Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancer.

Autor: Joanito I; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Wirapati P; Bioinformatics Core Facility, Swiss Institute of Bioinformatics, Lausanne, Switzerland., Zhao N; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Nawaz Z; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Yeo G; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Lee F; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; National Cancer Centre, Singapore, Singapore., Eng CLP; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; National Cancer Centre, Singapore, Singapore., Macalinao DC; National Cancer Centre, Singapore, Singapore., Kahraman M; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Srinivasan H; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; National Cancer Centre, Singapore, Singapore., Lakshmanan V; National Cancer Centre, Singapore, Singapore., Verbandt S; Molecular Digestive Oncology, Department of Oncology, Katholieke Universiteit Leuven, Leuven, Belgium., Tsantoulis P; Hôpitaux Universitaires de Genève, Geneva, Switzerland.; University of Geneva, Geneva, Switzerland., Gunn N; National Cancer Centre, Singapore, Singapore., Venkatesh PN; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Poh ZW; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.; Duke-National University of Singapore Medical School, Singapore, Singapore., Nahar R; MSD International GmbH (Singapore Branch), Singapore, Singapore., Oh HLJ; MSD International GmbH (Singapore Branch), Singapore, Singapore., Loo JM; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Chia S; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Cheow LF; National University of Singapore, Singapore, Singapore., Cheruba E; National University of Singapore, Singapore, Singapore., Wong MT; MSD International GmbH (Singapore Branch), Singapore, Singapore., Kua L; National Cancer Centre, Singapore, Singapore., Chua C; National Cancer Centre, Singapore, Singapore., Nguyen A; NantOmics, Rockville, MD, USA., Golovan J; NantOmics, Rockville, MD, USA., Gan A; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Lim WJ; National Cancer Centre, Singapore, Singapore., Guo YA; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Yap CK; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Tay B; National Cancer Centre, Singapore, Singapore., Hong Y; Samsung Genome Institute, Samsung Medical Center, Seoul, Korea., Chong DQ; National Cancer Centre, Singapore, Singapore.; Duke-National University of Singapore Medical School, Singapore, Singapore., Chok AY; Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore., Park WY; Samsung Genome Institute, Samsung Medical Center, Seoul, Korea., Han S; National Cancer Centre, Singapore, Singapore., Chang MH; Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore., Seow-En I; Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore., Fu C; Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore., Mathew R; Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore., Toh EL; Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore.; EL Toh Colorectal & Minimally Invasive Surgery, Singapore, Singapore., Hong LZ; MSD International GmbH (Singapore Branch), Singapore, Singapore., Skanderup AJ; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., DasGupta R; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Ong CJ; Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, Singapore, Singapore.; Department of Sarcoma, Peritoneal and Rare Tumours (SPRinT), Division of Surgery and Surgical Oncology, Singapore General Hospital, Singapore, Singapore.; Laboratory of Applied Human Genetics, Division of Medical Sciences, National Cancer Centre Singapore, Singapore, Singapore.; SingHealth Duke-NUS Oncology Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore.; SingHealth Duke-NUS Surgery Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore.; Institute of Molecular and Cell Biology, A*STAR Research Entities, Singapore, Singapore., Lim KH; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore., Tan EKW; Department of Colorectal Surgery, Singapore General Hospital, Singapore, Singapore., Koo SL; National Cancer Centre, Singapore, Singapore., Leow WQ; Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore., Tejpar S; Molecular Digestive Oncology, Department of Oncology, Katholieke Universiteit Leuven, Leuven, Belgium. sabine.tejpar@uzleuven.be., Prabhakar S; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. prabhakars@gis.a-star.edu.sg., Tan IB; Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. iain.tan.b.h@singhealth.com.sg.; National Cancer Centre, Singapore, Singapore. iain.tan.b.h@singhealth.com.sg.; Duke-National University of Singapore Medical School, Singapore, Singapore. iain.tan.b.h@singhealth.com.sg.

Publikováno v: Nature genetics [Nat Genet] 2022 Jul; Vol. 54 (7), pp. 963-975. Date of Electronic Publication: 2022 Jun 30.

Imaging PD-L1 Expression with ImmunoPET.

Autor: Truillet C; Department of Radiology and Biomedical Imaging, ‡Department of Medicine, §Helen Diller Family Comprehensive Cancer Center, ∥Department of Pharmaceutical Chemistry, and ⊥Department of Radiation Oncology, University of California, San Francisco , 505 Parnassus Avenue, San Francisco, California 94143, United States.; Imagerie Moleculaire in Vivo, INSERM, CEA, Université Paris Sud, CNRS, Universite Paris Saclay, CEA-Service Hospitalier Frederic Joliot , Orsay 94100, France., Oh HLJ; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR) , 8A Biomedical Grove Immunos No. 03-06, Biopolis 138648, Singapore., Yeo SP; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR) , 8A Biomedical Grove Immunos No. 03-06, Biopolis 138648, Singapore., Lee CY; Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR) , 8A Biomedical Grove Immunos No. 03-06, Biopolis 138648, Singapore., Huynh LT; Department of Radiology and Biomedical Imaging, ‡Department of Medicine, §Helen Diller Family Comprehensive Cancer Center, ∥Department of Pharmaceutical Chemistry, and ⊥Department of Radiation Oncology, University of California, San Francisco , 505 Parnassus Avenue, San Francisco, California 94143, United States., Wei J; Department of Radiology and Biomedical Imaging, ‡Department of Medicine, §Helen Diller Family Comprehensive Cancer Center, ∥Department of Pharmaceutical Chemistry, and ⊥Department of Radiation Oncology, University of California, San Francisco , 505 Parnassus Avenue, San Francisco, California 94143, United States., Parker MFL; Department of Radiology and Biomedical Imaging, ‡Department of Medicine, §Helen Diller Family Comprehensive Cancer Center, ∥Department of Pharmaceutical Chemistry, and ⊥Department of Radiation Oncology, University of California, San Francisco , 505 Parnassus Avenue, San Francisco, California 94143, United States., Blakely C, Sevillano N, Wang YH; Department of Radiology and Biomedical Imaging, ‡Department of Medicine, §Helen Diller Family Comprehensive Cancer Center, ∥Department of Pharmaceutical Chemistry, and ⊥Department of Radiation Oncology, University of California, San Francisco , 505 Parnassus Avenue, San Francisco, California 94143, United States., Shen YS; Department of Radiology and Biomedical Imaging, ‡Department of Medicine, §Helen Diller Family Comprehensive Cancer Center, ∥Department of Pharmaceutical Chemistry, and ⊥Department of Radiation Oncology, University of California, San Francisco , 505 Parnassus Avenue, San Francisco, California 94143, United States., Olivas V, Jami KM; Department of Radiology and Biomedical Imaging, ‡Department of Medicine, §Helen Diller Family Comprehensive Cancer Center, ∥Department of Pharmaceutical Chemistry, and ⊥Department of Radiation Oncology, University of California, San Francisco , 505 Parnassus Avenue, San Francisco, California 94143, United States., Moroz A; Skolkovo Institute of Science and Technology, Skolkovo Innovation Center , 3 Nobel Street, Moscow 143026, Russia., Jego B; Imagerie Moleculaire in Vivo, INSERM, CEA, Université Paris Sud, CNRS, Universite Paris Saclay, CEA-Service Hospitalier Frederic Joliot , Orsay 94100, France., Jaumain E; Imagerie Moleculaire in Vivo, INSERM, CEA, Université Paris Sud, CNRS, Universite Paris Saclay, CEA-Service Hospitalier Frederic Joliot , Orsay 94100, France., Fong L, Craik CS, Chang AJ, Bivona TG, Wang CI; Imagerie Moleculaire in Vivo, INSERM, CEA, Université Paris Sud, CNRS, Universite Paris Saclay, CEA-Service Hospitalier Frederic Joliot , Orsay 94100, France., Evans MJ; Department of Radiology and Biomedical Imaging, ‡Department of Medicine, §Helen Diller Family Comprehensive Cancer Center, ∥Department of Pharmaceutical Chemistry, and ⊥Department of Radiation Oncology, University of California, San Francisco , 505 Parnassus Avenue, San Francisco, California 94143, United States.

Publikováno v: Bioconjugate chemistry [Bioconjug Chem] 2018 Jan 17; Vol. 29 (1), pp. 96-103. Date of Electronic Publication: 2017 Nov 15.