Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Oguz, Ersoy"'
Publikováno v:
Tetrahedron. 62:3439-3445
A library of 1,3-disubstituted indoles has been prepared via an iterative Mannich reaction sequence. The first Mannich reaction with secondary amines and formaldehyde preferentially yields 3-aminomethyl indoles, while the second Mannich reaction intr
Autor:
Andreas Axén, Hans O Andersson, Ulf Tedebark, Oguz Ersoy, Enrique Carredano, Herbert Baumann, Maria Westerfors, Devapriya Choudhury, Sara Öhrman, Yasuro Shinohara
Publikováno v:
Journal of Molecular Recognition. 16:396-405
A ligand useful for affinity capture of porcine pancreatic α-amylase was found by virtual screening of the commercially available compound data base MDL® Available Chemicals Directory. Hits from the virtual screening were investigated for binding b
Autor:
Oguz Ersoy, Devapriya Choudhury, Andreas Axén, Enrique Carredano, Ulf Tedebark, Yasuro Shinohara, Sara Öhrman, Herbert Baumann
Publikováno v:
Protein Science. 12:784-793
The structure-based design, synthesis, and screening of a glucuronic acid scaffold library of affinity ligands directed toward the catalytic cleft on porcine pancreas alpha-amylase are presented. The design was based on the simulated docking to the e
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4738-4740
A class of inhibitors of mitogen activated protein kinase-activated kinase 2 (MK2) was discovered via high-throughput screening. This compound class demonstrates activity against the enzyme with sub-microM IC(50) values, and suppresses LPS-induced TN
Publikováno v:
Bioorganic & Medicinal Chemistry. 7:279-286
Design principles and syntheses of three haptens that were recently reported to generate amide bond cleaving catalytic antibodies are described. The hapten designs sought to induce acidic and/or basic residues in antibody binding sites via charge com
Publikováno v:
Journal of the American Chemical Society. 116:487-494
Three structurally related haptens 1-3 were designed and synthesized with the goal of generating antibodies for the hydrolysis of ester 4a and amide 4b. These haptens contain a 1,2-amino alcohol functionality which replaces the ester Jamide moiety of
Publikováno v:
ChemInform. 25
Three structurally related haptens 1-3 were designed and synthesized with the goal of generating antibodies for the hydrolysis of ester 4a and amide 4b. These haptens contain a 1,2-amino alcohol functionality which replaces the ester Jamide moiety of
Autor:
Oguz Ersoy, Enrique Carredano, Andreas Axén, Herbert Baumann, Anna Grönberg, Jinyu Zou, Nils Norrman, Gunnar Glad, Elles Steensma
Antibodies of type IgG may be divided into two classes, called lambda or kappa, depending on the type of light chain. We have identified a conserved pocket between the two domains CH1 and CL of human IgG kappa-Fab, which is not present in the lambda
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c25b160af2f0bd92c62580a7657c4c
https://europepmc.org/articles/PMC2279986/
https://europepmc.org/articles/PMC2279986/
Autor:
Maria, Westerfors, Ulf, Tedebark, Hans O, Andersson, Sara, Ohrman, Devapriya, Choudhury, Oguz, Ersoy, Yasuro, Shinohara, Andreas, Axén, Enrique, Carredano, Herbert, Baumann
Publikováno v:
Journal of molecular recognition : JMR. 16(6)
A ligand useful for affinity capture of porcine pancreatic alpha-amylase was found by virtual screening of the commercially available compound data base MDL Available Chemicals Directory. Hits from the virtual screening were investigated for binding
Autor:
Astrid Samuelsson, Oguz Ersoy, Fayezeh Yari, Jorma Hinkula, Mats A. A. Persson, Erling Norrby
Publikováno v:
European journal of immunology. 26(12)
Human antibodies against HIV-1 have been sought to study neutralization events on the molecular level, and for possible use in passive immune intervention. The development of phage display techniques has opened the possibility of rapidly generating h