Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ohnmar Khanal"'
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101112- (2023)
Recombinant adeno-associated viral vector (rAAV) mediated gene therapy is gaining traction in treating genetic disorders. Current rAAV production systems yield a mixture of capsids largely devoid of the transgene (empty capsid) compared with the desi
Externí odkaz:
https://doaj.org/article/19361272f35442399cfc9c903b0f84c6
Autor:
Ohnmar Khanal, Abraham M. Lenhoff
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Today’s biologics manufacturing practices incur high costs to the drug makers, which can contribute to high prices for patients. Timely investment in the development and implementation of continuous biomanufacturing can increase the production of c
Externí odkaz:
https://doaj.org/article/962a2ec879204ce08bc566e00aeb85b2
Publikováno v:
Biotechnology and Bioengineering. 118:164-174
An efficient and consistent method of monoclonal antibody (mAb) purification can improve process productivity and product consistency. Although protein A chromatography removes most host-cell proteins (HCPs), mAb aggregates and the remaining HCPs are
Autor:
Ohnmar, Khanal
Publikováno v:
Current Opinion in Biotechnology. 78:102796
Chromatography is a widely used separation method that is inherently a batch operation. However, the demand for higher productivity and lower cost and labor has prompted industries such as the petrochemical and food industries to transition from batc
Autor:
Xuankuo Xu, Nripen Singh, Zheng Jian Li, Steven J. Traylor, Ohnmar Khanal, Abraham M. Lenhoff, Sanchayita Ghose, Chao Huang
Publikováno v:
Journal of Membrane Science. :464-471
Depth filtration is a commonly-used bioprocessing unit operation for harvest clarification that reduces the levels of process- and product-related impurities such as cell debris, host-cell proteins, nucleic acids and protein aggregates. Since depth f
Autor:
Abraham M. Lenhoff, Ohnmar Khanal
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Today’s biologics manufacturing practices incur high costs to the drug makers, which can contribute to high prices for patients. Timely investment in the development and implementation of continuous biomanufacturing can increase the production of c
Publikováno v:
Proc Natl Acad Sci U S A
Protein mobility at solid-liquid interfaces can affect the performance of applications such as bioseparations and biosensors by facilitating reorganization of adsorbed protein, accelerating molecular recognition, and informing the fundamentals of ads
Publikováno v:
Journal of chromatography. A. 1586
Native forms of therapeutic monoclonal antibodies (mAbs) coexist with various acidic and basic charge variants throughout process development and into drug product formulation. During downstream purification, a product's charge variant composition is
Autor:
Steven J. Traylor, Zheng Jian Li, Xuankuo Xu, Ohnmar Khanal, Sanchayita Ghose, Nripen Singh, Abraham M. Lenhoff
Publikováno v:
Biotechnology and bioengineering. 115(8)
Depth filtration is widely used in downstream bioprocessing to remove particulate contaminants via depth straining and is therefore applied to harvest clarification and other processing steps. However, depth filtration also removes proteins via adsor