Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Ohannes K. Melemedjian"'
Publikováno v:
Frontiers in Pain Research, Vol 5 (2024)
IntroductionChemotherapy-induced peripheral neuropathy (CIPN) is a debilitating side effect of cancer treatment that significantly impacts patients' quality of life. This study investigated the effects of targeting metabolic pathways on bortezomib-in
Externí odkaz:
https://doaj.org/article/6707336280f14c9281bfb41ab2bf9e6a
Autor:
Jin Y. Ro, Youping Zhang, Jamila Asgar, Huizhong Shou, Man-Kyo Chung, Ohannes K. Melemedjian, Joyce T. Da Silva, Shou Chen
Publikováno v:
Frontiers in Pain Research, Vol 5 (2024)
This study investigates the impact of combining psychophysical stress, induced by forced swim (FSS), with masseter inflammation on reactive oxygen species (ROS) production in trigeminal ganglia (TG), TRPA1 upregulation in TG, and mechanical hyperalge
Externí odkaz:
https://doaj.org/article/5468e8ebf2fe4d8b84d6630ecb6715c6
Autor:
Sarah M Wilson, Aubin eMoutal, Ohannes K Melemedjian, Yuying eWang, Weina eJu, Liberty eFrancois-Moutal, May eKhanna, Rajesh eKhanna
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 8 (2014)
Activity-dependent neurite outgrowth is a highly complex, regulated process with important implications for neuronal circuit remodeling in development as well as in seizure-induced sprouting in epilepsy. Recent work has linked outgrowth to collapsin
Externí odkaz:
https://doaj.org/article/2cd4bd48660342418d686696ad2bbecb
Autor:
Ohannes K. Melemedjian, Taylor Ludman
Publikováno v:
Molecular pain. 15
Chemotherapy-induced painful peripheral neuropathy (CIPN) is the most common toxicity associated with widely used chemotherapeutics. CIPN is the major cause of dose reduction or discontinuation of otherwise life-saving treatment. Unfortunately, CIPN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ccb53bc52c402164a9c00680cc4f08a
https://pubmed.ncbi.nlm.nih.gov/30810076
https://pubmed.ncbi.nlm.nih.gov/30810076
Autor:
Taylor Ludman, Ohannes K. Melemedjian
Publikováno v:
Molecular Pain
Chemotherapy-induced painful peripheral neuropathy is a significant clinical problem that is associated with widely used chemotherapeutics. Unfortunately, the molecular mechanisms by which chemotherapy-induced painful peripheral neuropathy develops h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fe9a97e97dda73aad2e3e76682d1a8
https://doi.org/10.1177/1744806919850043
https://doi.org/10.1177/1744806919850043
Publikováno v:
Brain Res Bull
Activation of opioid and cannabinoid receptors expressed in nociceptors induces effective antihyperalgesia. In this study, we examined whether combinations of opioid and cannabinoid receptor agonists directed at the injured site would enhance therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc133c2d5db9d2af20336d92007172c
https://europepmc.org/articles/PMC7909681/
https://europepmc.org/articles/PMC7909681/
Autor:
Frank Porreca, Alec Okun, Ohannes K. Melemedjian, Theodore J. Price, Irina Y. Maskaykina, Gregory Dussor, Edward K. Mandell, Chaoling Qu, Tamara King, Edita Navratilova, Sourav Ghosh
Publikováno v:
Pain. 153:1263-1273
Injuries can induce adaptations in pain processing that result in amplification of signaling. One mechanism may be analogous to long-term potentiation and involve the atypical protein kinase C, PKMζ. The possible contribution of PKMζ-dependent and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4dd937163746cebb6d42cd84c815c13
https://doi.org/10.1016/j.pain.2012.03.006
https://doi.org/10.1016/j.pain.2012.03.006
Publikováno v:
Experimental Neurology. 233:740-744
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce7bae35d6896e696596d0cfaf60efb4
https://doi.org/10.1016/j.expneurol.2011.11.016
https://doi.org/10.1016/j.expneurol.2011.11.016
Autor:
Adia Shy, Frank Porreca, Theodore J. Price, Marina N. Asiedu, Ohannes K. Melemedjian, Dipti V. Tillu, Raul Sanoja, Bryce Bodell, Sourav Ghosh
Publikováno v:
The Journal of Neuroscience. 31:6646-6653
Sensitization of the pain pathway is believed to promote clinical pain disorders. We hypothesized that the persistence of a sensitized state in the spinal dorsal horn might depend on the activity of protein kinase M ζ (PKMζ), an essential mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408b1cd2de7b70deeb7d82a8783e1d47
https://doi.org/10.1523/jneurosci.6286-10.2011
https://doi.org/10.1523/jneurosci.6286-10.2011
Autor:
Joseph R. Ghilardi, Monica B Herrera, Marina Vardanyan, Patrick W. Mantyh, Juan Miguel Jimenez-Andrade, Ohannes K. Melemedjian
Publikováno v:
Molecular Pain, Vol 4, Iss 1, p 10 (2008)
Molecular Pain
Molecular Pain
Although a variety of industrial chemicals, as well as several chemotherapeutic agents used to treat cancer or HIV, preferentially induce a peripheral sensory neuropathy what remains unclear is why these agents induce a sensory vs. a motor or mixed n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06192ef0ecc6283ef9fd003e42ec7b3
https://doi.org/10.1186/1744-8069-4-10
https://doi.org/10.1186/1744-8069-4-10