Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Ohman Kwon"'
Autor:
Ohman Kwon, Hana Lee, Jaeeun Jung, Ye Seul Son, Sojeong Jeon, Won Dong Yoo, Naeun Son, Kwang Bo Jung, Eunho Choi, In-Chul Lee, Hyung-Jun Kwon, Chuna Kim, Mi-Ok Lee, Hyun-Soo Cho, Dae Soo Kim, Mi-Young Son
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Three-dimensional human intestinal organoids (hIO) are widely used as a platform for biological and biomedical research. However, reproducibility and challenges for large-scale expansion limit their applicability. Here, we establish a human
Externí odkaz:
https://doaj.org/article/6f5d70098bfd4eaabe1920746c0323fc
Autor:
Hana Lee, Kwang Bo Jung, Ohman Kwon, Ye Seul Son, Eunho Choi, Won Dong Yu, Naeun Son, Jun Hyoung Jeon, Hana Jo, Haneol Yang, Yeong Rak Son, Chan-Seok Yun, Hyun-Soo Cho, Sang Kyu Kim, Dae-Soo Kim, Doo-Sang Park, Mi-Young Son
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
Little is known about the modulatory capacity of the microbiota in early intestinal development. We examined various intestinal models that respond to gut microbial metabolites based on human pluripotent stem cell-derived human intestinal organoids (
Externí odkaz:
https://doaj.org/article/bcedc8c3adae41f9bf2188ec7de1d48b
Next-Generation Intestinal Toxicity Model of Human Embryonic Stem Cell-Derived Enterocyte-Like Cells
Autor:
Bokyeong Ryu, Mi-Young Son, Kwang Bo Jung, Ukjin Kim, Jin Kim, Ohman Kwon, Ye Seul Son, Cho-Rok Jung, Jae-Hak Park, C-Yoon Kim
Publikováno v:
Frontiers in Veterinary Science, Vol 8 (2021)
The gastrointestinal tract is the most common exposure route of xenobiotics, and intestinal toxicity can result in systemic toxicity in most cases. It is important to develop intestinal toxicity assays mimicking the human system; thus, stem cells are
Externí odkaz:
https://doaj.org/article/2203e98e98fd415eac74a9e467ee6a44
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The morphology and structure of the intestinal epithelium are rearranged dynamically during development, tissue regeneration, and disease progression. The most important characteristic of intestinal epithelial morphogenesis is the repetitive compartm
Externí odkaz:
https://doaj.org/article/620ccb4f5c3a4c1eb715288514afa23d
Autor:
Kwang Bo Jung, Hana Lee, Ye Seul Son, Mi-Ok Lee, Young-Dae Kim, Soo Jin Oh, Ohman Kwon, Sunwha Cho, Hyun-Soo Cho, Dae-Soo Kim, Jung-Hwa Oh, Matthias Zilbauer, Jeong-Ki Min, Cho-Rok Jung, Janghwan Kim, Mi-Young Son
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Human pluripotent stem cell-derived intestinal organoids (hIOs) are a useful model with which to study intestinal development and disease, but they require in vivo maturation to resemble adult tissue. Here, the authors show that T lymphocyte-derived
Externí odkaz:
https://doaj.org/article/a475745ef0d7496ba465e8488bf0de6b
Autor:
Kwang Bo Jung, Ohman Kwon, Mi-Ok Lee, Hana Lee, Ye Seul Son, Omer Habib, Jung-Hwa Oh, Hyun-Soo Cho, Cho-Rok Jung, Janghwan Kim, Mi-Young Son
Publikováno v:
Journal of Clinical Medicine, Vol 8, Iss 7, p 976 (2019)
Human intestinal organoids (hIOs), which resemble the human intestine structurally and physiologically, have emerged as a new modality for the study of the molecular and cellular biology of the intestine in vitro. We recently developed an in vitro ma
Externí odkaz:
https://doaj.org/article/bba33a4d7fac4edda70f67f16b2510aa
Publikováno v:
International Journal of Stem Cells. 15:104-111
Many of early findings regarding intestinal stem cells (ISCs) and their niche in the human intestine have relied on colorectal cancer cell lines and labor-intensive and time-consuming mouse models. However, these models cannot accurately recapitulate
Autor:
Jaehwan Ahn, Kwang Bo Jung, Ohman Kwon, Jun-Ho Ahn, Jung-Hwa Oh, Seokjoo Yoon, Hyoung-Yun Han, Mi-Sun Choi, Mi-Young Son, Cho-Rok Jung
Publikováno v:
Analytical Chemistry. 93:8826-8834
Human pluripotent stem cell (hPSC)-derived intestinal organoids (HIOs) hold unprecedented promise for basic biology and translational applications. However, developing a quantitative method to evaluate the epithelial cell membrane integrity of HIOs a
Autor:
Mi-Ok Lee, Cho Rok Jung, Janghwan Kim, Young-Jun Park, Tae Young Ryu, Ohman Kwon, Choong-Min Ryu, Areum Baek, Dae-Soo Kim, Kunhyang Park, Hyun-Soo Cho, Ye Seul Son, Kwangho Kim, Tae Su Han, Kwang Bo Jung, Hana Lee, Jea Woon Ryu, Mi Young Son
Publikováno v:
Theranostics
Several phase 1/2 clinical trials showed that low-dose interleukin-2 (IL-2) treatment is a safe and effective strategy for the treatment of chronic graft-versus-host disease, hepatitis C virus-induced vasculitis, and type 1 diabetes. Ulcerative colit
Autor:
Jeong Ki Min, Ohman Kwon, Tae Young Ryu, Kwangkho Kim, Janghwan Kim, Mi Young Son, Dae-Soo Kim, Hyun-Soo Cho, Cho Rok Jung
Publikováno v:
Molecular Medicine Reports
Short‑chain fatty acids (SCFAs; butyrate, propionate and acetate) are metabolites derived from the gut microbiota via dietary fiber fermentation. In colon cancer, treatment with SCFAs, mainly butyrate and propionate, suppresses cell proliferation,