Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

Autor: Lü Y; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.; Department of Biology, Suffolk University, Boston, MA, 02108, USA., Cho T; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada., Mukherjee S; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Suarez CF; Instituto de Investigaciones Biotecnológicas (IIBiO-CONICET), Universidad Nacional de San Martín, Buenos Aires, Argentina., Gonzalez-Foutel NS; Instituto de Investigaciones Biotecnológicas (IIBiO-CONICET), Universidad Nacional de San Martín, Buenos Aires, Argentina., Malik A; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada., Martinez S; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada., Dervovic D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada., Oh RH; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada., Langille E; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada., Al-Zahrani KN; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada., Hoeg L; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada., Lin ZY; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada., Tsai R; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada., Mbamalu G; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada., Rotter V; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Ashton-Prolla P; Departamento de Genética, Universidade Federal do Rio Grande do Sul and Serviço de Genetica Médica HCPA, Porto Alegre, Brasil., Moffat J; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, M5S3G9, Canada.; Genetics and Genome Biology Program, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada., Chemes LB; Instituto de Investigaciones Biotecnológicas (IIBiO-CONICET), Universidad Nacional de San Martín, Buenos Aires, Argentina., Gingras AC; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada., Oren M; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Durocher D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada., Schramek D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada. schramek@lunenfeld.ca.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. schramek@lunenfeld.ca.

Publikováno v: Molecular systems biology [Mol Syst Biol] 2024 Jun; Vol. 20 (6), pp. 719-740. Date of Electronic Publication: 2024 Apr 05.

Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer.

Autor: Langille E; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Al-Zahrani KN; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Ma Z; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California., Liang M; Hospital for Sick Children, Toronto, Ontario, Canada., Uuskula-Reimand L; Hospital for Sick Children, Toronto, Ontario, Canada., Espin R; Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Oncobell, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain., Teng K; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Malik A; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Bergholtz H; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway., Ghamrasni SE; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Afiuni-Zadeh S; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Tsai R; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Alvi S; Hospital for Sick Children, Toronto, Ontario, Canada., Elia A; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Lü Y; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Oh RH; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Kozma KJ; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Hospital for Sick Children, Toronto, Ontario, Canada., Trcka D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Narimatsu M; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Liu JC; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Nguyen T; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Barutcu S; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Loganathan SK; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Bremner R; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Bader GD; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Egan SE; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Hospital for Sick Children, Toronto, Ontario, Canada., Cescon DW; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Sørlie T; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Wrana JL; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Jackson HW; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Wilson MD; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Hospital for Sick Children, Toronto, Ontario, Canada., Witkiewicz AK; Center for Personalized Medicine, Roswell Park Cancer Institute, Buffalo, New York., Knudsen ES; Center for Personalized Medicine, Roswell Park Cancer Institute, Buffalo, New York., Pujana MA; Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Oncobell, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain., Wahl GM; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California., Schramek D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

Publikováno v: Cancer discovery [Cancer Discov] 2022 Dec 02; Vol. 12 (12), pp. 2930-2953.

Suppression of circadian secretion of glucagon-like peptide-1 by the saturated fatty acid, palmitate.

Autor: Martchenko A; Department of Physiology, University of Toronto, Toronto, ON, Canada., Oh RH; Department of Physiology, University of Toronto, Toronto, ON, Canada., Wheeler SE; Department of Physiology, University of Toronto, Toronto, ON, Canada., Gurges P; Department of Physiology, University of Toronto, Toronto, ON, Canada., Chalmers JA; Department of Physiology, University of Toronto, Toronto, ON, Canada., Brubaker PL; Department of Physiology, University of Toronto, Toronto, ON, Canada.; Department of Medicine, University of Toronto, Toronto, ON, Canada.

Publikováno v: Acta physiologica (Oxford, England) [Acta Physiol (Oxf)] 2018 Apr; Vol. 222 (4), pp. e13007. Date of Electronic Publication: 2017 Dec 18.