Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Oicheng Ng"'
Autor:
Oicheng Ng, Thomas A. Brown, Robert F. Day, Amy Brault, Robert L. Rosati, Bruce Allen Lefker, Pia Perry, Bihong Lu, Thomas A. Owen, Michael P. Zawistoski, Richard Chesworth, Tessa A. Castleberry, Kimberly O. Cameron, Lydia C. Pan, David D. Thompson, Paul DaSilva-Jardine, F.Michael Mangano, Stacy Colella, Donna N. Petersen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2729-2733
Two series of 6-hydroxy and 7-hydroxy tetrahydroisoquinolines were prepared. Evaluating a range of C-1, C-4, and N-substituents led to the discovery of ER alpha and ER beta selective analogs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ab8b698587572775e155590995ad59
https://doi.org/10.1016/j.bmcl.2004.03.077
https://doi.org/10.1016/j.bmcl.2004.03.077
Autor:
Oicheng Ng, John Inthavongsay, Theresa C. Wilson, Bruce Allen Lefker, Anthony Michael Campeta, Ann S. Wright, Hada William Andrew, John R. Hadcock, David A. Tess, Lydia C. Pan, K.L. Chidsey-Frink, F.Michael Mangano, Steven M. Toler, Colin R. Rose, Ewell R. Cook, Li Yu, C.M. Pirie, David F. Nickerson, Shari L. DeNinno, Joseph DiBrino, John A. Ragan, Paul DaSilva-Jardine, Michelle A. Mullins, David D. Thompson, Philip A. Carpino, Michael P. Zawistoski
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:581-590
Novel pyrazolinone-piperidine dipeptide derivatives were synthesized and evaluated as growth hormone secretagogues (GHSs). Two analogues, capromorelin ( 5 , CP-424391-18, hGHS-R1a K i =7 nM, rat pituicyte EC 50 =3 nM) and the des-methyl analogue 5c (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee90ef449e2e33cb480f51243353e6df
https://doi.org/10.1016/s0968-0896(02)00433-9
https://doi.org/10.1016/s0968-0896(02)00433-9
Autor:
John Inthavongsay, Theresa C. Wilson, Li Yu, Colin R. Rose, Hada William Andrew, Oicheng Ng, John R. Hadcock, David D. Thompson, David F. Nickerson, Michelle A. Mullins, Steven M. Toler, F.Michael Mangano, Paul DaSilva-Jardine, Ewell R. Cook, Bruce Allen Lefker, C.M. Pirie, David A. Tess, Lydia C. Pan, Lewis Sharon K, Michael P. Zawistoski, Ann S. Wright, Joseph DiBrino, K.L. Chidsey-Frink, Murray Marianne C, Philip A. Carpino, Shari L. DeNinno, John C. Pettersen, John A. Ragan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:3279-3282
New tert -butyl, picolyl and fluorinated analogues of capromorelin ( 3 ), a short-acting growth hormone secretagogue (GHS), were prepared as part of a program to identify long-acting GHSs that increase 24-h plasma IGF-1 levels. Compounds 4c and 4d (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1be688b588cfdcb84bb787954c1dac
https://doi.org/10.1016/s0960-894x(02)00734-5
https://doi.org/10.1016/s0960-894x(02)00734-5
Autor:
Bihong Lu, C.M. Pirie, David B. MacLean, David D. Thompson, David F. Nickerson, K.L. Chidsey-Frink, Steven M. Toler, Oicheng Ng, John C. Pettersen, Bruce Allen Lefker, John A. Ragan, Paul DaSilva-Jardine, David A. Tess, Lydia C. Pan, Philip A. Carpino, Michelle A. Mullins, David Nettleton
Publikováno v:
Endocrine. 14:121-132
Growth hormone secretagogues (GHSs) represent attractive therapeutic alternatives to recombinant growth hormone (GH), given their ability to amplify pulsatile hormone secretion in a relatively physiologic manner. CP-424,391 (391) is a novel, orally a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c53556949ff7194c40ece7b42e39d1ed
https://doi.org/10.1385/endo:14:1:121
https://doi.org/10.1385/endo:14:1:121
Autor:
Amy Brault, Laura Dianne Gegnas, David Galluzzo, Richard Chesworth, Oicheng Ng, Kimberly O. Cameron, Lisa Heyden, Paul DaSilva-Jardine, Jeanne Tickner, Michael P. Zawistoski, Tessa A. Castleberry, Lydia C. Pan, F.Michael Mangano, Pia Perry, Thomas A. Owen, Matthew David Wessel, Bruce Allen Lefker, Bihong Lu, David D. Thompson, Thomas A. Brown, Hua Zhu Ke, Donna N. Petersen
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(24)
A series of ligands with varying heterocyclic cores and substituents that display a range of selectivity's (up to >100x) for ER-beta over ER-alpha are reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca3e4c593d53eedaf9ea8562a8c4ed8
https://pubmed.ncbi.nlm.nih.gov/16219463
https://pubmed.ncbi.nlm.nih.gov/16219463
Autor:
Philip A, Carpino, Bruce A, Lefker, Steven M, Toler, Lydia C, Pan, John R, Hadcock, Ewell R, Cook, Joseph N, DiBrino, Anthony M, Campeta, Shari L, DeNinno, Kristin L, Chidsey-Frink, William A, Hada, John, Inthavongsay, F Michael, Mangano, Michelle A, Mullins, David F, Nickerson, Oicheng, Ng, Christine M, Pirie, John A, Ragan, Colin R, Rose, David A, Tess, Ann S, Wright, Li, Yu, Michael P, Zawistoski, Paul A, DaSilva-Jardine, Theresa C, Wilson, David D, Thompson
Publikováno v:
Bioorganicmedicinal chemistry. 11(4)
Novel pyrazolinone-piperidine dipeptide derivatives were synthesized and evaluated as growth hormone secretagogues (GHSs). Two analogues, capromorelin (5, CP-424391-18, hGHS-R1a K(i)=7 nM, rat pituicyte EC(50)=3 nM) and the des-methyl analogue 5c (hG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::92b65a6afa8270ad7ecd34dd391b8451
https://pubmed.ncbi.nlm.nih.gov/12538023
https://pubmed.ncbi.nlm.nih.gov/12538023