Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Oivin Guichert"'
Autor:
Georgette Castanedo, Shirley A. Brunton, Susan Wong, James C. Marsters, Lesley J. Murray, Laurent Salphati, Karen Kotkow, Cyrus Khojasteh, Kevin Lau, Stanley Mark S, Michael F. T. Koehler, Dina Michael S, Lee L. Rubin, Wei Jia, Hank La, Daniel P. Sutherlin, Leslie Lee, Shumei Wang, Jason Halladay, Changgeng Qian, John H. A. Stibbard, Savita Ubhayaker, Janet L. Gunzner, Kirk Robarge, Stephen E. Gould, Oivin Guichert, Minli Xie, Lalonde Rebecca, Richard Goldsmith, Yong Cui, Derek Marshall
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5576-5581
SAR for a wide variety of heterocyclic replacements for a benzimidazole led to the discovery of functionalized 2-pyridyl amides as novel inhibitors of the hedgehog pathway. The 2-pyridyl amides were optimized for potency, PK, and drug-like properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e862c173e6b7fb83ca5bda975f9f516c
https://doi.org/10.1016/j.bmcl.2009.08.049
https://doi.org/10.1016/j.bmcl.2009.08.049
Autor:
James C. Marsters, Susan Wong, Laurent Salphati, Jason Halladay, Daniel J. Burdick, Gerrit J. P. Dijkgraaf, Stephen E. Gould, Oivin Guichert, Daniel P. Sutherlin, Georgette Castanedo, Frederic J. de Sauvage, Janet L. Gunzner, Elizabeth Blackwood, Emile Plise, Leslie Lee, Shumei Wang, Christine Chang, Kirk Robarge, Cyrus Khojasteh, Lesley J. Murray, David A. Peterson
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(22)
Potent and efficacious inhibitors of the hedgehog pathway for the treatment of cancer have been prepared using the 2-pyridyl biphenyl amide scaffold common to the clinical lead GDC-0449. Analogs with polar groups in the para-position of the aryl amid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e989f535d0e0f689af3c20c7374389a
https://pubmed.ncbi.nlm.nih.gov/20875741
https://pubmed.ncbi.nlm.nih.gov/20875741
Autor:
Janet L. Gunzner, Dina Michael S, Laurent Salphati, Karen Kotkow, James C. Marsters, Richard Goldsmith, Lesley J. Murray, Yong Cui, Hank La, Wei Jia, Jason Halladay, Kirk Robarge, Daniel P. Sutherlin, Lalonde Rebecca, Derek Marshall, Savita Ubhayaker, Shirley A. Brunton, Changgeng Qian, John H. A. Stibbard, Georgette Castanedo, Susan Wong, Leslie Lee, Cyrus Khojasteh, Lee L. Rubin, Shumei Wang, Stanley Mark S, Michael F. T. Koehler, Kevin Lau, Stephen E. Gould, Oivin Guichert, Minli Xie
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:771
Kirk D. Robarge *, Shirley A. Brunton , Georgette M. Castanedo , Yong Cui , Michael S. Dina , Richard Goldsmith , Stephen E. Gould , Oivin Guichert , Janet L. Gunzner , Jason Halladay , Wei Jia , Cyrus Khojasteh , Michael F. T. Koehler , Karen Kotkow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6abc5f52cbbd6cce8c4952ab00ea8953
https://doi.org/10.1016/j.bmcl.2009.11.129
https://doi.org/10.1016/j.bmcl.2009.11.129