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Efficacy and safety of twice‐daily tramadol hydrochloride bilayer sustained‐release tablets with an immediate release component for postherpetic neuralgia: Results of a Phase III, randomized, double‐blind, placebo‐controlled, treatment‐withdrawal study

Autor: Kawai, Shinichi, Hasegawa, Jun, Ito, Hideki, Fukuuchi, Yasuo, Nakano, Hideshi, Ohtani, Hideaki, Sasaki, Kazutaka, Adachi, Takeshi

Publikováno v: Pain Practice; Mar2023, Vol. 23 Issue 3, p277-289, 13p, 2 Diagrams, 3 Charts, 2 Graphs

Phase III study of bilayer sustained-release tramadol tablets in patients with cancer pain: a double-blind parallel-group, non-inferiority study with immediate-release tramadol capsules as an active comparator.

Autor: Shinkai M; Tokyo Shinagawa Hospital, Tokyo, Japan. shinkai050169@gmail.com., Katsumata N; Nippon Medical School Musashikosugi Hospital, Kanagawa, Japan., Kawai S; Toho University, Tokyo, Japan., Kuyama S; National Hospital Organization Iwakuni Clinical Center, Yamaguchi, Japan., Sasaki O; Miyagi Cancer Center, Miyagi, Japan., Yanagita Y; Gunma Prefectural Cancer Center, Gunma, Japan., Yoshida M; Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan., Uneda S; Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan., Tsuji Y; Tonan Hospital, Hokkaido, Japan., Harada H; Yamaguchi University Hospital, Yamaguchi, Japan., Nishida Y; Keiyukai Sapporo Hospital, Hokkaido, Japan., Sakamoto Y; Osaki Citizen Hospital, Miyagi, Japan., Himeji D; Miyazaki Prefectural Miyazaki Hospital, Miyazaki, Japan., Arioka H; Yokohama Rosai Hospital, Kanagawa, Japan., Sato K; Nagaoka Red Cross Hospital, Niigata, Japan., Katsuki R; National Hospital Organization Ureshino Medical Center, Saga, Japan., Shomura H; Japan Community Health Care Organization Hokkaido Hospital, Hokkaido, Japan., Nakano H; Department of Clinical Development, Nippon Zoki Pharmaceutical Co., Ltd., Osaka, Japan., Ohtani H; Department of Clinical Development, Nippon Zoki Pharmaceutical Co., Ltd., Osaka, Japan., Sasaki K; Department of Clinical Development, Nippon Zoki Pharmaceutical Co., Ltd., Osaka, Japan., Adachi T; Department of Clinical Development, Nippon Zoki Pharmaceutical Co., Ltd., Osaka, Japan.

Publikováno v: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2023 Dec 29; Vol. 32 (1), pp. 69. Date of Electronic Publication: 2023 Dec 29.