060
https://pubmed.ncbi.nlm.nih.gov/7825060