P121 - Topic: AS07-Singular Entities/Subtypes/AS07e-Chronic myelomonocytic leukemia and overlap syndromes (MDS/MPN): UNDERSTANDING CMML BIOLOGY BY INTEGRATIVE ANALYSIS OF EXOME SEQUENCING, RNA SEQUENCING, AND METHYLOME IN A LARGE PATIENT COHORT

Autor: Kynning, M. Kjellander, Nannya, Y., Todisco, G., Yoshizato, T., Tesi, B., Mortera-Blanco, T., Björklund, A.-C., Brück, O., Ohyashiki, K., Ishikawa, T., Ochi, Y., Haferlach, T., Mustjoki, S., Hellstrom-Lindberg, E., Ogawa, S., Ungerstedt, J.

Publikováno v: In Leukemia Research May 2023 128 Supplement

O11 - POST-AZACITIDINE CLONE SIZE PREDICTS LONG-TERM OUTCOME OF PATIENTS WITH MYELODYSPLASTIC SYNDROMES AND RELATED MYELOID NEOPLASMS

Autor: Nannya, Y., Tobiasson, M., Sato, S., Bernard, E., Ohtake, S., Takeda, J., Creignou, M., Kusakabe, M., Shibata, Y., Nakamura, N., Watanabe, M., Hiramoto, N., Shiozawa, Y., Shiraishi, Y., Tanaka, H., Yoshida, K., Kakicuchi, N., Makishima, H., Nakagawa, M., Usuki, K., Imada, K., Handa, H., Taguchi, M., Kiguchi, T., Ohyashiki, K., Ishikawa, T., Takaori, A., Tsurumi, H., Kasahara, S., Chiba, S., Naoe, T., Miyano, S., Papaemmanuil, E., Miyazaki, Y., Hellstrom-Lindberg, E., Ogawa, S.

Publikováno v: In Leukemia Research May 2023 128 Supplement

Long-term follow-up after R-High CHOP/CHASER/LEED with Auto-PBSCT in untreated mantle cell lymphoma-Final analysis of JCOG0406.

Autor: Ogura M; Department of Hematology, Aichi Sannomaru Clinic, Nagoya, Japan.; Department of Hematology and Oncology, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan., Yamamoto K; Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan., Morishima Y; Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan., Wakabayashi M; JCOG Data Center, National Cancer Center Hospital, Tokyo, Japan., Tobinai K; Department of Hematology, National Cancer Center Hospital, Tokyo, Japan., Ando K; Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan., Uike N; Department of Hematology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan., Kurosawa M; Department of Hematology, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan., Gomyo H; Department of Hematology, Hyogo Cancer Center, Akashi, Japan., Taniwaki M; Department of Hematology, Kyoto Prefectural University of Medicine, Kyoto, Japan., Nosaka K; Department of Hematology, Kumamoto University School of Medicine, Kumamoto, Japan., Tsukamoto N; Department of Hematology, Gunma University Hospital, Maebashi, Japan., Shimoyama T; Department of Medical Oncology, Tokyo Metropolitan Cancer and Infectious Diseases Center, Tokyo, Japan., Fukuhara N; Department of Hematology, Tohoku University Hospital, Sendai, Japan., Yakushijin Y; First Department of Internal Medicine, Ehime University Graduate School of Medicine, Tohon-shi, Japan., Ohnishi K; Department of Hematology, Hamamatsu University School of Medicine, Hamamatsu, Japan., Miyazaki K; Department of Hematology and Oncology, Mie University Graduate School of Medicine, Tsu, Japan., Kameoka Y; Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan., Takayama N; Second Department of Internal Medicine, Kyorin University School of Medicine, Mitaka, Japan., Hanamura I; Division of Hematology, Department of Internal Medicine, Aichi Medical University, Nagakute, Japan., Kobayashi H; Department of Hematology, Saitama Cancer Center Hospital, Saitama, Japan., Usuki K; Department of Hematology, NTT Medical Center Tokyo, Tokyo, Japan., Kobayashi N; Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan., Ohyashiki K; Department of Hematology, Tokyo Medical University, Tokyo, Japan., Utsumi T; Department of Hematology, Shiga General Hospital, Moriyama, Japan., Kumagai K; Department of Hematology, Chiba Cancer Center, Chiba, Japan., Maruyama D; Department of Hematology, National Cancer Center Hospital, Tokyo, Japan., Ohmachi K; Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan., Matsuno Y; Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan., Nakamura S; Department of Pathology and Clinical Laboratories, Nagoya University Hospital, Nagoya, Japan., Hotta T; National Hospital Organization Nagoya Medical Center, Nagoya, Japan., Tsukasaki K; Department of Hematology, National Cancer Center East, Kashiwa, Japan., Nagai H; Department of Hematology, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.

Publikováno v: Cancer science [Cancer Sci] 2023 Aug; Vol. 114 (8), pp. 3461-3465. Date of Electronic Publication: 2023 May 26.

O09 - Topic: AS04-MDS Biology and Pathogenesis/AS04b-Clonal diversity & evolution: MYELOID NEOPLASMS WITH GERMLINE AND SOMATIC DDX41 MUTATIONS

Autor: Makishima, H., Nannya, Y., Momozawa, Y., Gurnari, C., Kulasekararaj, A., Yoshizato, T., Takeda, J., Atsuta, Y., Shiozawa, Y., Iijima-Yamashita, Y., Saiki, R., Yoshida, K., Shiraishi, Y., Nagata, Y., Onizuka, M., Nakagawa, M., Itonaga, H., Kanda, Y., Miyazaki, Y., Sanada, M., Tsurumi, H., Kasahara, S., Kondo-Takaori, A., Ohyashiki, K., Kiguchi, T., Matsuda, F., Jansen, J., Papaemmanuil, E., Creignou, M., Tobiasson, M., Hellström-Lindberg, E., Polprasert, C., Malcovati, L., Cazzola, M., Haferlach, T., Maciejewski, J., Kamatani, Y., Miyano, S., Ogawa, S.

Publikováno v: In Leukemia Research September 2021 108 Supplement

Germ line DDX41 mutations define a unique subtype of myeloid neoplasms.

Autor: Makishima H; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan., Saiki R; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan., Nannya Y; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan., Korotev S; Departments of Medicine and Human Genetics, Section of Hematology/Oncology, The University of Chicago, Chicago, IL., Gurnari C; Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.; Department of Biomedicine and Prevention, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata, Rome, Italy., Takeda J; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan., Momozawa Y; Laboratory for Genotyping Development, Center for Integrative Medical Sciences (IMS), RIKEN, Yokohama, Japan., Best S; King's College Hospital NHS Foundation Trust, and King's College London, London, United Kingdom., Krishnamurthy P; King's College Hospital NHS Foundation Trust, and King's College London, London, United Kingdom., Yoshizato T; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan., Atsuta Y; Japanese Data Center for Hematopoietic Cell Transplantation, Nagakute, Japan., Shiozawa Y; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.; Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan., Iijima-Yamashita Y; Department of Advanced Diagnosis, Clinical Research Center, Nagoya Medical Center, Nagoya, Japan., Yoshida K; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan., Shiraishi Y; National Cancer Center Research Institute, Division of Genome Analysis Platform Development, Tokyo, Japan., Nagata Y; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan., Kakiuchi N; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan., Onizuka M; Department of Hematology and Oncology, Tokai University School of Medicine, Isehara, Japan., Chiba K; National Cancer Center Research Institute, Division of Genome Analysis Platform Development, Tokyo, Japan., Tanaka H; Laboratory of Sequence Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Kon A; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan., Ochi Y; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan., Nakagawa MM; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan., Okuda R; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan., Mori T; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan., Yoda A; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan., Itonaga H; Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan., Miyazaki Y; Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan., Sanada M; Department of Advanced Diagnosis, Clinical Research Center, Nagoya Medical Center, Nagoya, Japan., Ishikawa T; Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan., Chiba S; Department of Hematology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan., Tsurumi H; Department of Hematology, Gifu University, Gifu, Japan., Kasahara S; Department of Hematology, Gifu Municipal Hospital, Gifu, Japan., Müller-Tidow C; Department of Medicine V, University Hospital Heidelberg, Heidelberg, Germany., Takaori-Kondo A; Department of Hematology, Kyoto University, Kyoto, Japan., Ohyashiki K; Department of Hematology, Tokyo Medical University, Tokyo, Japan., Kiguchi T; Chugoku Central Hospital, Fukuyama, Japan., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Jansen JH; Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands., Polprasert C; Department of Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand., Blombery P; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia., Kamatani Y; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Miyano S; National Cancer Center Research Institute, Division of Genome Analysis Platform Development, Tokyo, Japan.; Laboratory of Sequence Analysis, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Medical and Dental, Data Science Center, Tokyo Medical and Dental University, Tokyo, Japan., Malcovati L; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Haferlach T; MLL Munich Leukemia Laboratory, Munich, Germany., Kubo M; Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Cazzola M; Department of Molecular Medicine, University of Pavia, Pavia, Italy., Kulasekararaj AG; King's College Hospital NHS Foundation Trust, and King's College London, London, United Kingdom., Godley LA; Departments of Medicine and Human Genetics, Section of Hematology/Oncology, The University of Chicago, Chicago, IL., Maciejewski JP; Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH., Ogawa S; Department of Pathology and Tumor Biology, Kyoto University, Kyoto, Japan.; Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University, Kyoto, Japan.; Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Publikováno v: Blood [Blood] 2023 Feb 02; Vol. 141 (5), pp. 534-549.