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PRELP secreted from mural cells protects the function of blood brain barrier through regulation of endothelial cell-cell integrity.

Autor: Davaapil H; UCL Institute of Ophthalmology, UCL, London, Untited Kingdom., Hopkins J; UCL Institute of Ophthalmology, UCL, London, Untited Kingdom., Bonnin N; UCL Institute of Ophthalmology, UCL, London, Untited Kingdom., Papadaki V; UCL Institute of Ophthalmology, UCL, London, Untited Kingdom., Leung A; UCL Institute of Ophthalmology, UCL, London, Untited Kingdom., Kosuge H; Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Tashima T; Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Nakakido M; Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Sekido R; UCL Institute of Ophthalmology, UCL, London, Untited Kingdom., Tsumoto K; Institute of Medical Science, The University of Tokyo, Tokyo, Japan., Sagoo MS; UCL Institute of Ophthalmology, UCL, London, Untited Kingdom.; NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital, London, Untited Kingdom.; Retinoblastoma Genetic Screening Unit, Barts Health NHS Trust, Royal London Hospital, London, Untited Kingdom., Ohnuma SI; UCL Institute of Ophthalmology, UCL, London, Untited Kingdom.

Publikováno v: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2023 Oct 23; Vol. 11, pp. 1147625. Date of Electronic Publication: 2023 Oct 23 (Print Publication: 2023).

Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy.

Autor: Shinozaki Y; Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan.; GLIA Center, University of Yamanashi, Yamanashi, Japan., Leung A; UCL Institute of Ophthalmology, University College London, London, UK., Namekata K; Visual Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan., Saitoh S; Section of Electron Microscopy, Supportive Center for Brain Research, National Institute for Physiological Sciences (NIPS), Aichi, Japan.; Department of Anatomy II and Cell Biology, Fujita Health University School of Medicine, Aichi, Japan., Nguyen HB; Division of Neurobiology and Bioinformatics, NIPS, Aichi, Japan.; Department of Anatomy, Faculty of Medicine, University of Medicine and Pharmacy (UMP), Ho Chi Minh City, Vietnam., Takeda A; Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan., Danjo Y; Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan., Morizawa YM; Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan., Shigetomi E; Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan.; GLIA Center, University of Yamanashi, Yamanashi, Japan., Sano F; Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan., Yoshioka N; Division of Neurobiology and Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan., Takebayashi H; Division of Neurobiology and Anatomy, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan., Ohno N; Division of Ultrastructural Research, NIPS, Aichi, Japan.; Department of Anatomy, Jichi Medical University, Tochigi, Japan., Segawa T; Center for Life Science Research, University of Yamanashi, Yamanashi, Japan., Miyake K; Department of Health Sciences, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan., Kashiwagi K; Department of Ophthalmology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan., Harada T; Visual Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan., Ohnuma SI; UCL Institute of Ophthalmology, University College London, London, UK., Koizumi S; Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Yamanashi, Japan.; GLIA Center, University of Yamanashi, Yamanashi, Japan.

Publikováno v: Science advances [Sci Adv] 2022 Nov 04; Vol. 8 (44), pp. eabq1081. Date of Electronic Publication: 2022 Nov 04.

Whole-Genome Sequencing of Retinoblastoma Reveals the Diversity of Rearrangements Disrupting RB1 and Uncovers a Treatment-Related Mutational Signature.

Autor: Davies HR; Academic Department of Medical Genetics, University of Cambridge, Addenbrooke's Treatment Centre, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.; MRC Cancer Unit, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0XZ, UK., Broad KD; Institute of Ophthalmology, University College London, London EC1V 9EL, UK., Onadim Z; Retinoblastoma Genetic Screening Unit, The Royal London Hospital, Barts Health NHS Trust, London E1 1FR, UK., Price EA; Retinoblastoma Genetic Screening Unit, The Royal London Hospital, Barts Health NHS Trust, London E1 1FR, UK., Zou X; Academic Department of Medical Genetics, University of Cambridge, Addenbrooke's Treatment Centre, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.; MRC Cancer Unit, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0XZ, UK., Sheriff I; Retinoblastoma Service, Royal London Hospital, Barts Health Trust, London E1 1FR, UK., Karaa EK; Pathology Department, Royal London Hospital, Barts Health NHS Trust, London E1 1FR, UK., Scheimberg I; Pathology Department, Royal London Hospital, Barts Health NHS Trust, London E1 1FR, UK., Reddy MA; Retinoblastoma Service, Royal London Hospital, Barts Health Trust, London E1 1FR, UK.; NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital, Institute of Ophthalmology, University College London, London EC1V 2PD, UK., Sagoo MS; Institute of Ophthalmology, University College London, London EC1V 9EL, UK.; Retinoblastoma Service, Royal London Hospital, Barts Health Trust, London E1 1FR, UK.; NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital, Institute of Ophthalmology, University College London, London EC1V 2PD, UK., Ohnuma SI; Institute of Ophthalmology, University College London, London EC1V 9EL, UK., Nik-Zainal S; Academic Department of Medical Genetics, University of Cambridge, Addenbrooke's Treatment Centre, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.; MRC Cancer Unit, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge CB2 0XZ, UK.

Publikováno v: Cancers [Cancers (Basel)] 2021 Feb 11; Vol. 13 (4). Date of Electronic Publication: 2021 Feb 11.

Two Secreted Proteoglycans, Activators of Urothelial Cell-Cell Adhesion, Negatively Contribute to Bladder Cancer Initiation and Progression.

Autor: Papadaki V; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK.; Institute of Fundamental Biological Research, Biomedical Sciences Research Center 'Alexander Fleming', 16672 Vari, Greece., Asada K; Division of Molecular Modification and Cancer Biology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.; Cancer Translational Research Team, RIKEN Center for Advanced Intelligence Project, 1-4-1 Nihonbashi, Chuo-ku, Tokyo 103-0027, Japan., Watson JK; Department of Oncology, The Hutchison/MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.; Stem Cell Technologies, Building 7100, Cambridge Research Park, Beach Drive, Waterbeach, Cambridge CB25 9TL, UK., Tamura T; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK.; Integrated Biology, Research Division Axcelead Drug Discovery Partners, Inc. 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-0012, Japan., Leung A; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK., Hopkins J; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK., Dellett M; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK.; NI Centre for Stratified Medicine, C-TRIC, Altnagelvin Hospital Campus, Glenshane Road, Derry/Londonderry, Northern Ireland BT47 6SB, UK., Sasai N; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK.; Developmental Biomedical Science, Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5, Takayama-cho, Ikoma 630-0192, Japan., Davaapil H; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK.; Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Puddicombe Way, Cambridge Biomedical Campus, Cambridge CB2 0AW, UK., Nik-Zainal S; MRC Cancer Unit University of Cambridge Hutchison/MRC Research Centre Box 197, Cambridge Biomedical Campus, Cambridge CB2 0XZ, UK.; Academic Laboratory of Medical Genetics. Box 238, Lv 6 Addenbrooke's Treatment Centre, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK., Longbottom R; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK.; Critical care, University College London Hospital, 3rd floor, 235 Euston Road, London NW1 2PG, UK., Nakakido M; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK.; Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan., Torii R; Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK., Veerakumarasivam A; Department of Oncology, The Hutchison/MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK.; Department of Biological Sciences, School of Science and Technology, Sunway University, Bandar Sunway, Selangor Darul Ehsan 47500, Malaysia., Kaneko S; Division of Molecular Modification and Cancer Biology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan., Sagoo MS; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK.; Retinoblastoma Service, Royal London Hospital, Whitechapel Road, London E1 1BB, UK.; Ocular Oncology Service, Moorfields Eye Hospital, City Road, London EC1V 2PD, UK.; National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, City Road, London EC1V 2PD, UK., Murphy G; Department of Oncology, The Hutchison/MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK., Mitani A; Department of Respiratory Medicine, The University of Tokyo Hospital, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan., Tsumoto K; Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan., Kelly JD; Department of Oncology, The Hutchison/MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK.; Division of Surgery and Interventional Science, University College London, 74 Huntley Street, London WC1E 6AU, UK., Hamamoto R; Division of Molecular Modification and Cancer Biology, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.; Cancer Translational Research Team, RIKEN Center for Advanced Intelligence Project, 1-4-1 Nihonbashi, Chuo-ku, Tokyo 103-0027, Japan.; Department of Oncology, The Hutchison/MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK.; Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan., Ohnuma SI; UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK.; Department of Oncology, The Hutchison/MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 2XZ, UK.

Publikováno v: Cancers [Cancers (Basel)] 2020 Nov 13; Vol. 12 (11). Date of Electronic Publication: 2020 Nov 13.